Publications by authors named "Holly Clouse"

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Improved translation of Na1.5 channel inhibition to in vivo QRS interval prolongation via the hIPSC cardiomyocyte model.
John P Imredy, Holly Clouse, Mei Zhang, Spencer Dech, Qiuwei Xu

J Pharmacol Toxicol Methods· September 2025

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High content imaging of relative ATP levels for mitochondrial toxicity prediction in human induced pluripotent stem cell derived cardiomyocytes.
John Bassett, Bharathi Balasubramanian, Holly Clouse, Elena Trepakova

Toxicology· June 2025

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Comparative assessment of Ca oscillations in 2- and 3-dimensional hiPSC derived and isolated cortical neuronal networks.
John P Imredy, Gautier Roussignol, Holly Clouse, Giorgia Salvagiotto, Ludmilla Mazelin-Winum

J Pharmacol Toxicol Methods· November 2023

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Assessing Drug-Induced Long QT and Proarrhythmic Risk Using Human Stem-Cell-Derived Cardiomyocytes in a Ca2+ Imaging Assay: Evaluation of 28 CiPA Compounds at Three Test Sites.
Hua Rong Lu, Haoyu Zeng, Ralf Kettenhofen, Liang Guo, Ivan Kopljar, Holly Clouse

Toxicol Sci· August 2019

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HiPSC-CMs from different sex and ethnic origin donors exhibit qualitatively different responses to several classes of pharmacological challenges.
Haoyu Zeng, Jixin Wang, Holly Clouse, Armando Lagrutta, Frederick Sannajust

J Pharmacol Toxicol Methods· June 2019

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Human-induced pluripotent stem cell-derived cardiomyocytes have limited I for repolarization reserve as revealed by specific KCNQ1/KCNE1 blocker.
Haoyu Zeng, Jixin Wang, Holly Clouse, Armando Lagrutta, Frederick Sannajust

JRSM Cardiovasc Dis· June 2019

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Resolving the Reversed Rate Effect of Calcium Channel Blockers on Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes and the Impact on In Vitro Cardiac Safety Evaluation.
Haoyu Zeng, Jixin Wang, Holly Clouse, Armando Lagrutta, Frederick Sannajust

Toxicol Sci· February 2019

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Urinary biomarkers trefoil factor 3 and albumin enable early detection of kidney tubular injury.
Yan Yu, Hong Jin, Daniel Holder, Josef S Ozer, Stephanie Villarreal, Holly Clouse

Nat Biotechnol· May 2010

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A panel of urinary biomarkers to monitor reversibility of renal injury and a serum marker with improved potential to assess renal function.
Josef S Ozer, Frank Dieterle, Sean Troth, Elias Perentes, André Cordier, Holly K Clouse

Nat Biotechnol· May 2010

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