Publications by authors named "Hubert C Chen"

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Multi-omic analysis of canine aging uncovers conserved aging pathways.
Zane Koch, Jessica L Graves, Steve Annan, Phillip A Frankino, Michelle Nelson, Hubert C Chen

Geroscience· December 2025

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Safety and immunogenicity of Px563L, a recombinant anthrax vaccine candidate, in a two-dose regimen for post-exposure prophylaxis in healthy adults.
Jane C Schneider, Hubert C Chen, Edgar Bautista, Diane Retallack

Vaccine· October 2021

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Week 4 Liver Fat Reduction on MRI as an Early Predictor of Treatment Response in Participants with Nonalcoholic Steatohepatitis.
Hanyu Jiang, Hubert C Chen, Kyle J Lafata, Mustafa R Bashir

Radiology· August 2021

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A structurally optimized FXR agonist, MET409, reduced liver fat content over 12 weeks in patients with non-alcoholic steatohepatitis.
Stephen A Harrison, Mustafa R Bashir, Kyoung-Jin Lee, Jennifer Shim-Lopez, Jonathan Lee, Hubert C Chen

J Hepatol· July 2021

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Role of islet-, gut-, and adipocyte-derived hormones in the central control of food intake and body weight: implications for an integrated neurohormonal approach to obesity pharmacotherapy.
Hubert C Chen, Jonathan D Roth, Brock E Schroeder, Christian Weyer

Curr Diabetes Rev· May 2008

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Enhancing energy and glucose metabolism by disrupting triglyceride synthesis: Lessons from mice lacking DGAT1.
Hubert C Chen

Nutr Metab (Lond)· January 2006

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Inhibition of triglyceride synthesis as a treatment strategy for obesity: lessons from DGAT1-deficient mice.
Hubert C Chen, Robert V Farese

Arterioscler Thromb Vasc Biol· March 2005

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Insulin-induced activation of atypical protein kinase C, but not protein kinase B, is maintained in diabetic (ob/ob and Goto-Kakazaki) liver. Contrasting insulin signaling patterns in liver versus muscle define phenotypes of type 2 diabetic and high fat-induced insulin-resistant states.
Mary L Standaert, Mini P Sajan, Atsushi Miura, Yoshinori Kanoh, Hubert C Chen

J Biol Chem· June 2004

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Role of adipocyte-derived factors in enhancing insulin signaling in skeletal muscle and white adipose tissue of mice lacking Acyl CoA:diacylglycerol acyltransferase 1.
Hubert C Chen, Meghana Rao, Mini P Sajan, Mary Standaert, Yoshinori Kanoh

Diabetes· June 2004

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Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:diacylglycerol acyltransferase 1.
Hubert C Chen, Dalan R Jensen, Heather M Myers, Robert H Eckel, Robert V Farese

J Clin Invest· June 2003

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Analysis of energy expenditure at different ambient temperatures in mice lacking DGAT1.
Hubert C Chen, Zuleika Ladha, Steven J Smith, Robert V Farese

Am J Physiol Endocrinol Metab· January 2003

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Dissociation of obesity and impaired glucose disposal in mice overexpressing acyl coenzyme a:diacylglycerol acyltransferase 1 in white adipose tissue.
Hubert C Chen, Scot J Stone, Ping Zhou, Kimberly K Buhman, Robert V Farese

Diabetes· November 2002

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Deficiency of acyl coenzyme a:diacylglycerol acyltransferase 1 increases leptin sensitivity in murine obesity models.
Hubert C Chen, Zuleika Ladha, Robert V Farese

Endocrinology· August 2002

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Fatty acids, triglycerides, and glucose metabolism: recent insights from knockout mice.
Hubert C Chen, Robert V Farese

Curr Opin Clin Nutr Metab Care· July 2002

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Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stimulated glucose transport.
Hubert C Chen, Gautam Bandyopadhyay, Mini P Sajan, Yoshinori Kanoh, Mary Standaert

J Biol Chem· June 2002

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Determination of adipocyte size by computer image analysis.
Hubert C Chen, Robert V Farese

J Lipid Res· June 2002

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Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1.
Hubert C Chen, Steven J Smith, Zuleika Ladha, Dalan R Jensen, Luis D Ferreira

J Clin Invest· April 2002

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Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands.
Hubert C Chen, Steven J Smith, Bryan Tow, Peter M Elias, Robert V Farese

J Clin Invest· January 2002

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