Publications by authors named "Hiroyuki Eda"

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Structure-activity relationship study, target identification, and pharmacological characterization of a small molecular IL-12/23 inhibitor, APY0201.
Nobuhiko Hayakawa, Masatsugu Noguchi, Sen Takeshita, Agung Eviryanti, Yukie Seki, Hiroyuki Eda

Bioorg Med Chem· June 2014

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Oral treatment with a novel small molecule alpha 4 integrin antagonist, AJM300, prevents the development of experimental colitis in mice.
Toshihiko Sugiura, Shunsuke Kageyama, Ayatoshi Andou, Tomoko Miyazawa, Chieko Ejima, Hiroyuki Eda

J Crohns Colitis· December 2013

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A novel, orally active alpha 4 integrin antagonist, AJM300 prevents the development of experimental colitis induced by adoptive transfer of IL-10 deficient CD4(+) T cells in mice.
Toshihiko Sugiura, Shunsuke Kageyama, Ayatoshi Andou, Tomoko Miyazawa, Chieko Ejima, Hiroyuki Eda

J Pharmacol Exp Ther· July 2012

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A nanofiber membrane maintains the quiescent phenotype of hepatic stellate cells.
Hiroyuki Eda, Katherine M Kulig, Toni A Steiner, Hideaki Shimada, Krupali Patel

Dig Dis Sci· May 2012

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Proinflammatory cytokines, IL-1β and TNF-α, induce expression of interleukin-34 mRNA via JNK- and p44/42 MAPK-NF-κB pathway but not p38 pathway in osteoblasts.
Hiroyuki Eda, Hideaki Shimada, David R Beidler, Joseph B Monahan

Rheumatol Int· November 2011

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Interleukin-1β-induced interleukin-6 production in A549 cells is mediated by both phosphatidylinositol 3-kinase and interleukin-1 receptor-associated kinase-4.
Hiroyuki Eda, Barry L Burnette, Hideaki Shimada, Heidi R Hope, Joseph B Monahan

Cell Biol Int· April 2011

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Macrophage-colony stimulating factor and interleukin-34 induce chemokines in human whole blood.
Hiroyuki Eda, Jian Zhang, Robert H Keith, Marshall Michener, David R Beidler

Cytokine· December 2010

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Critical role for apoptosis signal-regulating kinase 1 in the development of inflammatory K/BxN serum-induced arthritis.
Stephen J Mnich, Patrick M Blanner, Liangbiao G Hu, Alexander F Shaffer, Fernando A Happa, Hiroyuki Eda

Int Immunopharmacol· October 2010

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Pharmacological characterization and determination of pharmacokinetic and pharmacodynamic relationship of PF-00885706, a novel partial agonist selective for the 5-HT(4) receptor.
Tohru Komada, Tomomi Matsuura, Tadayoshi Mikami, Keiko Suzuki, Hiromi Sugimoto, Hiroyuki Eda

Pharmacol Res· October 2009

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In vitro and in vivo pharmacological characterization of PF-01354082, a novel partial agonist selective for the 5-HT(4) receptor.
Tadayoshi Mikami, Tohru Komada, Hiromi Sugimoto, Keiko Suzuki, Takashi Ohmi, Hiroyuki Eda

Eur J Pharmacol· May 2009

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Selective CB1 cannabinoid receptor antagonist, SR141716A, attenuates liver injury induced by Concanavalin A.
Midori Kojima, Naoto Kato, Daisuke Hirano, Takashi Ochi, Aisuke Nii, Hiroyuki Eda

Hepatol Res· April 2009

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Synthesis and structure-activity relationships of oxamyl dipeptide caspase inhibitors developed for the treatment of liver disease.
Hirokazu Ueno, Makoto Kawai, Hirohisa Shimokawa, Masako Hirota, Masashi Ohmi, Hiroyuki Eda

Bioorg Med Chem Lett· January 2009

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Apoptosis signal-regulating kinase 1 is crucial for oxidative stress-induced but not for osmotic stress-induced hepatocyte cell death.
Kenji Taki, Rieko Shimozono, Hajime Kusano, Nobutaka Suzuki, Katsuhiro Shinjo, Hiroyuki Eda

Life Sci· December 2008

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Analysis of herpes simplex virus type 1 restriction fragment length polymorphism variants associated with herpes gladiatorum and Kaposi's varicelliform eruption in sumo wrestlers.
Fumihiko Ban, Satoe Asano, Shigeru Ozawa, Hiroyuki Eda, James Norman

J Gen Virol· October 2008

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Contribution of active and inactive states of the human 5-HT4d receptor to the functional activities of 5-HT4-receptor agonists.
Tadayoshi Mikami, Hiromi Sugimoto, Rie Naganeo, Takashi Ohmi, Toshiyuki Saito, Hiroyuki Eda

J Pharmacol Sci· July 2008

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Orally-administered caspase inhibitor PF-03491390 is retained in the liver for prolonged periods with low systemic exposure, exerting a hepatoprotective effect against alpha-fas-induced liver injury in a mouse model.
Yoshinobu Ueno, Takashi Ohmi, Mitsuko Yamamoto, Naoto Kato, Yukiko Moriguchi, Hiroyuki Eda

J Pharmacol Sci· October 2007

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The herpes simplex virus type 1 BgKL variant, unlike the BgOL variant, shows a higher association with orolabial infection than with infections at other sites, supporting the variant-dispersion-replacement hypothesis.
Shigeru Ozawa, Hiroyuki Eda, Yasuyuki Ishii, Fumihiko Ban, Toshiyuki Funabashi

J Clin Microbiol· July 2007

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Contrasting geographic distribution profiles of the herpes simplex virus type 1 BgOL and BgKL variants in Japan suggest dispersion and replacement.
Hiroyuki Eda, Shigeru Ozawa, , Kamesaburo Yoshino, Kazuo Yanagi

J Clin Microbiol· March 2007

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Geographical distribution of the herpes simplex virus type 1 BgKL variant in Japan suggests gradual dispersion of the virus from Shikoku Island to the other Islands.
Shigeru Ozawa, Hiroyuki Eda, Kozaburo Hayashi, , Kamesaburo Yoshino

J Clin Microbiol· June 2006

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Monoclonal antibodies against regions topologically surrounding the homodimeric beta-barrel interface of Epstein-Barr virus nuclear antigen-1.
Hiroyuki Eda, Yasuyuki Ishii, Maya Obayashi, Shizuko Harada, Sayuri Ito, Masato Ikeda

Virus Res· April 2005

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Maintenance of serum immunoglobulin G antibodies to Epstein-Barr virus (EBV) nuclear antigen 2 in healthy individuals from different age groups in a Japanese population with a high childhood incidence of asymptomatic primary EBV infection.
Shizuko Harada, Yoshio Kamata, Yasuyuki Ishii, Hiroyuki Eda, Ryo Kitamura

Clin Diagn Lab Immunol· January 2004

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Augmentation of the antitumor activity of capecitabine by a tumor selective dihydropyrimidine dehydrogenase inhibitor, RO0094889.
Mika Endo, Masanori Miwa, Hiroyuki Eda, Masako Ura, Hiromi Tanimura

Int J Cancer· September 2003

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Design and synthesis of the tumor-activated prodrug of dihydropyrimidine dehydrogenase (DPD) inhibitor, RO0094889 for combination therapy with capecitabine.
Kazuo Hattori, Yasunori Kohchi, Nobuhiro Oikawa, Hitomi Suda, Masako Ura, Hiroyuki Eda

Bioorg Med Chem Lett· March 2003

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