Publications by authors named "Paul D Bonin"

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Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation.
Xiaodi Yu, Olga Plotnikova, Paul D Bonin, Timothy A Subashi, Thomas J McLellan

Elife· October 2019

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Phase I study of PF‐04895162, a Kv7 channel opener, reveals unexpected hepatotoxicity in healthy subjects, but not rats or monkeys: clinical evidence of disrupted bile acid homeostasis.
Michael D Aleo, Jiri Aubrecht, Paul D Bonin, Deborah A Burt, Jennifer Colangelo

Pharmacol Res Perspect· February 2019

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Correction to Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.
Michael D Aleo, Falgun Shah, Kan He, Paul D Bonin, A David Rodrigues

Chem Res Toxicol· June 2017

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Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.
Michael D Aleo, Falgun Shah, Kan He, Paul D Bonin, A David Rodrigues

Chem Res Toxicol· May 2017

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Assessment of Bile Salt Export Pump (BSEP) Inhibition in Membrane Vesicles Using Radioactive and LC/MS-Based Detection Methods.
Lisa D Marroquin, Paul D Bonin, Julie Keefer, Thomas Schroeter

Curr Protoc Toxicol· February 2017

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Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation.
Michael J Primiano, Bruce A Lefker, Michael R Bowman, Andrea G Bree, Cedric Hubeau, Paul D Bonin

J Immunol· September 2016

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Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities.
Eugene L Piatnitski Chekler, Jessica A Pellegrino, Thomas A Lanz, R Aldrin Denny, Andrew C Flick, Paul D Bonin

Chem Biol· December 2015

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Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases.
Roger B Ruggeri, Leonard Buckbinder, Scott W Bagley, Philip A Carpino, Edward L Conn, Paul D Bonin

J Med Chem· November 2015

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PF-1355, a mechanism-based myeloperoxidase inhibitor, prevents immune complex vasculitis and anti-glomerular basement membrane glomerulonephritis.
Wei Zheng, Roscoe Warner, Roger Ruggeri, Chunyan Su, Christian Cortes, Paul D Bonin

J Pharmacol Exp Ther· May 2015

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Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump.
Michael D Aleo, Yi Luo, Rachel Swiss, Paul D Bonin, David M Potter

Hepatology· September 2014

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From partial to full agonism: identification of a novel 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole as a full agonist of the human GPR119 receptor.
Kentaro Futatsugi, Vincent Mascitti, Cristiano R W Guimarães, Nao Morishita, Cuiman Cai, Paul D Bonin

Bioorg Med Chem Lett· January 2013

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Design and synthesis of diazatricyclodecane agonists of the G-protein-coupled receptor 119.
Etzer Darout, Ralph P Robinson, Kim F McClure, Matthew Corbett, Bryan Li, Paul D Bonin

J Med Chem· January 2013

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Oxidative metabolism of a quinoxaline derivative by xanthine oxidase in rodent plasma.
Raman Sharma, Heather Eng, Gregory S Walker, Gabriela Barreiro, Antonia F Stepan, Paul D Bonin

Chem Res Toxicol· December 2011

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Adding precise nanoliter volume capabilities to liquid-handling automation for compound screening experimentation.
Tal V Murthy, Doug Kroncke, Paul D Bonin

J Lab Autom· June 2011

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Design and evaluation of a 2-(2,3,6-trifluorophenyl)acetamide derivative as an agonist of the GPR119 receptor.
Vincent Mascitti, Benjamin D Stevens, Chulho Choi, Kim F McClure, Cristiano R W Guimarães, Paul D Bonin

Bioorg Med Chem Lett· March 2011

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Activation of the G-protein-coupled receptor 119: a conformation-based hypothesis for understanding agonist response.
Kim F McClure, Etzer Darout, Cristiano R W Guimarães, Michael P DeNinno, Vincent Mascitti, Paul D Bonin

J Med Chem· March 2011

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Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled receptor 40 (GPR40) antagonists.
Paul S Humphries, John W Benbow, Paul D Bonin, David Boyer, Shawn D Doran

Bioorg Med Chem Lett· May 2009

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Resistance mapping and mode of action of a novel class of antibacterial anthranilic acids: evidence for disruption of cell wall biosynthesis.
John E Mott, Bailin A Shaw, James F Smith, Paul D Bonin, Donna L Romero

J Antimicrob Chemother· October 2008

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Development of a fluorescence polarization assay for peptidyl-tRNA hydrolase.
Paul D Bonin, Laurence A Erickson

Anal Biochem· July 2002

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Expression, purification, and characterization of peptidyl-tRNA hydrolase from Staphylococcus aureus.
Paul D Bonin, Gil H Choi, Catherine M Trepod, John E Mott, Stephen B Lyle

Protein Expr Purif· February 2002

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