Publications by authors named "Hossameldin A Aziz"

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Design, Synthesis, and Mechanistic Study of Novel Ciprofloxacin/Thiazole Chalcone Hybrids as Potential Anticancer Agents.
Hamada Hashem, Ali M Elshamsy, Safwat M Rabea, Adel A Marzouk, Stefan Bräse, Hossameldin A Aziz

Pharmaceuticals (Basel)· November 2025

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Design, Synthesis, In Silico Docking, Multitarget Bioevaluation and Molecular Dynamic Simulation of Novel Pyrazolo[3,4-]Pyrimidinone Derivatives as Potential In Vitro and In Vivo Anti-Inflammatory Agents.
Mostafa Roshdi, Mamdouh F A Mohamed, Eman A M Beshr, Hossameldin A Aziz, Sahar M Gebril

Pharmaceuticals (Basel)· September 2025

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Design, Synthesis, and Studies of New Norfloxacin Analogues with Broad Spectrum Antibacterial Activity Topoisomerase II Inhibition.
Ahmed M El-Saghier, Laila Abosella, Abdelfattah Hassan, Esmail O Elakesh, Stefan Bräse, Hossameldin A Aziz

Pharmaceuticals (Basel)· April 2025

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Design, Synthesis, Anticancer Screening, and Mechanistic Study of Spiro-N-(4-sulfamoyl-phenyl)-1,3,4-thiadiazole-2-carboxamide Derivatives.
Ahmed M El-Saghier, Hamada Hashem, Sherif A Maher, Souhaila S Enaili, Abdullah Alkhammash, Hossameldin A Aziz

Int J Mol Sci· January 2025

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Unveiling the Anticancer Potential of a New Ciprofloxacin-Chalcone Hybrid as an Inhibitor of Topoisomerases I & II and Apoptotic Inducer.
Doaa Mohamed Elroby Ali, Hossameldin A Aziz, Stefan Bräse, Areej Al Bahir, Abdullah Alkhammash

Molecules· November 2024

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Design, synthesis and mechanistic study of N-4-Piperazinyl Butyryl Thiazolidinedione derivatives of ciprofloxacin with Anticancer Activity via Topoisomerase I/II inhibition.
Hossameldin A Aziz, Ahmed M El-Saghier, Mohamed Badr, Bakheet E M Elsadek, Gamal El-Din A Abuo-Rahma

Sci Rep· October 2024

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Synthesis, Physicochemical Characterization using a Facile Validated HPLC Quantitation Analysis Method of 4-Chloro-phenylcarbamoyl-methyl Ciprofloxacin and Its Biological Investigations.
Mostafa F Al-Hakkani, Nourhan Ahmed, Alaa A Abbas, Mohammad H A Hassan, Hossameldin A Aziz

Int J Mol Sci· October 2023

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Thiazolidine-2,4-dione-linked ciprofloxacin derivatives with broad-spectrum antibacterial, MRSA and topoisomerase inhibitory activities.
Hossameldin A Aziz, Ahmed M M El-Saghier, Mohamed Badr, Gamal El-Din A Abuo-Rahma, Mai E Shoman

Mol Divers· June 2022

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Synthesis and antimicrobial evaluation of new nitric oxide-donating fluoroquinolone/oxime hybrids.
Hossameldin A Aziz, Gamal A I Moustafa, Gamal El-Din A Abuo-Rahma, Safwat M Rabea, Glenn Hauk

Arch Pharm (Weinheim)· January 2021

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