Publications by authors named "Herman D Lim"

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Identification of a Lipid-Exposed Extrahelical Binding Site for Positive Allosteric Modulators of the Dopamine D Receptor.
Herman D Lim, Damian Bartuzi, Alastair C Keen, Caroline Rauffenbart, Jacqueline Glenn

ACS Chem Neurosci· June 2025

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The chemokine receptor CCR8 is not a high-affinity receptor for the human chemokine CCL18.
Khansa Hussain, Herman D Lim, Shankar Raj Devkota, Barbara K Kemp-Harper, J Robert Lane

PLoS One· September 2024

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Identification and Characterization of ML321: A Novel and Highly Selective D Dopamine Receptor Antagonist with Efficacy in Animal Models That Predict Atypical Antipsychotic Activity.
R Benjamin Free, Ashley N Nilson, Noelia M Boldizsar, Trevor B Doyle, Ramona M Rodriguiz, Herman D Lim

ACS Pharmacol Transl Sci· January 2023

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Structure-guided engineering of tick evasins for targeting chemokines in inflammatory diseases.
Ram Prasad Bhusal, Pramod Aryal, Shankar Raj Devkota, Rina Pokhrel, Menachem J Gunzburg, Herman D Lim

Proc Natl Acad Sci U S A· March 2022

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Systematic Assessment of Chemokine Signaling at Chemokine Receptors CCR4, CCR7 and CCR10.
Herman D Lim, J Robert Lane, Meritxell Canals, Martin J Stone

Int J Mol Sci· April 2021

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Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists.
Alexander Gillis, Arisbel B Gondin, Andrea Kliewer, Julie Sanchez, Herman D Lim

Sci Signal· March 2020

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Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism.
J Robert Lane, Ara M Abramyan, Pramisha Adhikari, Alastair C Keen, Kuo-Hao Lee, Herman D Lim

Elife· January 2020

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Molecular Determinants of the Intrinsic Efficacy of the Antipsychotic Aripiprazole.
Carmen Klein Herenbrink, Ravi Verma, Herman D Lim, Anitha Kopinathan, Alastair Keen

ACS Chem Biol· August 2019

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A Thieno[2,3- d]pyrimidine Scaffold Is a Novel Negative Allosteric Modulator of the Dopamine D Receptor.
Tim J Fyfe, Barbara Zarzycka, Herman D Lim, Barrie Kellam, Shailesh N Mistry

J Med Chem· January 2019

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Key determinants of selective binding and activation by the monocyte chemoattractant proteins at the chemokine receptor CCR2.
Zil E Huma, Julie Sanchez, Herman D Lim, Jessica L Bridgford, Cheng Huang

Sci Signal· May 2017

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Proof of concept study for designed multiple ligands targeting the dopamine D2, serotonin 5-HT2A, and muscarinic M1 acetylcholine receptors.
Monika Szabo, Herman D Lim, Carmen Klein Herenbrink, Arthur Christopoulos, J Robert Lane

J Med Chem· February 2015

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A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: comparison of hERG binding and target residence time with PF-3893787.
Mounir Andaloussi, Herman D Lim, Tiffany van der Meer, Maarten Sijm, Chris B M Poulie

Bioorg Med Chem Lett· May 2013

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Ligand based design of novel histamine H₄ receptor antagonists; fragment optimization and analysis of binding kinetics.
Rogier A Smits, Herman D Lim, Tiffany van der Meer, Sebastiaan Kuhne, Karin Bessembinder

Bioorg Med Chem Lett· January 2012

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Identification of a novel allosteric binding site in the CXCR2 chemokine receptor.
Petra de Kruijf, Herman D Lim, Luc Roumen, Véronique A Renjaän, Jiuqiao Zhao

Mol Pharmacol· December 2011

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Several down, a few to go: histamine H3 receptor ligands making the final push towards the market?
Sebastiaan Kuhne, Maikel Wijtmans, Herman D Lim, Rob Leurs, Iwan J P de Esch

Expert Opin Investig Drugs· December 2011

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Molecular determinants of ligand binding modes in the histamine H(4) receptor: linking ligand-based three-dimensional quantitative structure-activity relationship (3D-QSAR) models to in silico guided receptor mutagenesis studies.
Enade P Istyastono, Saskia Nijmeijer, Herman D Lim, Andrea van de Stolpe, Luc Roumen

J Med Chem· December 2011

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N-acetylated Proline-Glycine-Proline induced G-protein dependent chemotaxis of neutrophils is independent of CXCL8 release.
Saskia A Overbeek, Paul A J Henricks, Anja I Srienc, Pim J Koelink, Petra de Kruijf, Herman D Lim

Eur J Pharmacol· October 2011

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The collagen-breakdown product N-acetyl-Proline-Glycine-Proline (N-alpha-PGP) does not interact directly with human CXCR1 and CXCR2.
Petra de Kruijf, Herman D Lim, Saskia A Overbeek, Guido J R Zaman, Aletta D Kraneveld

Eur J Pharmacol· September 2010

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Molecular determinants of ligand binding to H4R species variants.
Herman D Lim, Chris de Graaf, Wen Jiang, Payman Sadek, Patricia M McGovern

Mol Pharmacol· May 2010

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Clobenpropit analogs as dual activity ligands for the histamine H3 and H4 receptors: synthesis, pharmacological evaluation, and cross-target QSAR studies.
Herman D Lim, Enade P Istyastono, Andrea van de Stolpe, Giuseppe Romeo, Silvia Gobbi

Bioorg Med Chem· June 2009

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Nonpeptidergic allosteric antagonists differentially bind to the CXCR2 chemokine receptor.
Petra de Kruijf, Jane van Heteren, Herman D Lim, Paolo G M Conti, Miranda M C van der Lee

J Pharmacol Exp Ther· May 2009

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Molecular and biochemical pharmacology of the histamine H4 receptor.
Rob Leurs, Paul L Chazot, Fiona C Shenton, Herman D Lim, Iwan J P de Esch

Br J Pharmacol· May 2009

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Pharmacological characterization of the new histamine H4 receptor agonist VUF 8430.
Herman D Lim, Maristella Adami, Elena Guaita, Thomas Werfel, Rogier A Smits

Br J Pharmacol· May 2009

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Phenylalanine 169 in the second extracellular loop of the human histamine H4 receptor is responsible for the difference in agonist binding between human and mouse H4 receptors.
Herman D Lim, Aldo Jongejan, Remko A Bakker, Eric Haaksma, Iwan J P de Esch

J Pharmacol Exp Ther· October 2008

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Cloning and pharmacological characterization of the dog histamine H4 receptor.
Wen Jiang, Herman D Lim, Mai Zhang, Pragnya Desai, Heng Dai

Eur J Pharmacol· September 2008

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