Publications by authors named "Sumio Chono"

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Pirfenidone encapsulated in succinylated gelatin-coated liposomes exhibits sustained antifibrotic effects in vitro models of renal, pulmonary, and hepatic fibrosis.
Kohei Togami, Yukimune Kanehira, Yuki Nakamura, Hirotsugu Ishii, Ryota Abe, Sumio Chono

J Pharm Sci· July 2025

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Type IV Collagen-Targeting Nanoparticles for Efficient Delivery to the Renal Interstitium in Fibrotic Kidneys.
Yuki Nakamura, Kohei Togami, Sumio Chono

Curr Drug Deliv· May 2025

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Renal Interstitial Distribution of Full-Length IgG and Fab Fragments in Unilateral Ureteral Obstruction-Induced Fibrotic Kidneys.
Yuki Nakamura, Kohei Togami, Sumio Chono

Biopharm Drug Dispos· April 2025

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Heterogenous Intrapulmonary Distribution of Aerosolized Model Compounds in Mice with Bleomycin-Induced Pulmonary Fibrosis.
Kohei Togami, Yukimune Kanehira, Yuki Yumita, Hiroaki Ozaki, Rui Wang, Sumio Chono

J Aerosol Med Pulm Drug Deliv· December 2023

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Development of a Compensated Förster Resonance Energy Transfer Imaging for Improved Assessment of the Intrapulmonary Distribution of Polymeric Nanoparticles.
Kohei Togami, Yoshiki Hazama, Yuki Nakamura, Kiyomi Ishizawa, Sumio Chono

J Pharm Sci· October 2023

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Development of visualization and analysis methods for evaluating intratumoral nanoparticle kinetics for tumor-targeted drug delivery using Förster resonance energy transfer in vivo live imaging and tissue clearing techniques.
Kohei Togami, Kiyomi Ishizawa, Mio Yasuda, Hitoshi Tada, Sumio Chono

J Pharm Biomed Anal· January 2023

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Improvement of the pharmacokinetics and antifibrotic effects of nintedanib by intrapulmonary administration of a nintedanib-hydroxypropyl-γ-cyclodextrin inclusion complex in mice with bleomycin-induced pulmonary fibrosis.
Kohei Togami, Arisa Ogasawara, Sayo Irie, Kenji Iwata, Kotaro Yamaguchi, Sumio Chono

Eur J Pharm Biopharm· March 2022

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Aerosolized Liposomal Formulation Prevents Enhanced Drug Transfer from Fibrotic Lungs to the Systemic Circulation.
Kohei Togami, Kaede Kurasho, Yukimune Kanehira, Hitoshi Tada, Sumio Chono

Curr Drug Deliv· December 2021

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Multiscale Live Imaging Using Förster Resonance Energy Transfer (FRET) for Evaluating the Biological Behavior of Nanoparticles as Drug Carriers.
Kiyomi Ishizawa, Kohei Togami, Hitoshi Tada, Sumio Chono

J Pharm Sci· December 2020

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Evaluation of tissue-clearing techniques for intraorgan imaging of distribution of polymeric nanoparticles as drug carriers.
Kiyomi Ishizawa, Kohei Togami, Hitoshi Tada, Sumio Chono

Drug Dev Ind Pharm· December 2020

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Three-Dimensional Imaging of Pulmonary Fibrotic Foci at the Alveolar Scale Using Tissue-Clearing Treatment with Staining Techniques of Extracellular Matrix.
Kohei Togami, Hiroaki Ozaki, Yuki Yumita, Anri Kitayama, Hitoshi Tada, Sumio Chono

Int J Biomed Imaging· December 2020

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Prolonged distribution of aerosolized PEGylated liposomes in the lungs of mice with bleomycin-induced pulmonary fibrosis.
Kohei Togami, Yuki Maruta, Mao Nanbu, Hitoshi Tada, Sumio Chono

Drug Dev Ind Pharm· November 2020

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Intratumoral delivery and therapeutic efficacy of nanoparticle-encapsulated anti-tumor siRNA following intrapulmonary administration for potential treatment of lung cancer.
Yukimune Kanehira, Kohei Togami, Kiyomi Ishizawa, Shingo Sato, Hitoshi Tada, Sumio Chono

Pharm Dev Technol· November 2019

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Evaluation of various tissue-clearing techniques for the three-dimensional visualization of liposome distribution in mouse lungs at the alveolar scale.
Kohei Togami, Takayuki Daisho, Yuki Yumita, Anri Kitayama, Hitoshi Tada, Sumio Chono

Int J Pharm· May 2019

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Tissue-Clearing Techniques Enable Three-Dimensional Visualization of Aerosolized Model Compound and Lung Structure at the Alveolar Scale.
Kohei Togami, Anri Kitayama, Takayuki Daisho, Rui Wang, Hitoshi Tada, Sumio Chono

Biol Pharm Bull· August 2018

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Aerosolized liposomes with dipalmitoyl phosphatidylcholine enhance pulmonary absorption of encapsulated insulin compared with co-administered insulin.
Sumio Chono, Kohei Togami, Shirou Itagaki

Drug Dev Ind Pharm· November 2017

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Evaluation of permeability alteration and epithelial-mesenchymal transition induced by transforming growth factor-β in A549, NCI-H441, and Calu-3 cells: Development of an in vitro model of respiratory epithelial cells in idiopathic pulmonary fibrosis.
Kohei Togami, Kotaro Yamaguchi, Sumio Chono, Hitoshi Tada

J Pharmacol Toxicol Methods· July 2017

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Ingestibility and Formulation Quality of Lansoprazole Orally Disintegrating Tablets.
Sumio Chono, Megumi Matsui, Katsuki Nakamura, Ryoya Kasai

J Pharm (Cairo)· December 2016

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Sustained distribution of aerosolized PEGylated liposomes in epithelial lining fluids on alveolar surfaces.
Keita Kaneko, Kohei Togami, Eri Yamamoto, Shujun Wang, Kazuhiro Morimoto, Sumio Chono

Drug Deliv Transl Res· October 2016

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Alteration in Intrapulmonary Pharmacokinetics of Aerosolized Model Compounds Due to Disruption of the Alveolar Epithelial Barriers Following Bleomycin-Induced Pulmonary Fibrosis in Rats.
Kohei Togami, Sumio Chono, Hitoshi Tada

J Pharm Sci· March 2016

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Efficient delivery to human lung fibroblasts (WI-38) of pirfenidone incorporated into liposomes modified with truncated basic fibroblast growth factor and its inhibitory effect on collagen synthesis in idiopathic pulmonary fibrosis.
Kohei Togami, Aki Miyao, Kei Miyakoshi, Yukimune Kanehira, Hitoshi Tada, Sumio Chono

Biol Pharm Bull· December 2015

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Involvement of intestinal permeability in the oral absorption of clarithromycin and telithromycin.
Kohei Togami, Yoshiaki Hayashi, Sumio Chono, Kazuhiro Morimoto

Biopharm Drug Dispos· September 2014

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Subcellular distribution of azithromycin and clarithromycin in rat alveolar macrophages (NR8383) in vitro.
Kohei Togami, Sumio Chono, Kazuhiro Morimoto

Biol Pharm Bull· April 2014

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Aerosol-based efficient delivery of azithromycin to alveolar macrophages for treatment of respiratory infections.
Kohei Togami, Sumio Chono, Kazuhiro Morimoto

Pharm Dev Technol· March 2014

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Enantioselective uptake of fexofenadine by Caco-2 cells as model intestinal epithelial cells.
Kohei Togami, Yuka Tosaki, Sumio Chono, Kazuhiro Morimoto, Masataka Hayasaka

J Pharm Pharmacol· January 2013

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