Publications by authors named "Hitoshi Tada"

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Pirfenidone encapsulated in succinylated gelatin-coated liposomes exhibits sustained antifibrotic effects in vitro models of renal, pulmonary, and hepatic fibrosis.
Kohei Togami, Yukimune Kanehira, Yuki Nakamura, Hirotsugu Ishii, Ryota Abe, Hitoshi Tada

J Pharm Sci· July 2025

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Sea ice records over more than a century at an observatory facing the Okhotsk coast of Hokkaido, Japan.
Takahiro Toyoda, Kento Tsukagawa, Yusuke Kimura, Honoka Abe, Meiji Honda, Hitoshi Tada

Sci Data· June 2025

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Treatment selection in the clinical practice of systemic lupus erythematosus: Results from the Kyushu Collagen Disease Network for Systemic Lupus Erythematosus (KCDN-SLE) registry.
Masahiro Ayano, Naoyasu Ueda, Koji Mishima, Shun-Ichiro Ota, Kazuo Kushimoto, Hitoshi Tada

Mod Rheumatol· December 2024

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Heterogenous Intrapulmonary Distribution of Aerosolized Model Compounds in Mice with Bleomycin-Induced Pulmonary Fibrosis.
Kohei Togami, Yukimune Kanehira, Yuki Yumita, Hiroaki Ozaki, Rui Wang, Hitoshi Tada

J Aerosol Med Pulm Drug Deliv· December 2023

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Development of visualization and analysis methods for evaluating intratumoral nanoparticle kinetics for tumor-targeted drug delivery using Förster resonance energy transfer in vivo live imaging and tissue clearing techniques.
Kohei Togami, Kiyomi Ishizawa, Mio Yasuda, Hitoshi Tada, Sumio Chono

J Pharm Biomed Anal· January 2023

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Improvement of the pharmacokinetics and antifibrotic effects of nintedanib by intrapulmonary administration of a nintedanib-hydroxypropyl-γ-cyclodextrin inclusion complex in mice with bleomycin-induced pulmonary fibrosis.
Kohei Togami, Arisa Ogasawara, Sayo Irie, Kenji Iwata, Kotaro Yamaguchi, Hitoshi Tada

Eur J Pharm Biopharm· March 2022

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Aerosolized Liposomal Formulation Prevents Enhanced Drug Transfer from Fibrotic Lungs to the Systemic Circulation.
Kohei Togami, Kaede Kurasho, Yukimune Kanehira, Hitoshi Tada, Sumio Chono

Curr Drug Deliv· December 2021

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Multiscale Live Imaging Using Förster Resonance Energy Transfer (FRET) for Evaluating the Biological Behavior of Nanoparticles as Drug Carriers.
Kiyomi Ishizawa, Kohei Togami, Hitoshi Tada, Sumio Chono

J Pharm Sci· December 2020

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Evaluation of tissue-clearing techniques for intraorgan imaging of distribution of polymeric nanoparticles as drug carriers.
Kiyomi Ishizawa, Kohei Togami, Hitoshi Tada, Sumio Chono

Drug Dev Ind Pharm· December 2020

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Three-Dimensional Imaging of Pulmonary Fibrotic Foci at the Alveolar Scale Using Tissue-Clearing Treatment with Staining Techniques of Extracellular Matrix.
Kohei Togami, Hiroaki Ozaki, Yuki Yumita, Anri Kitayama, Hitoshi Tada

Int J Biomed Imaging· December 2020

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Prolonged distribution of aerosolized PEGylated liposomes in the lungs of mice with bleomycin-induced pulmonary fibrosis.
Kohei Togami, Yuki Maruta, Mao Nanbu, Hitoshi Tada, Sumio Chono

Drug Dev Ind Pharm· November 2020

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Intratumoral delivery and therapeutic efficacy of nanoparticle-encapsulated anti-tumor siRNA following intrapulmonary administration for potential treatment of lung cancer.
Yukimune Kanehira, Kohei Togami, Kiyomi Ishizawa, Shingo Sato, Hitoshi Tada

Pharm Dev Technol· November 2019

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The Effect of Dexmedetomidine on Oral Mucosal Blood Flow and the Absorption of Lidocaine.
Shu Tomita, Shinya Yamazaki, Kohei Togami, Hitoshi Tada, Hiroyoshi Kawaai

Anesth Prog· October 2019

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Evaluation of various tissue-clearing techniques for the three-dimensional visualization of liposome distribution in mouse lungs at the alveolar scale.
Kohei Togami, Takayuki Daisho, Yuki Yumita, Anri Kitayama, Hitoshi Tada

Int J Pharm· May 2019

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Tissue-Clearing Techniques Enable Three-Dimensional Visualization of Aerosolized Model Compound and Lung Structure at the Alveolar Scale.
Kohei Togami, Anri Kitayama, Takayuki Daisho, Rui Wang, Hitoshi Tada

Biol Pharm Bull· August 2018

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Evaluation of permeability alteration and epithelial-mesenchymal transition induced by transforming growth factor-β in A549, NCI-H441, and Calu-3 cells: Development of an in vitro model of respiratory epithelial cells in idiopathic pulmonary fibrosis.
Kohei Togami, Kotaro Yamaguchi, Sumio Chono, Hitoshi Tada

J Pharmacol Toxicol Methods· July 2017

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Alteration in Intrapulmonary Pharmacokinetics of Aerosolized Model Compounds Due to Disruption of the Alveolar Epithelial Barriers Following Bleomycin-Induced Pulmonary Fibrosis in Rats.
Kohei Togami, Sumio Chono, Hitoshi Tada

J Pharm Sci· March 2016

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Efficient delivery to human lung fibroblasts (WI-38) of pirfenidone incorporated into liposomes modified with truncated basic fibroblast growth factor and its inhibitory effect on collagen synthesis in idiopathic pulmonary fibrosis.
Kohei Togami, Aki Miyao, Kei Miyakoshi, Yukimune Kanehira, Hitoshi Tada

Biol Pharm Bull· December 2015

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Pharmacokinetic evaluation of tissue distribution of pirfenidone and its metabolites for idiopathic pulmonary fibrosis therapy.
Kohei Togami, Yukimune Kanehira, Hitoshi Tada

Biopharm Drug Dispos· May 2015

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Lidocaine concentration in mandibular bone after subperiosteal infiltration anesthesia decreases with elevation of periosteal flap and irrigation with saline.
Sachie Ogawa, Masahiro Watanabe, Hiroyoshi Kawaai, Hitoshi Tada, Shinya Yamazaki

Anesth Prog· September 2014

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Possible involvement of pirfenidone metabolites in the antifibrotic action of a therapy for idiopathic pulmonary fibrosis.
Kohei Togami, Yukimune Kanehira, Hitoshi Tada

Biol Pharm Bull· April 2014

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Dexmedetomidine decreases the oral mucosal blood flow.
Hiroyoshi Kawaai, Kenji Yoshida, Eri Tanaka, Kohei Togami, Hitoshi Tada

Br J Oral Maxillofac Surg· December 2013

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Enantioselective uptake of fexofenadine by Caco-2 cells as model intestinal epithelial cells.
Kohei Togami, Yuka Tosaki, Sumio Chono, Kazuhiro Morimoto, Masataka Hayasaka, Hitoshi Tada

J Pharm Pharmacol· January 2013

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[Meta-analysis-based examination regarding the efficacy of angiotensin II receptor blockers and calcium channel blockers in borderline diabetes and diabetes patients].
Junichi Mukai, Hitoshi Tada, Masatomo Miura, Kiminori Mohri

Yakugaku Zasshi· February 2012

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[Analysis of medical accident cases and current status of medical care for the elderly at a mixed-care hospital].
Satoshi Terai, Hitoshi Tada

Nihon Ronen Igakkai Zasshi· July 2011

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