Publications by authors named "Helene Benedetti"

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An Atypical Mechanism of SUMOylation of Neurofibromin SecPH Domain Provides New Insights into SUMOylation Site Selection.
Mohammed Bergoug, Christine Mosrin, Amandine Serrano, Fabienne Godin, Michel Doudeau

J Mol Biol· November 2024

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Tetrahydropyridine LIMK inhibitors: Structure activity studies and biological characterization.
Anthony Champiré, Rayan Berabez, Abdennour Braka, Aurélie Cosson, Justine Corret

Eur J Med Chem· May 2024

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LIM Kinases: From Molecular to Pathological Features.
Hélène Bénédetti, Béatrice Vallée

Cells· June 2023

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LIM Kinases, LIMK1 and LIMK2, Are Crucial Node Actors of the Cell Fate: Molecular to Pathological Features.
Elodie Villalonga, Christine Mosrin, Thierry Normand, Caroline Girardin, Amandine Serrano

Cells· March 2023

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Confocal imaging of biomarkers at a single-cell resolution: quantifying 'living' in 3D-printable engineered living material based on Pluronic F-127 and yeast Saccharomyces cerevisiae.
Bojan Žunar, Taiga Ito, Christine Mosrin, Yoshiyuki Sugahara, Hélène Bénédetti

Biomater Res· December 2022

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Re-engineering of CUP1 promoter and Cup2/Ace1 transactivator to convert Saccharomyces cerevisiae into a whole-cell eukaryotic biosensor capable of detecting 10 nM of bioavailable copper.
Bojan Žunar, Christine Mosrin, Héléne Bénédetti, Béatrice Vallée

Biosens Bioelectron· October 2022

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LIM Kinases, Promising but Reluctant Therapeutic Targets: Chemistry and Preclinical Validation In Vivo.
Rayan Berabez, Sylvain Routier, Hélène Bénédetti, Karen Plé, Béatrice Vallée

Cells· June 2022

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Design, Synthesis and SAR in 2,4,7-Trisubstituted Pyrido[3,2-]Pyrimidine Series as Novel PI3K/mTOR Inhibitors.
Frédéric Buron, Nuno Rodrigues, Thibault Saurat, Marie Aude Hiebel, Stéphane Bourg

Molecules· September 2021

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The GTPase-activating protein-related domain of neurofibromin interacts with MC1R and regulates pigmentation-mediated signaling in human melanocytes.
Wissem Deraredj Nadim, Shalina Hassanaly, Hélène Bénédetti, Claudine Kieda, Catherine Grillon

Biochem Biophys Res Commun· January 2021

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A straightforward methodology to overcome solubility challenges for N-terminal cysteinyl peptide segments used in native chemical ligation.
Skander A Abboud, El Hadji Cisse, Michel Doudeau, Hélène Bénédetti, Vincent Aucagne

Chem Sci· January 2021

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Neurofibromin Structure, Functions and Regulation.
Mohammed Bergoug, Michel Doudeau, Fabienne Godin, Christine Mosrin, Béatrice Vallée

Cells· October 2020

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Characterization at the Molecular Level using Robust Biochemical Approaches of a New Kinase Protein.
Béatrice Vallée, Michel Doudeau, Fabienne Godin, Hélène Bénédetti

J Vis Exp· June 2019

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LIMK2-1 is a Hominidae-Specific Isoform of LIMK2 Expressed in Central Nervous System and Associated with Intellectual Disability.
Julie Tastet, Hélène Cuberos, Béatrice Vallée, Annick Toutain, Martine Raynaud

Neuroscience· February 2019

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LIMK2-1, a new isoform of human LIMK2, regulates actin cytoskeleton remodeling via a different signaling pathway than that of its two homologs, LIMK2a and LIMK2b.
Béatrice Vallée, Hélène Cuberos, Michel Doudeau, Fabienne Godin, David Gosset

Biochem J· December 2018

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MicroRNAs in Neurocognitive Dysfunctions: New Molecular Targets for Pharmacological Treatments?
Wissem Deraredj Nadim, Viorel Simion, Helene Benedetti, Chantal Pichon, Patrick Baril

Curr Neuropharmacol· February 2017

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Pharmacomodulation of microRNA Expression in Neurocognitive Diseases: Obstacles and Future Opportunities.
Viorel Simion, Wissem Deraredj Nadim, Helene Benedetti, Chantal Pichon, Severine Morisset-Lopez

Curr Neuropharmacol· February 2017

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Physical interaction between neurofibromin and serotonin 5-HT6 receptor promotes receptor constitutive activity.
Wissem Deraredj Nadim, Séverine Chaumont-Dubel, Fahima Madouri, Laetitia Cobret, Marie-Ludivine De Tauzia

Proc Natl Acad Sci U S A· October 2016

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Mutation screening of the ubiquitin ligase gene RNF135 in French patients with autism.
Julie Tastet, Loïc Decalonne, Sylviane Marouillat, Joëlle Malvy, Rose-Anne Thépault

Psychiatr Genet· December 2015

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Synthesis of new pyridazino[4,5-b]indol-4-ones and pyridazin-3(2H)-one analogs as DYRK1A inhibitors.
Amélie Bruel, Romain Bénéteau, Mylène Chabanne, Olivier Lozach, Rémy Le Guevel

Bioorg Med Chem Lett· November 2014

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New in-capillary electrophoretic kinase assays to evaluate inhibitors of the PI3k/Akt/mTOR signaling pathway.
Reine Nehmé, Hala Nehmé, Thibault Saurat, Marie-Ludivine de-Tauzia, Frédéric Buron

Anal Bioanal Chem· June 2014

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Design, synthesis, and biological activity of pyridopyrimidine scaffolds as novel PI3K/mTOR dual inhibitors.
Thibault Saurat, Frédéric Buron, Nuno Rodrigues, Marie-Ludivine de Tauzia, Lionel Colliandre

J Med Chem· February 2014

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Characterization of histidine-aspartate kinase HK1 and identification of histidine phosphotransfer proteins as potential partners in a Populus multistep phosphorelay.
François Héricourt, Françoise Chefdor, Lucie Bertheau, Mirai Tanigawa, Tatsuya Maeda

Physiol Plant· October 2013

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Nf1 RasGAP inhibition of LIMK2 mediates a new cross-talk between Ras and Rho pathways.
Béatrice Vallée, Michel Doudeau, Fabienne Godin, Aurélie Gombault, Aurélie Tchalikian

PLoS One· April 2013

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Synthesis and biological evaluation of new 5-benzylated 4-oxo-3,4-dihydro-5H-pyridazino[4,5-b]indoles as PI3Kα inhibitors.
Amélie Bruel, Cédric Logé, Marie-Ludivine de Tauzia, Myriam Ravache, Rémy Le Guevel

Eur J Med Chem· November 2012

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Interaction proteomics suggests a new role for the Tfs1 protein in yeast.
Martine Beaufour, Fabienne Godin, Béatrice Vallée, Martine Cadene, Hélène Bénédetti

J Proteome Res· June 2012

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