Publications by authors named "Michael D Aleo"

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AI/ML Models to Predict the Severity of Drug-Induced Liver Injury for Small Molecules.
Mohan Rao, Vahid Nassiri, Cristóbal Alhambra, Jan Snoeys, Freddy Van Goethem, Michael D Aleo

Chem Res Toxicol· July 2023

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Hepatotoxicity reports in the FDA adverse event reporting system database: A comparison of drugs that cause injury mitochondrial or other mechanisms.
Payal Rana, Michael D Aleo, Xuerong Wen, Stephen Kogut

Acta Pharm Sin B· December 2021

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An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury.
Shingo Oda, Yuka Uchida, Michael D Aleo, Petra H Koza-Taylor, Yusuke Matsui

Arch Toxicol· January 2021

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Most Influential Physicochemical and In Vitro Assay Descriptors for Hepatotoxicity and Nephrotoxicity Prediction.
Payal Rana, Stephen Kogut, Xuerong Wen, Fatemeh Akhlaghi, Michael D Aleo

Chem Res Toxicol· July 2020

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Moving beyond Binary Predictions of Human Drug-Induced Liver Injury (DILI) toward Contrasting Relative Risk Potential.
Michael D Aleo, Falgun Shah, Scott Allen, Hugh A Barton, Chester Costales

Chem Res Toxicol· January 2020

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A Novel Lipidomics-Based Approach to Evaluating the Risk of Clinical Hepatotoxicity Potential of Drugs in 3D Human Microtissues.
Laura Goracci, Aurora Valeri, Simone Sciabola, Michael D Aleo, Wolfgang Moritz

Chem Res Toxicol· January 2020

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Quantitative systems toxicology (QST) reproduces species differences in PF-04895162 liver safety due to combined mitochondrial and bile acid toxicity.
Grant Generaux, Vinal V Lakhani, Yuching Yang, Sashi Nadanaciva, Luping Qiu, Michael D Aleo

Pharmacol Res Perspect· December 2019

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Lens cholesterol biosynthesis inhibition: A common mechanism of cataract formation in laboratory animals by pharmaceutical products.
Michael D Aleo, Colleen M Doshna, Daniel Baltrukonis, Jay H Fortner, Cynthia A Drupa

J Appl Toxicol· September 2019

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Liver safety evaluation of endothelin receptor antagonists using HepatoPac : A single model impact assessment on hepatocellular health, function and bile acid disposition.
Michael D Aleo, Okechukwu Ukairo, Amanda Moore, Onyi Irrechukwu, David M Potter

J Appl Toxicol· August 2019

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Phase I study of PF‐04895162, a Kv7 channel opener, reveals unexpected hepatotoxicity in healthy subjects, but not rats or monkeys: clinical evidence of disrupted bile acid homeostasis.
Michael D Aleo, Jiri Aubrecht, Paul D Bonin, Deborah A Burt, Jennifer Colangelo

Pharmacol Res Perspect· February 2019

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Evaluation of in Vitro Mitochondrial Toxicity Assays and Physicochemical Properties for Prediction of Organ Toxicity Using 228 Pharmaceutical Drugs.
Payal Rana, Michael D Aleo, Mark Gosink, Yvonne Will

Chem Res Toxicol· January 2019

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Principles of precision medicine and its application in toxicology.
Jon C Cook, Hong Wu, Michael D Aleo, Karissa Adkins

J Toxicol Sci· November 2018

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Correction to Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.
Michael D Aleo, Falgun Shah, Kan He, Paul D Bonin, A David Rodrigues

Chem Res Toxicol· June 2017

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Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.
Michael D Aleo, Falgun Shah, Kan He, Paul D Bonin, A David Rodrigues

Chem Res Toxicol· May 2017

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Inhibition of Hepatobiliary Transport Activity by the Antibacterial Agent Fusidic Acid: Insights into Factors Contributing to Conjugated Hyperbilirubinemia/Cholestasis.
Kimberly Lapham, Jonathan Novak, Lisa D Marroquin, Rachel Swiss, Shuzhen Qin, Michael D Aleo

Chem Res Toxicol· October 2016

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Setting Clinical Exposure Levels of Concern for Drug-Induced Liver Injury (DILI) Using Mechanistic in vitro Assays.
Falgun Shah, Louis Leung, Hugh A Barton, Yvonne Will, A David Rodrigues, Michael D Aleo

Toxicol Sci· October 2015

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Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump.
Michael D Aleo, Yi Luo, Rachel Swiss, Paul D Bonin, David M Potter

Hepatology· September 2014

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Improving the odds of success in drug discovery: choosing the best compounds for in vivo toxicology studies.
Travis T Wager, Bethany L Kormos, Joseph T Brady, Yvonne Will, Michael D Aleo

J Med Chem· December 2013

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1,2-naphthoquinone stimulates lipid peroxidation and cholesterol domain formation in model membranes.
Robert F Jacob, Michael D Aleo, Yehudi Self-Medlin, Colleen M Doshna, R Preston Mason

Invest Ophthalmol Vis Sci· November 2013

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Toxicity assessments of nonsteroidal anti-inflammatory drugs in isolated mitochondria, rat hepatocytes, and zebrafish show good concordance across chemical classes.
Sashi Nadanaciva, Michael D Aleo, Christopher J Strock, Donald B Stedman, Huijun Wang

Toxicol Appl Pharmacol· October 2013

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Comparisons between in vitro whole cell imaging and in vivo zebrafish-based approaches for identifying potential human hepatotoxicants earlier in pharmaceutical development.
Adrian Hill, Natalie Mesens, Margino Steemans, Jinghai James Xu, Michael D Aleo

Drug Metab Rev· February 2012

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Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States.
Antonia F Stepan, Daniel P Walker, Jonathan Bauman, David A Price, Thomas A Baillie, Michael D Aleo

Chem Res Toxicol· September 2011

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Predicting safety toleration of pharmaceutical chemical leads: cytotoxicity correlations to exploratory toxicity studies.
John W Benbow, Jiri Aubrecht, Michael J Banker, David Nettleton, Michael D Aleo

Toxicol Lett· September 2010

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Using an in vitro cytotoxicity assay to aid in compound selection for in vivo safety studies.
Nigel Greene, Michael D Aleo, Shirley Louise-May, David A Price, Yvonne Will

Bioorg Med Chem Lett· September 2010

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A current practice for predicting ocular toxicity of systemically delivered drugs.
Chris J Somps, Nigel Greene, James A Render, Michael D Aleo, Jay H Fortner

Cutan Ocul Toxicol· October 2009

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