Publications by authors named "Hermann Tenor"

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The combined treatment with TOP-V122, a dual-acting NO-releasing PDE-5 inhibitor, and ionizing irradiation as a novel therapeutical strategy for colorectal carcinoma.
Alba Sanchez-Fernandez, Hermann Tenor, Claire Beckers, Chantal Pauli, Zuzana Garajova

Radiother Oncol· December 2025

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Patient-convenient long-term alopecia treatment PLGA microsphere-loaded candlelit microneedles.
Jiwoo Shin, Sung Min Cho, Youseong Kim, Geonwoo Kang, Tobias Braun, Hermann Tenor

J Mater Chem B· May 2025

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Distinct Impact of Phosphodiesterade-4 (PDE4) Inhibition in Two Pre-clinical Psoriasis Models.
Sören Dräger, Thorge Mester, Hermann Tenor, Ralf J Ludwig, Katja Bieber

Acta Derm Venereol· April 2025

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Bifunctional Sildenafil Diazeniumdiolates Acting as Phosphodiesterase 5 Inhibitors and Nitric Oxide Donors- Towards Wound Healing.
Josep Mas-Roselló, Hermann Tenor, Timea Szabo, Reto Naef, Simon Sieber

Chembiochem· April 2024

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The IL-4/13-induced production of M2 chemokines by human lung macrophages is enhanced by adenosine and PGE.
Marion Brollo, Hélène Salvator, Stanislas Grassin-Delyle, Mathieu Glorion, Delphyne Descamps, Hermann Tenor

Int Immunopharmacol· February 2024

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Topical Wound Treatment with a Nitric Oxide-Releasing PDE5 Inhibitor Formulation Enhances Blood Perfusion and Promotes Healing in Mice.
Maya Ben-Yehuda Greenwald, Yu-Hang Liu, Weiye Li, Paul Hiebert, Maria Zubair, Hermann Tenor

Pharmaceutics· October 2022

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Clinical relevance of the relaxant effects of roflumilast on human bronchus: potentiation by a long-acting beta-2-agonist.
Hélène Salvator, Emmanuel Naline, Marion Brollo, Hermann Tenor, Stanislas Grassin-Delyle

Fundam Clin Pharmacol· August 2021

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A Dual-Acting Nitric Oxide Donor and Phosphodiesterase 5 Inhibitor Promotes Wound Healing in Normal Mice and Mice with Diabetes.
Maya Ben-Yehuda Greenwald, Carlotta Tacconi, Marko Jukic, Natasha Joshi, Paul Hiebert, Hermann Tenor

J Invest Dermatol· February 2021

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Clinical Relevance of the Anti-inflammatory Effects of Roflumilast on Human Bronchus: Potentiation by a Long-Acting Beta-2-Agonist.
Hélène Salvator, Amparo Buenestado, Marion Brollo, Emmanuel Naline, Tatiana Victoni, Hermann Tenor

Front Pharmacol· December 2020

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TOP-N53: A Clinical Drug Candidate for the Treatment of Non-healing Wounds.
Reto Naef, Hermann Tenor, Guido Koch

Chimia (Aarau)· October 2020

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Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity.
Antoni R Blaazer, Abhimanyu K Singh, Erik de Heuvel, Ewald Edink, Kristina M Orrling, Hermann Tenor

J Med Chem· May 2018

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PDE4 Inhibition as Potential Treatment of Epidermolysis Bullosa Acquisita.
Hiroshi Koga, Andreas Recke, Gestur Vidarsson, Hendri H Pas, Marcel F Jonkman, Hermann Tenor

J Invest Dermatol· November 2016

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Synthesis and evaluation of analogs of the phenylpyridazinone NPD-001 as potent trypanosomal TbrPDEB1 phosphodiesterase inhibitors and in vitro trypanocidals.
Johan Veerman, Toine van den Bergh, Kristina M Orrling, Chimed Jansen, Paul Cos, Hermann Tenor

Bioorg Med Chem· April 2016

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Roflumilast n-oxide associated with PGE2 prevents the neutrophil elastase-induced production of chemokines by epithelial cells.
Tatiana Victoni, Thomas Gicquel, Aude Bodin, Marion Daude, Hermann Tenor

Int Immunopharmacol· January 2016

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Roflumilast N-oxide prevents cytokine secretion induced by cigarette smoke combined with LPS through JAK/STAT and ERK1/2 inhibition in airway epithelial cells.
Tatiana Victoni, Florence Gleonnec, Manuella Lanzetti, Hermann Tenor, Samuel Valença

PLoS One· September 2014

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Roflumilast inhibits lipopolysaccharide-induced tumor necrosis factor-α and chemokine production by human lung parenchyma.
Amparo Buenestado, Marie-Camille Chaumais, Stanislas Grassin-Delyle, Paul-André Risse, Emmanuel Naline, Hermann Tenor

PLoS One· May 2014

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Downregulation of NOX4 expression by roflumilast N-oxide reduces markers of fibrosis in lung fibroblasts.
Daniela Vecchio, Alessandra Acquaviva, Beatrice Arezzini, Hermann Tenor, Piero A Martorana

Mediators Inflamm· February 2014

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Phosphodiesterase-4 inhibition augments human lung fibroblast vascular endothelial growth factor production induced by prostaglandin E2.
Jun Ikari, Joel M Michalski, Shunichiro Iwasawa, Yoko Gunji, Steve Nogel, Hermann Tenor

Am J Respir Cell Mol Biol· October 2013

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Response to commentary: 'If roflumilast inhibits the innate immunity in the stable patient, what about infection?'.
Amparo Buenestado, Stanislas Grassin-Delyle, Fleur Guitard, Emmanuel Naline, Christophe Faisy, Hermann Tenor

Clin Respir J· July 2013

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Roflumilast-N-oxide induces surfactant protein expression in human alveolar epithelial cells type II.
Kerstin Höhne, Stephan J Schliessmann, Andreas Kirschbaum, Till Plönes, Joachim Müller-Quernheim, Hermann Tenor

PLoS One· March 2013

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Discovery of novel Trypanosoma brucei phosphodiesterase B1 inhibitors by virtual screening against the unliganded TbrPDEB1 crystal structure.
Chimed Jansen, Huanchen Wang, Albert J Kooistra, Chris de Graaf, Kristina M Orrling, Hermann Tenor

J Med Chem· March 2013

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Pharmacological validation of Trypanosoma brucei phosphodiesterases as novel drug targets.
Harry P de Koning, Matthew K Gould, Geert Jan Sterk, Hermann Tenor, Stefan Kunz

J Infect Dis· July 2012

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Phosphodiesterase inhibitors: history of pharmacology.
Christian Schudt, Armin Hatzelmann, Rolf Beume, Hermann Tenor

Handb Exp Pharmacol· September 2011

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Pharmacology, clinical efficacy, and tolerability of phosphodiesterase-4 inhibitors: impact of human pharmacokinetics.
Hermann Tenor, Armin Hatzelmann, Rolf Beume, Gezim Lahu, Karl Zech

Handb Exp Pharmacol· September 2011

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The preclinical pharmacology of roflumilast--a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease.
Armin Hatzelmann, Esteban J Morcillo, Giuseppe Lungarella, Serge Adnot, Shahin Sanjar, Hermann Tenor

Pulm Pharmacol Ther· August 2010

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