Publications by authors named "Hugh Barton"

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Predicting nonlinear relationships between external and internal concentrations with physiologically based pharmacokinetic modeling.
Daniel Hoer, Hugh A Barton, Alicia Paini, Michael Bartels, Brandall Ingle

Toxicol Appl Pharmacol· April 2022

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Opportunities and challenges related to saturation of toxicokinetic processes: Implications for risk assessment.
Yu-Mei Tan, Hugh A Barton, Alan Boobis, Rachel Brunner, Harvey Clewell

Regul Toxicol Pharmacol· December 2021

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Moving beyond Binary Predictions of Human Drug-Induced Liver Injury (DILI) toward Contrasting Relative Risk Potential.
Michael D Aleo, Falgun Shah, Scott Allen, Hugh A Barton, Chester Costales

Chem Res Toxicol· January 2020

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Quantitative systems toxicology (QST) reproduces species differences in PF-04895162 liver safety due to combined mitochondrial and bile acid toxicity.
Grant Generaux, Vinal V Lakhani, Yuching Yang, Sashi Nadanaciva, Luping Qiu, Hugh A Barton

Pharmacol Res Perspect· December 2019

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A Physiologically-Based Pharmacokinetic Model for the Prediction of Monoclonal Antibody Pharmacokinetics From In Vitro Data.
Hannah M Jones, Zhiwei Zhang, Paul Jasper, Haobin Luo, Lindsay B Avery, Hugh A Barton

CPT Pharmacometrics Syst Pharmacol· October 2019

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Explaining Ethnic Variability of Transporter Substrate Pharmacokinetics in Healthy Asian and Caucasian Subjects with Allele Frequencies of OATP1B1 and BCRP: A Mechanistic Modeling Analysis.
Rui Li, Hugh A Barton

Clin Pharmacokinet· April 2018

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Does the Systemic Plasma Profile Inform the Liver Profile? Analysis Using a Physiologically Based Pharmacokinetic Model and Individual Compounds.
Rui Li, Tristan S Maurer, Kevin Sweeney, Hugh A Barton

AAPS J· May 2016

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Erratum to: Translational Modeling in Schizophrenia: Predicting Human Dopamine D₂ Receptor Occupancy.
Martin Johnson, Magdalena Kozielska, Venkatesh Pilla Reddy, An Vermeulen, Hugh A Barton

Pharm Res· May 2016

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Translational Modeling in Schizophrenia: Predicting Human Dopamine D2 Receptor Occupancy.
Martin Johnson, Magdalena Kozielska, Venkatesh Pilla Reddy, An Vermeulen, Hugh A Barton

Pharm Res· April 2016

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Setting Clinical Exposure Levels of Concern for Drug-Induced Liver Injury (DILI) Using Mechanistic in vitro Assays.
Falgun Shah, Louis Leung, Hugh A Barton, Yvonne Will, A David Rodrigues

Toxicol Sci· October 2015

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Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury.
Jeffrey L Woodhead, Kyunghee Yang, Scott Q Siler, Paul B Watkins, Kim L R Brouwer, Hugh A Barton

Front Pharmacol· November 2014

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Dopamine D2 receptor occupancy as a predictor of catalepsy in rats: a pharmacokinetic-pharmacodynamic modeling approach.
Martin Johnson, Magdalena Kozielska, Venkatesh Pilla Reddy, An Vermeulen, Hugh A Barton

Pharm Res· October 2014

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Physiologically based pharmacokinetic prediction of telmisartan in human.
Rui Li, Avijit Ghosh, Tristan S Maurer, Emi Kimoto, Hugh A Barton

Drug Metab Dispos· October 2014

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Prediction of pharmacokinetics and drug-drug interactions when hepatic transporters are involved.
Rui Li, Hugh A Barton, Manthena V Varma

Clin Pharmacokinet· August 2014

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A "middle-out" approach to human pharmacokinetic predictions for OATP substrates using physiologically-based pharmacokinetic modeling.
Rui Li, Hugh A Barton, Phillip D Yates, Avijit Ghosh, Angela C Wolford

J Pharmacokinet Pharmacodyn· June 2014

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Cerebrospinal fluid β-Amyloid turnover in the mouse, dog, monkey and human evaluated by systematic quantitative analyses.
Yasong Lu, Hugh A Barton, Louis Leung, Liming Zhang, Eva Hajos-Korcsok

Neurodegener Dis· January 2014

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Urban planning for healthy cities. A review of the progress of the European Healthy Cities Programme.
Hugh Barton, Marcus Grant

J Urban Health· October 2013

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On translation of antibody drug conjugates efficacy from mouse experimental tumors to the clinic: a PK/PD approach.
Nahor Haddish-Berhane, Dhaval K Shah, Dangshe Ma, Mauricio Leal, Hans-Peter Gerber, Hugh A Barton

J Pharmacokinet Pharmacodyn· October 2013

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Case study illustrating the WHO IPCS guidance on characterization and application of physiologically based pharmacokinetic models in risk assessment.
M E Bette Meek, Hugh A Barton, Jos G Bessems, John C Lipscomb, Kannan Krishnan

Regul Toxicol Pharmacol· June 2013

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A multiscale, mechanism-driven, dynamic model for the effects of 5α-reductase inhibition on prostate maintenance.
Michael G Zager, Hugh A Barton

PLoS One· May 2013

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Model-based approaches to predict drug-drug interactions associated with hepatic uptake transporters: preclinical, clinical and beyond.
Hugh A Barton, Yurong Lai, Theunis C Goosen, Hannah M Jones, Ayman F El-Kattan

Expert Opin Drug Metab Toxicol· April 2013

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In vitro evaluation of hepatic transporter-mediated clinical drug-drug interactions: hepatocyte model optimization and retrospective investigation.
Yi-An Bi, Emi Kimoto, Samantha Sevidal, Hannah M Jones, Hugh A Barton

Drug Metab Dispos· June 2012

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Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data.
Hannah M Jones, Hugh A Barton, Yurong Lai, Yi-An Bi, Emi Kimoto

Drug Metab Dispos· May 2012

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The evolution of the OATP hepatic uptake transport protein family in DMPK sciences: from obscure liver transporters to key determinants of hepatobiliary clearance.
Katherine S Fenner, Hannah M Jones, Mohammed Ullah, Sarah Kempshall, Maurice Dickins, Hugh A Barton

Xenobiotica· January 2012

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The effectiveness of health appraisal processes currently in addressing health and wellbeing during spatial plan appraisal: a systematic review.
Selena Gray, Laurence Carmichael, Hugh Barton, Julie Mytton, Helen Lease

BMC Public Health· November 2011

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