Publications by authors named "Helene Rudyk"

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Defining Target Engagement Required for Efficacy at the Retinoic Acid Receptor-Related Orphan Receptor C2 (RORγt).
Charles W Lugar, Christian A Clarke, Richard Morphy, Helene Rudyk, Selma Sapmaz

J Med Chem· May 2021

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Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist.
James A Monn, Lourdes Prieto, Lorena Taboada, Junliang Hao, Matthew R Reinhard, Helene Rudyk

J Med Chem· September 2015

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Synthesis and pharmacological characterization of C4-disubstituted analogs of 1S,2S,5R,6S-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: identification of a potent, selective metabotropic glutamate receptor agonist and determination of agonist-bound human mGlu2 and mGlu3 amino terminal domain structures.
James A Monn, Lourdes Prieto, Lorena Taboada, Concepcion Pedregal, Junliang Hao, Helene Rudyk

J Med Chem· February 2015

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Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator.
Junliang Hao, Veronique Dehlinger, Adam M Fivush, Helene C E Rudyk, Thomas C Britton

Bioorg Med Chem Lett· March 2013

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Exploiting domino enyne metathesis mechanisms for skeletal diversity generation.
Richard J Spandl, Hèléne Rudyk, David R Spring

Chem Commun (Camb)· July 2008

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Anti-MRSA agent discovery using diversity-oriented synthesis.
Gemma L Thomas, Richard J Spandl, Freija G Glansdorp, Martin Welch, Andreas Bender, Hélène Rudyk

Angew Chem Int Ed Engl· April 2008

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Discovery and SAR studies of novel GlyT1 inhibitors.
Magnus W Walter, Beth J Hoffman, Kimberly Gordon, Kirk Johnson, Patrick Love, Helene C Rudyk

Bioorg Med Chem Lett· September 2007

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Synthesis of 11C-labelled (R)-OHDMI and CFMME and their evaluation as candidate radioligands for imaging central norepinephrine transporters with PET.
Magnus Schou, Victor W Pike, Judit Sóvágó, Balázs Gulyás, Peter T Gallagher, Helene Rudyk

Bioorg Med Chem· January 2007

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Discovery and structure-activity relationships of novel selective norepinephrine and dual serotonin/norepinephrine reuptake inhibitors.
John Boot, Manuel Cases, Barry P Clark, Jeremy Findlay, Peter T Gallagher, Hélène Rudyk

Bioorg Med Chem Lett· February 2005

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Synthesis of analogues of Congo red and evaluation of their anti-prion activity.
Shane Sellarajah, Tamuna Lekishvili, Claire Bowring, Andrew R Thompsett, Helene Rudyk

J Med Chem· October 2004

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Synthesis and evaluation of analogues of Congo red as potential compounds against transmissible spongiform encephalopathies.
Hélène Rudyk, Michael H Knaggs, Snezana Vasiljevic, James Hope, Chris Birkett

Eur J Med Chem· June 2003

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In vitro cell-free conversion of bacterial recombinant PrP to PrPres as a model for conversion.
Louise Kirby, Christopher R Birkett, Helene Rudyk, Ian H Gilbert, James Hope

J Gen Virol· April 2003

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