Publications by authors named "Howard Clark"

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Knock-out mouse models and single particle ICP-MS reveal that SP-D and SP-A deficiency reduces agglomeration of inhaled gold nanoparticles in vivo without significant changes to overall lung clearance.
Adam Laycock, Artur Kirjakulov, Matthew Darren Wright, Konstantinos Nikolaos Bourdakos, Sumeet Mahajan, Howard Clark

Nanotoxicology· February 2025

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Surfactant Protein-A and its immunomodulatory roles in infant respiratory syncytial virus infection: a potential for therapeutic intervention?
Muhammad Pradhika Mapindra, Tania Castillo-Hernandez, Howard Clark, Jens Madsen

Am J Physiol Lung Cell Mol Physiol· January 2025

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Towards quantifying biomarkers for respiratory distress in preterm infants: Machine learning on mid infrared spectroscopy of lipid mixtures.
Waseem Ahmed, Aneesh Vincent Veluthandath, Jens Madsen, Howard W Clark, Ahilanandan Dushianthan

Talanta· August 2024

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Recombinant fragment of human surfactant protein D to prevent neonatal chronic lung disease (RESPONSE): a protocol for a phase I safety trial in a tertiary neonatal unit.
Reena Bhatt, Jens Madsen, Tania Castillo-Hernandez, Kathy Chant, Hakim-Moulay Dehbi, Howard Clark

BMJ Open· August 2024

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Mass spectrometry imaging of phosphatidylcholine metabolism in lungs administered with therapeutic surfactants and isotopic tracers.
Shane R Ellis, Emily Hall, Madhuriben Panchal, Bryn Flinders, Jens Madsen, Howard W Clark

J Lipid Res· July 2024

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Functional Characterisation of Surfactant Protein A as a Novel Prophylactic Means against Oncogenic HPV Infections.
Sinead Carse, Tim Reid, Jens Madsen, Howard Clark, Artur Kirjakulov

Int J Mol Sci· July 2024

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Respiratory Syncytial Virus Maternal Vaccination in Infants below 6 Months of Age: Meta-Analysis of Safety, Immunogenicity, and Efficacy.
Muhammad Pradhika Mapindra, Muhammad Pradhiki Mahindra, Paul McNamara, Malcolm G Semple, Howard Clark

Neonatology· June 2024

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A randomized controlled trial of nebulized surfactant for the treatment of severe COVID-19 in adults (COVSurf trial).
Ahilanandan Dushianthan, Howard W Clark, David Brealey, Danny Pratt, James B Fink

Sci Rep· November 2023

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Success of blinding a procedural intervention in a randomised controlled trial in preterm infants receiving respiratory support.
Elizabeth Reid, Omar F Kamlin, Francesca Orsini, Antonio G De Paoli, Howard W Clark

Clin Trials· October 2023

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Two-Year Outcomes After Minimally Invasive Surfactant Therapy in Preterm Infants: Follow-Up of the OPTIMIST-A Randomized Clinical Trial.
Peter A Dargaville, C Omar F Kamlin, Francesca Orsini, Xiaofang Wang, Antonio G De Paoli, Howard W Clark

JAMA· September 2023

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Multiomics links global surfactant dysregulation with airflow obstruction and emphysema in COPD.
Ventzislava A Hristova, Alastair Watson, Raghothama Chaerkady, Matthew S Glover, Jodie Ackland, Howard W Clark

ERJ Open Res· May 2023

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Rapid Phospholipid Turnover after Surfactant Nebulization in Severe COVID-19 Infection: A Randomized Clinical Trial.
Anthony D Postle, Howard W Clark, Jim Fink, Jens Madsen, Grielof Koster

Am J Respir Crit Care Med· February 2022

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Prediction of Neonatal Respiratory Distress Biomarker Concentration by Application of Machine Learning to Mid-Infrared Spectra.
Waseem Ahmed, Aneesh Vincent Veluthandath, David J Rowe, Jens Madsen, Howard W Clark

Sensors (Basel)· February 2022

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Effect of Minimally Invasive Surfactant Therapy vs Sham Treatment on Death or Bronchopulmonary Dysplasia in Preterm Infants With Respiratory Distress Syndrome: The OPTIMIST-A Randomized Clinical Trial.
Peter A Dargaville, C Omar F Kamlin, Francesca Orsini, Xiaofang Wang, Antonio G De Paoli, Howard W Clark

JAMA· December 2021

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Exogenous pulmonary surfactant in COVID-19 ARDS. The similarities to neonatal RDS suggest a new scenario for an 'old' strategy.
Reena M Bhatt, Howard W Clark, Massimo Girardis, Stefano Busani

BMJ Open Respir Res· September 2021

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SP-A and SP-D: Dual Functioning Immune Molecules With Antiviral and Immunomodulatory Properties.
Alastair Watson, Jens Madsen, Howard William Clark

Front Immunol· February 2021

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Postnatal adaptations of phosphatidylcholine metabolism in extremely preterm infants: implications for choline and PUFA metabolism.
Kevin C W Goss, Victoria M Goss, J Paul Townsend, Grielof Koster, Howard W Clark

Am J Clin Nutr· December 2020

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Nebulised surfactant for the treatment of severe COVID-19 in adults (COV-Surf): A structured summary of a study protocol for a randomized controlled trial.
Ahilanandan Dushianthan, Howard Clark, Jens Madsen, Robin Mogg, Lewis Matthews

Trials· December 2020

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Generation of novel trimeric fragments of human SP-A and SP-D after recombinant soluble expression in E. coli.
Alastair Watson, Grith L Sørensen, Uffe Holmskov, Harry J Whitwell, Jens Madsen, Howard Clark

Immunobiology· July 2020

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Surfactant Proteins A and D: Trimerized Innate Immunity Proteins with an Affinity for Viral Fusion Proteins.
Alastair Watson, Maximillian J S Phipps, Howard W Clark, Chris-Kriton Skylaris, Jens Madsen

J Innate Immun· February 2020

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Surfactant Protein A Impairs Genital HPV16 Pseudovirus Infection by Innate Immune Cell Activation in A Murine Model.
Sylvia Ujma, Sinead Carse, Alisha Chetty, William Horsnell, Howard Clark

Pathogens· December 2019

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Surfactant Protein D Deficiency Aggravates Cigarette Smoke-Induced Lung Inflammation by Upregulation of Ceramide Synthesis.
Bartosz Pilecki, Helle Wulf-Johansson, Christian Støttrup, Patricia Troest Jørgensen, Pascal Djiadeu, Howard William Clark

Front Immunol· November 2019

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Increased surfactant protein-D levels in the airways of preterm neonates with sepsis indicated responses to infectious challenges.
Rose-Marie A Mackay, J Paul Townsend, Jennifer Calvert, Mark Anthony, Andrew R Wilkinson, Howard W Clark

Acta Paediatr· May 2019

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The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation.
Freya R Svedberg, Sheila L Brown, Maria Z Krauss, Laura Campbell, Catherine Sharpe, Howard Clark

Nat Immunol· May 2019

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Metabolism of a synthetic compared with a natural therapeutic pulmonary surfactant in adult mice.
Jens Madsen, Madhuriben H Panchal, Rose-Marie A Mackay, Mercedes Echaide, Grielof Koster, Howard W Clark

J Lipid Res· October 2018

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