Publications by authors named "Remko A Bakker"

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Design of an in situ forming methylcellulose hydrogel as universal vehicle for preclinical intravitreal injection of particulate formulations.
Marco Block, Grazia Giorgio, Christoph Saal, Remko A Bakker, Achim Goepferich

Eur J Pharm Sci· October 2025

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Surface-coated silica microparticles: In vitro and ex vivo evaluation of a preclinical extended release platform conceived for intravitreal injection.
Marco Block, Achim Grube, Achim Göpferich, Christoph Saal, Blessing C Ilochonwu, Remko A Bakker

J Control Release· May 2025

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Non-canonical roles of CFH in retinal pigment epithelial cells revealed by dysfunctional rare CFH variants.
Sofie C A ten Brink, Louet Koolen, Caroline C W Klaver, Remko A Bakker, Anneke I den Hollander

Stem Cell Reports· January 2025

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BI-Y, an Neuropilin-1 Antagonist, Enhances Revascularization and Prevents Vascular Endothelial Growth Factor-A Induced Retinal Hyperpermeability in Rodent Models of Retinopathies.
Leo Thomas, Sarah Low, Gale Hansen, Remko A Bakker, Nina Zippel

J Pharmacol Exp Ther· June 2023

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Transcriptome analysis of AAV-induced retinopathy models expressing human VEGF, TNF-α, and IL-6 in murine eyes.
Kolja Becker, Carina M Weigelt, Holger Fuchs, Coralie Viollet, Werner Rust, Remko A Bakker

Sci Rep· November 2022

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Transcriptional comparison of adult human primary Retinal Pigment Epithelium, human pluripotent stem cell-derived Retinal Pigment Epithelium, and ARPE19 cells.
Elke K Markert, Holger Klein, Coralie Viollet, Werner Rust, Benjamin Strobel, Remko A Bakker

Front Cell Dev Biol· August 2022

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Efficacy of an Anti-Semaphorin 3A Neutralizing Antibody in a Male Experimental Retinal Vein Occlusion Mouse Model.
Shinsuke Nakamura, Anri Nishinaka, Yae Hidaka, Masamitsu Shimazawa, Leo Thomas, Remko A Bakker

Invest Ophthalmol Vis Sci· July 2022

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Sema3A Antibody BI-X Prevents Cell Permeability and Cytoskeletal Collapse in HRMECs and Increases Tip Cell Density in Mouse Oxygen-Induced Retinopathy.
Nina Zippel, Cynthia Hess Kenny, Helen Wu, Michel Garneau, Rachel Kroe-Barrett, Remko A Bakker

Transl Vis Sci Technol· June 2022

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Characterization and Validation of In Vitro and In Vivo Models to Investigate TNF-α-Induced Inflammation in Retinal Diseases.
Carina M Weigelt, Nina Zippel, Holger Fuchs, Anna-Kaisa Rimpelä, Tanja Schönberger, Remko A Bakker

Transl Vis Sci Technol· May 2022

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AAV-Mediated Expression of Human VEGF, TNF-α, and IL-6 Induces Retinal Pathology in Mice.
Carina M Weigelt, Holger Fuchs, Tanja Schönberger, Birgit Stierstorfer, Benjamin Strobel, Remko A Bakker

Transl Vis Sci Technol· September 2021

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Evaluation of an Intravitreal Rho-Associated Kinase Inhibitor Depot Formulation in a Rat Model of Diabetic Retinopathy.
Cecile Lebon, Heike Neubauer, Marianne Berdugo, Kimberley Delaunay, Elke Markert, Remko A Bakker

Pharmaceutics· July 2021

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In-depth transcriptomic analysis of human retina reveals molecular mechanisms underlying diabetic retinopathy.
Kolja Becker, Holger Klein, Eric Simon, Coralie Viollet, Christian Haslinger, Remko A Bakker

Sci Rep· May 2021

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Amine oxidase copper-containing 3 (AOC3) inhibition: a potential novel target for the management of diabetic retinopathy.
David S Boyer, Joerg F Rippmann, Michael S Ehrlich, Remko A Bakker, Victor Chong

Int J Retina Vitreous· April 2021

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A Single Second Shell Amino Acid Determines Affinity and Kinetics of Linagliptin Binding to Type 4 Dipeptidyl Peptidase and Fibroblast Activation Protein.
Gisela Schnapp, Yvette Hoevels, Remko A Bakker, Patrick Schreiner, Thomas Klein

ChemMedChem· February 2021

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Comparative Analysis of Binding Kinetics and Thermodynamics of Dipeptidyl Peptidase-4 Inhibitors and Their Relationship to Structure.
Gisela Schnapp, Thomas Klein, Yvette Hoevels, Remko A Bakker, Herbert Nar

J Med Chem· August 2016

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Differential inverse agonism at the human muscarinic M₃ receptor.
Paola Casarosa, Tobias Kiechle, Remko A Bakker

Methods Enzymol· March 2011

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A structural insight into the reorientation of transmembrane domains 3 and 5 during family A G protein-coupled receptor activation.
Kamonchanok Sansuk, Xavier Deupi, Ivan R Torrecillas, Aldo Jongejan, Saskia Nijmeijer, Remko A Bakker

Mol Pharmacol· February 2011

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Molecular determinants of ligand binding to H4R species variants.
Herman D Lim, Chris de Graaf, Wen Jiang, Payman Sadek, Patricia M McGovern, Remko A Bakker

Mol Pharmacol· May 2010

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Clobenpropit analogs as dual activity ligands for the histamine H3 and H4 receptors: synthesis, pharmacological evaluation, and cross-target QSAR studies.
Herman D Lim, Enade P Istyastono, Andrea van de Stolpe, Giuseppe Romeo, Silvia Gobbi, Remko A Bakker

Bioorg Med Chem· June 2009

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Pharmacological characterization of the new histamine H4 receptor agonist VUF 8430.
Herman D Lim, Maristella Adami, Elena Guaita, Thomas Werfel, Rogier A Smits, Remko A Bakker

Br J Pharmacol· May 2009

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Phenylalanine 169 in the second extracellular loop of the human histamine H4 receptor is responsible for the difference in agonist binding between human and mouse H4 receptors.
Herman D Lim, Aldo Jongejan, Remko A Bakker, Eric Haaksma, Iwan J P de Esch

J Pharmacol Exp Ther· October 2008

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Cloning and characterization of dominant negative splice variants of the human histamine H4 receptor.
Richard M van Rijn, André van Marle, Paul L Chazot, Ellen Langemeijer, Yongjun Qin, Remko A Bakker

Biochem J· August 2008

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4-benzyl-1H-imidazoles with oxazoline termini as histamine H3 receptor agonists.
Maikel Wijtmans, Sylvain Celanire, Erwin Snip, Michel R Gillard, Edith Gelens, Remko A Bakker

J Med Chem· May 2008

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GPCR proteomics: mass spectrometric and functional analysis of histamine H1 receptor after baculovirus-driven and in vitro cell free expression.
Kamonchanok Sansuk, Crina I A Balog, Anne M van der Does, Raymond Booth, Willem J de Grip, Remko A Bakker

J Proteome Res· February 2008

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A flow-through fluorescence polarization detection system for measuring GPCR-mediated modulation of cAMP production.
Jeroen Kool, André van Marle, Saskia Hulscher, Maurice Selman, Dick J van Iperen, Remko A Bakker

J Biomol Screen· December 2007

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