Publications by authors named "Herman Overkleeft"

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Structure-Based Design of Pan-Selective Peptide Epoxyketones for the Three Human Immunoproteasome Active Sites.
Patrick M Dekker, Eva M Huber, Elmer Maurits, Xingzao Wang, Wolfgang Heinemeyer, Herman S Overkleeft

J Med Chem· January 2026

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Inhibitors of the 20S proteasome β5 subunit as potent and selective agents against .
Yukiko Miyamoto, Brianna M Hurysz, Pavla Fajtova, Peter Eckmann, Mateus Sá Magalhães Serafim, Herman S Overkleeft

Antimicrob Agents Chemother· December 2025

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LIMP-2 deficiency-associated glycolipid abnormalities in mice.
Paulo Gaspar, André R A Marques, Maria J Ferraz, Markus Damme, Gertjan Kramer, Herman S Overkleeft

Biochim Biophys Acta Mol Cell Biol Lipids· October 2025

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Synthesis, Conformal Analysis, and Antibody Binding of Staphylococcus aureus Capsular Polysaccharide Type 5 Oligosaccharides.
Kitt E Østerlid, Sizhe Li, Luca Unione, Linda Del Bino, Charlotte Sorieul, Herman S Overkleeft

Angew Chem Int Ed Engl· September 2025

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Carfilzomib-specific proteasome β5/β2 inhibition drives cardiotoxicity via remodeling of protein homeostasis and the renin-angiotensin-system.
Max Mendez-Lopez, Andrej Besse, Christian Zuppinger, Christian Perez-Shibayama, Cristina Gil-Cruz, Herman S Overkleeft

iScience· September 2025

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Manipulating anthracyclines for deeper tissue penetration and implications for glycolytic tissues.
Erik R Abels, Esther Ter Linden, Jos H T Rohling, Lennard M Voortman, Lennert Janssen, Herman S Overkleeft

Proc Natl Acad Sci U S A· September 2025

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-Branched Iminosugars as Selective Pharmacological Chaperones of Lysosomal α-Glucosidase for the Treatment of Pompe Disease.
Anaïs Vieira Da Cruz, Valentine Perraudin, Nadia Minopoli, Roberta Iacono, Véronique Roig-Zamboni, Herman S Overkleeft

J Med Chem· September 2025

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Activity-Based Profiling of Retaining Glycosidases in Disease Diagnosis and Their Application in Drug Discovery.
Yevhenii Radchenko, Johannes M F G Aerts, Gideon J Davies, Jeroen D C Codée, Herman S Overkleeft

Handb Exp Pharmacol· August 2025

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Convergent Approach Toward ADP-Ribosylated Peptides via a Chemoselective Phosphate Condensation.
Sven Wijngaarden, Femke L A M van der Heijden, Cindy J Bogaart, Maria Siskou, Ioanna Tsoumani, Herman S Overkleeft

Chemistry· July 2025

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Activity-based probes for dynamic characterisation of polysaccharide-degrading enzymes.
Isabelle B Pickles, Thamy L R Corrêa, Herman S Overkleeft, Gideon J Davies

Biochem J· July 2025

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Synthesis of a Set of Staphylococcus Aureus Capsular Polysaccharide Type 1 Oligosaccharides Carrying Taurine Esters.
Kitt Emilie Østerlid, Renata Cergano, Herman S Overkleeft, Gijsbert A van der Marel, Jeroen D C Codée

Chemistry· April 2025

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Activity-Based Protein Profiling Identifies an α-Amylase Family Protein Contributing to the Virulence of Methicillin-Resistant .
Md Jalal Uddin, Kjersti Julin, Herman S Overkleeft, Mona Johannessen, Christian S Lentz

ACS Infect Dis· March 2025

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Bespoke Activity-Based Probes Reveal that the Endoglycosidase, PslG, Is an Endo-β-glucanase.
Gijs Ruijgrok, Wendy A Offen, Isabelle B Pickles, Deepa Raju, Thanasis Patsos, Herman S Overkleeft

J Am Chem Soc· March 2025

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Precision Activity-Based α-Amylase Probes for Dissection and Annotation of Linear and Branched-Chain Starch-Degrading Enzymes.
Isabelle B Pickles, Yurong Chen, Olga Moroz, Haley A Brown, Casper de Boer, Herman S Overkleeft

Angew Chem Int Ed Engl· January 2025

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Long, Synthetic Type 8 Capsular Oligosaccharides Reveal Structural Epitopes for Effective Immune Recognition.
Kitt Emilie Østerlid, Charlotte Sorieul, Luca Unione, Sizhe Li, Cristian García-Sepúlveda, Herman S Overkleeft

J Am Chem Soc· January 2025

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Synthesis and Biological Evaluation of Deoxycyclophellitols as Human Retaining β-Glucosidase Inhibitors.
Yevhenii Radchenko, Qin Su, Sybrin S Schröder, Luke van Gijlswijk, Marta Artola, Herman S Overkleeft

Chemistry· December 2024

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6-O-alkyl 4-methylumbelliferyl-β-D-glucosides as selective substrates for GBA1 in the discovery of glycosylated sterols.
Stef Bannink, Kateryna O Bila, Joosje van Weperen, Nina A M Ligthart, Maria J Ferraz, Herman S Overkleeft

J Lipid Res· November 2024

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Structure-guided design of C3-branched swainsonine as potent and selective human Golgi α-mannosidase (GMII) inhibitor.
Tony Koemans, Megan Bennett, Maria J Ferraz, Zachary Armstrong, Marta Artola, Herman S Overkleeft

Chem Commun (Camb)· October 2024

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Human milk oligosaccharide 2'-fucosyllactose protects against high-fat diet-induced obesity by changing intestinal mucus production, composition and degradation linked to changes in gut microbiota and faecal proteome profiles in mice.
Paola Paone, Dimitris Latousakis, Romano Terrasi, Didier Vertommen, Ching Jian, Herman Overkleeft

Gut· September 2024

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From Mechanism-Based Retaining Glycosidase Inhibitors to Activity-Based Glycosidase Profiling.
Marta Artola, Johannes M F G Aerts, Gijsbert A van der Marel, Carme Rovira, Jeroen D C Codée, Herman S Overkleeft

J Am Chem Soc· September 2024

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Selective labelling of GBA2 in cells with fluorescent β-d-arabinofuranosyl cyclitol aziridines.
Qin Su, Max Louwerse, Rob F Lammers, Elmer Maurits, Max Janssen, Herman S Overkleeft

Chem Sci· September 2024

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A PIKfyve modulator combined with an integrated stress response inhibitor to treat lysosomal storage diseases.
William C Hou, Lynée A Massey, Derek Rhoades, Yin Wu, Wen Ren, Herman S Overkleeft

Proc Natl Acad Sci U S A· August 2024

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-Cyclophellitol Cyclosulfate, a Mechanism-Based Endoplasmic Reticulum α-Glucosidase II Inhibitor, Blocks Replication of SARS-CoV-2 and Other Coronaviruses.
Melissa Thaler, Tim P Ofman, Ken Kok, Jurriaan J A Heming, Elisha Moran, Herman S Overkleeft

ACS Cent Sci· August 2024

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NO1 tailors its secretome for different lignocellulosic substrates.
Conor J R Scott, Nicholas G S McGregor, Daniel R Leadbeater, Nicola C Oates, Janina Hoßbach, Herman S Overkleeft

Microbiol Spectr· July 2024

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Detection of Sulfoquinovosidase Activity in Cell Lysates Using Activity-Based Probes.
Zirui Li, Isabelle B Pickles, Mahima Sharma, Benjamin Melling, Luise Pallasdies, Herman S Overkleeft

Angew Chem Int Ed Engl· June 2024

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