Publications by authors named "Richard Morphy"

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Defining Target Engagement Required for Efficacy at the Retinoic Acid Receptor-Related Orphan Receptor C2 (RORγt).
Charles W Lugar, Christian A Clarke, Richard Morphy, Helene Rudyk, Selma Sapmaz

J Med Chem· May 2021

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Synthesis and SAR studies of novel 2-(6-aminomethylaryl-2-aryl-4-oxo-quinazolin-3(4H)-yl)acetamide vasopressin V1b receptor antagonists.
Susan E Napier, Jeffrey J Letourneau, Nasrin Ansari, Douglas S Auld, James Baker, J Richard Morphy

Bioorg Med Chem Lett· June 2011

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Identification and optimisation of novel sulfonamide, selective vasopressin V1B receptor antagonists.
James Baker, Matilda Bingham, Ruth Blackburn-Munro, Jiaqiang Cai, Mark Craighead, J Richard Morphy

Bioorg Med Chem Lett· June 2011

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Synthesis and SAR studies of novel 2-(4-oxo-2-aryl-quinazolin-3(4H)-yl)acetamide vasopressin V1b receptor antagonists.
Susan E Napier, Jeffrey J Letourneau, Nasrin Ansari, Douglas S Auld, James Baker, J Richard Morphy

Bioorg Med Chem Lett· March 2011

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Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.
Peter Ray, Jane Wright, Julia Adam, Sylviane Boucharens, Darcey Black, Richard Morphy

Bioorg Med Chem Lett· February 2011

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The identification, and optimisation of hERG selectivity, of a mixed NET/SERT re-uptake inhibitor for the treatment of pain.
Derek Angus, Matilda Bingham, Dawn Buchanan, Neil Dunbar, Linsday Gibson, Richard Morphy

Bioorg Med Chem Lett· January 2011

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Discovery and optimisation of a selective non-steroidal glucocorticoid receptor antagonist.
Angus R Brown, Michael Bosies, Helen Cameron, John Clark, Angela Cowley, J Richard Morphy

Bioorg Med Chem Lett· January 2011

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Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.
Peter Ray, Jane Wright, Julia Adam, Johnathan Bennett, Sylviane Boucharens, Richard Morphy

Bioorg Med Chem Lett· January 2011

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Design, synthesis, and structure-activity relationship study of bicyclic piperazine analogs of indole-3-carboxamides as novel cannabinoid CB1 receptor agonists.
Elizabeth M Moir, Kazuya Yoshiizumi, Jim Cairns, Phillip Cowley, Morag Ferguson, Richard Morphy

Bioorg Med Chem Lett· December 2010

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Identification and optimization of novel 2-(4-oxo-2-aryl-quinazolin-3(4H)-yl)acetamide vasopressin V3 (V1b) receptor antagonists.
Jeffrey J Letourneau, Christopher M Riviello, Hong Li, Andrew G Cole, Koc-Kan Ho, J Richard Morphy

Bioorg Med Chem Lett· September 2010

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Selectively nonselective kinase inhibition: striking the right balance.
Richard Morphy

J Med Chem· February 2010

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Designing multiple ligands - medicinal chemistry strategies and challenges.
Richard Morphy, Zoran Rankovic

Curr Pharm Des· May 2009

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Fragments, network biology and designing multiple ligands.
Richard Morphy, Zoran Rankovic

Drug Discov Today· February 2007

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The physicochemical challenges of designing multiple ligands.
Richard Morphy, Zoran Rankovic

J Med Chem· August 2006

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The influence of target family and functional activity on the physicochemical properties of pre-clinical compounds.
Richard Morphy

J Med Chem· May 2006

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Designed multiple ligands. An emerging drug discovery paradigm.
Richard Morphy, Zoran Rankovic

J Med Chem· October 2005

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Synthesis and SAR studies of 3-phenoxypropyl piperidine analogues as ORL1 (NOP) receptor agonists.
Ronald Palin, David R Barn, John K Clark, Jean E Cottney, Phillip M Cowley, Richard J Morphy

Bioorg Med Chem Lett· February 2005

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From magic bullets to designed multiple ligands.
Richard Morphy, Corinne Kay, Zoran Rankovic

Drug Discov Today· August 2004

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2-(Aminomethyl)-benzamide-based glycine transporter type-2 inhibitors.
Koc-Kan Ho, Kenneth C Appell, John J Baldwin, Adolph C Bohnstedt, Guizhen Dong, J Richard Morphy

Bioorg Med Chem Lett· January 2004

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Optimization of reaction conditions for REM resin-bound quaternization reactions.
Kenneth S Cameron, J Richard Morphy, Zoran Rankovic, Mark York

J Comb Chem· July 2003

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