Publications by authors named "Hitomi Yuki"

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DNA methylation and multi-omics profiling of T cells uncovers chemotactic pathways and proliferation-linked hypomethylation in narcolepsy type 1.
Mihoko Shimada, Makoto Honda, Yoshiko Honda, Tohru Kodama, Yuki Hitomi

Sleep· December 2025

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A genome-wide association study identified PTPN2 as a population-specific susceptibility gene locus for primary biliary cholangitis.
Yuki Hitomi, Kazuko Ueno, Yoshihiro Aiba, Nao Nishida, Michihiro Kono, Motoyuki Kojima, Naoyuki Fujimori, Yuki Kugiyama, Tomoyuki Suehiro

Hepatology· October 2024

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rs10924104 in the expression enhancer motif of CD58 confers susceptibility to human autoimmune diseases.
Yuki Hitomi, Kazuko Ueno, Yoshihiro Aiba, Nao Nishida, Yosuke Kawai

Hum Genet· January 2024

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Identification of region-specific gene isoforms in the human brain using long-read transcriptome sequencing.
Mihoko Shimada, Yosuke Omae, Akiyoshi Kakita, Ramil Gabdulkhaev, Yuki Hitomi

Sci Adv· January 2024

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Demographic history of Ryukyu islanders at the southern part of the Japanese Archipelago inferred from whole-genome resequencing data.
Kae Koganebuchi, Masatoshi Matsunami, Minako Imamura, Yosuke Kawai, Yuki Hitomi

J Hum Genet· November 2023

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Novel allele associations with susceptibility, staging, symptomatic state, autoimmune hepatitis and hepatocellular carcinoma events for primary biliary cholangitis in the Japanese population.
Seik-Soon Khor, Kazuko Ueno, Nao Nishida, Minae Kawashima, Yosuke Kawai, Yuki Hitomi

Front Immunol· June 2023

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Corrigendum to: "An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs" [J Hepatol 75 (2021) 572-581].
Heather J Cordell, James J Fryett, Kazuko Ueno, Rebecca Darlay, Yoshihiro Aiba, Yuki Hitomi

J Hepatol· April 2023

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Quantum Chemical Interaction Analysis between SARS-CoV-2 Main Protease and Ensitrelvir Compared with Its Initial Screening Hit.
Chiduru Watanabe, Shigenori Tanaka, Yoshio Okiyama, Hitomi Yuki, Tatsuya Ohyama

J Phys Chem Lett· April 2023

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The Genetics of Primary Biliary Cholangitis: A GWAS and Post-GWAS Update.
Yuki Hitomi, Minoru Nakamura

Genes (Basel)· February 2023

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Identifying antibiotics based on structural differences in the conserved allostery from mitochondrial heme-copper oxidases.
Yuya Nishida, Sachiko Yanagisawa, Rikuri Morita, Hideki Shigematsu, Kyoko Shinzawa-Itoh, Hitomi Yuki, Hideyuki Takahashi, Yukihiro Akeda

Nat Commun· December 2022

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Author Correction: Identifying antibiotics based on structural differences in the conserved allostery from mitochondrial heme-copper oxidases.
Yuya Nishida, Sachiko Yanagisawa, Rikuri Morita, Hideki Shigematsu, Kyoko Shinzawa-Itoh, Hitomi Yuki, Hideyuki Takahashi, Yukihiro Akeda

Nat Commun· December 2022

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rs2013278 in the multiple immunological-trait susceptibility locus CD28 regulates the production of non-functional splicing isoforms.
Yuki Hitomi, Yoshihiro Aiba, Kazuko Ueno, Nao Nishida, Yosuke Kawai

Hum Genomics· October 2022

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New antimalarials identified by a cell-based phenotypic approach: Structure-activity relationships of 2,3,4,9-tetrahydro-1H-β-carboline derivatives possessing a 2-((coumarin-5-yl)oxy)alkanoyl moiety.
Nobuo Cho, Ko Kikuzato, Yushi Futamura, Takeshi Shimizu, Hiroki Hayase, Hitomi Yuki, Hiroyuki Osada

Bioorg Med Chem· July 2022

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Genome-Wide Association Study for Chronic Hepatitis B Infection in the Thai Population.
Saeideh Ashouri, Seik-Soon Khor, Yuki Hitomi, Hiromi Sawai, Nao Nishida

Front Genet· June 2022

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Corrigendum to 'An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs' [J Hepatol 2021;75(3):572-581].
Heather J Cordell, James J Fryett, Kazuko Ueno, Rebecca Darlay, Yoshihiro Aiba, Yuki Hitomi

J Hepatol· February 2022

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rs9459874 and rs1012656 in CCR6/FGFR1OP confer susceptibility to primary biliary cholangitis.
Yuki Hitomi, Yoshihiro Aiba, Kazuko Ueno, Nao Nishida, Yosuke Kawai

J Autoimmun· January 2022

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An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs.
Heather J Cordell, James J Fryett, Kazuko Ueno, Rebecca Darlay, Yoshihiro Aiba, Yuki Hitomi

J Hepatol· September 2021

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Coronin-1 is phosphorylated at Thr-412 by protein kinase Cα in human phagocytic cells.
Teruaki Oku, Yutaka Kaneko, Rie Ishii, Yuki Hitomi, Makoto Tsuiji

Biochem Biophys Rep· September 2021

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Regional heritability mapping identifies several novel loci (STAT4, ULK4, and KCNH5) for primary biliary cholangitis in the Japanese population.
Olivier Gervais, Kazuko Ueno, Yosuke Kawai, Yuki Hitomi, Yoshihiro Aiba

Eur J Hum Genet· August 2021

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The ubiquinone synthesis pathway is a promising drug target for Chagas disease.
Takeshi Nara, Yukari Nakagawa, Keiko Tsuganezawa, Hitomi Yuki, Katsuhiko Sekimata

PLoS One· June 2021

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X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis.
Rosanna Asselta, Elvezia M Paraboschi, Alessio Gerussi, Heather J Cordell, George F Mells, Yuki Hitomi

Gastroenterology· June 2021

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Combined inhibition of XIAP and BCL2 drives maximal therapeutic efficacy in genetically diverse aggressive acute myeloid leukemia.
Mari Hashimoto, Yoriko Saito, Ryo Nakagawa, Ikuko Ogahara, Shinsuke Takagi, Hitomi Yuki, Naoyuki Uchida, Yukihide Momozawa

Nat Cancer· March 2021

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FMODB: The World's First Database of Quantum Mechanical Calculations for Biomacromolecules Based on the Fragment Molecular Orbital Method.
Daisuke Takaya, Chiduru Watanabe, Shunpei Nagase, Kikuko Kamisaka, Yoshio Okiyama, Hitomi Yuki, Noriyuki Kurita

J Chem Inf Model· February 2021

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Mapping of susceptible variants for cold medicine-related Stevens-Johnson syndrome by whole-genome resequencing.
Yosuke Kawai, Yuki Hitomi, Mayumi Ueta, Seik-Soon Khor, Ken Nakatani

NPJ Genom Med· February 2021

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rs1944919 on chromosome 11q23.1 and its effector genes COLCA1/COLCA2 confer susceptibility to primary biliary cholangitis.
Yuki Hitomi, Yoshihiro Aiba, Yosuke Kawai, Kaname Kojima, Kazuko Ueno

Sci Rep· February 2021

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