Publications by authors named "Hitoshi Sakaguchi"

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Technical success and initial clinical outcome of partial frozen elephant trunk in various aortic arch pathology.
Takeshi Shimamoto, Kenji Minatoya, Tatsuhiko Komiya, Nobuhisa Ohno, Nobushige Tamura, Hitoshi Sakaguchi

Indian J Thorac Cardiovasc Surg· November 2025

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SARS-CoV-2 evolution in the Omicron era.
Cornelius Roemer, Daniel J Sheward, Ryan Hisner, Federico Gueli, Hitoshi Sakaguchi

Nat Microbiol· November 2023

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Sensory irritation to methylparaben is caused by its low metabolism in the skin.
Rie Ninomiya, Takafumi Nishijima, Masahiro Aoshima, Hitoshi Sakaguchi, Yoshiki Tokura

J Dermatol· July 2023

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Evaluation of MTT reducers and strongly colored substances in the Short Time Exposure test method for assessing eye irritation potential.
Takayuki Abo, Yuuki Deguchi, Takuo Yuki, Yutaka Takahashi, Masaaki Miyazawa, Hitoshi Sakaguchi

J Toxicol Sci· June 2023

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Development of an oral mucosal irritation test using a three-dimensional human buccal oral mucosal model.
Seiya Aizawa, Hidenori Yoshida, Kazuhiko Umeshita, Shinichi Watanabe, Yutaka Takahashi, Hitoshi Sakaguchi

Toxicol In Vitro· March 2023

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Incorporating integrated testing strategy (ITSv1) defined approach into read-across (RAx) in predicting skin sensitization potency: ITSv1-based RAx.
Kanako Nakayama, Anne Zifle, Sabrina Fritz, Anne Fuchs, Hitoshi Sakaguchi

Regul Toxicol Pharmacol· March 2023

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Proteolytic activity accelerates the T17/T22 recall response to an epicutaneous protein allergen-induced T2 response.
Akira Ogasawara, Takuo Yuki, Asuka Katagiri, Yi-Ting Lai, Yutaka Takahashi, Hitoshi Sakaguchi

J Immunotoxicol· December 2022

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A step-by-step approach for assessing acute oral toxicity without animal testing for additives of quasi-drugs and cosmetic ingredients.
Hajime Kojima, Tokio Nakada, Akiko Yagami, Hiroaki Todo, Jihei Nishimura, Hitoshi Sakaguchi

Curr Res Toxicol· December 2022

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SARS-CoV-2 Delta-Omicron Recombinant Viruses, United States.
Kristine A Lacek, Benjamin L Rambo-Martin, Dhwani Batra, Xiao-Yu Zheng, Norman Hassell, Hitoshi Sakaguchi

Emerg Infect Dis· July 2022

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A Mathematical Approach Using Strat-M to Predict the Percutaneous Absorption of Chemicals under Finite Dose Conditions.
Ryoki Kunita, Takafumi Nishijima, Hiroaki Todo, Kenji Sugibayashi, Hitoshi Sakaguchi

Pharmaceutics· June 2022

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Hapten sensitization to vaginal mucosa induces less recruitment of dendritic cells accompanying TGF-β-expressing CD206 cells compared with skin.
Kanako Nakayama, Taku Nishijo, Masaaki Miyazawa, Tetsuro Watabe, Miyuki Azuma, Hitoshi Sakaguchi

Immun Inflamm Dis· April 2022

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Implementation of a dermal sensitization threshold (DST) concept for risk assessment: structure-based DST and data-based DST.
Taku Nishijo, Anne Marie Api, G Frank Gerberick, Masaaki Miyazawa, Mihwa Na, Hitoshi Sakaguchi

Crit Rev Toxicol· January 2022

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Epicutaneous challenge with protease allergen requires its protease activity to recall T2 and T17/T22 responses in mice pre-sensitized via distant skin.
Akira Ogasawara, Takuo Yuki, Toshiro Takai, Kyosuke Yokozeki, Asuka Katagiri, Hitoshi Sakaguchi

J Immunotoxicol· December 2021

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Total dose defines the incidence of percutaneous IgE/IgG1 mediated immediate-type hypersensitivity caused by papain.
Kyosuke Yokozeki, Takuo Yuki, Akira Ogasawara, Asuka Katagiri, Yutaka Takahashi, Hitoshi Sakaguchi

J Appl Toxicol· June 2021

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Characterization of dermal sensitization potential for industrial or agricultural chemicals with EpiSensA.
Hideyuki Mizumachi, Matthew J LeBaron, Raja S Settivari, Masaaki Miyazawa, Mary Sue Marty, Hitoshi Sakaguchi

J Appl Toxicol· June 2021

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Differential susceptibility between skin and vaginal mucosa in sensitization phase of allergic contact dermatitis in mice.
Taku Nishijo, Kanako Nakayama, Masaaki Miyazawa, Yasutaka Kuroda, Hitoshi Sakaguchi

Immun Inflamm Dis· December 2020

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Application of the dermal sensitization threshold concept to chemicals classified as high potency category for skin sensitization assessment of ingredients for consumer products.
Taku Nishijo, Anne Marie Api, G Frank Gerberick, Masaaki Miyazawa, David W Roberts, Hitoshi Sakaguchi

Regul Toxicol Pharmacol· November 2020

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An acid-hydrolyzed wheat protein activates the inflammatory and NF-κB pathways leading to long TSLP transcription in human keratinocytes.
Yasutaka Kuroda, Takuo Yuki, Yutaka Takahashi, Hitoshi Sakaguchi, Kayoko Matsunaga

J Toxicol Sci· September 2020

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Adjustment of a no expected sensitization induction level derived from Bayesian network integrated testing strategy for skin sensitization risk assessment.
Yuki Otsubo, Taku Nishijo, Hideyuki Mizumachi, Kazutoshi Saito, Masaaki Miyazawa, Hitoshi Sakaguchi

J Toxicol Sci· August 2020

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Improvement in the quality of life of patients with rhododendrol-induced leukoderma after camouflaging with dihydroxyacetone cream.
Kayoko Matsunaga, Minoru Sasaki, Takao Okajima, Masahiro Miyaki, Hitoshi Sakaguchi

J Dermatol· July 2020

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Sensitivity of KeratinoSens and h-CLAT for detecting minute amounts of sensitizers to evaluate botanical extract.
Taku Nishijo, Masaaki Miyazawa, Kazutoshi Saito, Yuki Otsubo, Hideyuki Mizumachi, Hitoshi Sakaguchi

J Toxicol Sci· January 2019

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The dermal sensitization threshold (DST) approach for mixtures evaluated as negative in in vitro test methods; mixture DST.
Taku Nishijo, Masaaki Miyazawa, Kazutoshi Saito, Yuki Otsubo, Hideyuki Mizumachi, Hitoshi Sakaguchi

J Toxicol Sci· January 2019

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Expansion of the applicability domain for highly volatile substances on the Short Time Exposure test method and the predictive performance in assessing eye irritation potential.
Takayuki Abo, Takuo Yuki, Rui Xu, Daisuke Araki, Yutaka Takahashi, Hitoshi Sakaguchi

J Toxicol Sci· August 2018

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Predictive performance and inter-laboratory reproducibility in assessing eye irritation potential of water- and oil-soluble mixtures using the Short Time Exposure test method.
Takayuki Abo, Allison Hilberer, Christine Behle-Wagner, Mika Watanabe, David Cameron, Hitoshi Sakaguchi

Toxicol In Vitro· April 2018

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A Case of Retinal Detachment with Unique Optical Coherence Tomography Findings after Gamma Knife® Radiosurgery Treatment for Choroidal Melanoma.
Daisaku Kimura, Teruyo Kida, Takaki Sato, Masanori Fukumoto, Ryohsuke Kohmoto, Hitoshi Sakaguchi

Case Rep Ophthalmol· January 2018

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