Publications by authors named "Timothy A Subashi"

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Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation.
Xiaodi Yu, Olga Plotnikova, Paul D Bonin, Timothy A Subashi, Thomas J McLellan

Elife· October 2019

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Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK).
Kim Huard, Kay Ahn, Paul Amor, David A Beebe, Kris A Borzilleri, Timothy A Subashi

J Med Chem· September 2017

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Development of a high-throughput crystal structure-determination platform for JAK1 using a novel metal-chelator soaking system.
Nicole L Caspers, Seungil Han, Francis Rajamohan, Lise R Hoth, Kieran F Geoghegan, Timothy A Subashi

Acta Crystallogr F Struct Biol Commun· November 2016

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Discovery of Selective Small Molecule Inhibitors of Monoacylglycerol Acyltransferase 3.
Kim Huard, Allyn T Londregan, Gregory Tesz, Kevin B Bahnck, Thomas V Magee, Timothy A Subashi

J Med Chem· September 2015

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Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms.
Matthew F Calabrese, Francis Rajamohan, Melissa S Harris, Nicole L Caspers, Rachelle Magyar, Timothy A Subashi

Structure· August 2014

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Novel 3-O-carbamoyl erythromycin A derivatives (carbamolides) with activity against resistant staphylococcal and streptococcal isolates.
Thomas V Magee, Seungil Han, Sandra P McCurdy, Thuy-Trinh Nguyen, Karl Granskog, Timothy A Subashi

Bioorg Med Chem Lett· March 2013

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Glycomimetic ligands for the human asialoglycoprotein receptor.
Sreeman K Mamidyala, Sanjay Dutta, Boris A Chrunyk, Cathy Préville, Hong Wang, Timothy A Subashi

J Am Chem Soc· February 2012

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Assessment of cholesteryl ester transfer protein inhibitors for interaction with proteins involved in the immune response to infection.
Ronald W Clark, David Cunningham, Yang Cong, Timothy A Subashi, George T Tkalcevic

J Lipid Res· May 2010

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Purification of the large ribosomal subunit via its association with the small subunit.
Samuel P Simons, Thomas J McLellan, Paul A Aeed, Richard P Zaniewski, Charlene R Desbonnet, Timothy A Subashi

Anal Biochem· December 2009

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A systematic study of 50S ribosomal subunit purification enabling robust crystallization.
Thomas J McLellan, Eric S Marr, Lillian M Wondrack, Timothy A Subashi, Paul A Aeed

Acta Crystallogr D Biol Crystallogr· December 2009

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Pharmacologic inhibition of site 1 protease activity inhibits sterol regulatory element-binding protein processing and reduces lipogenic enzyme gene expression and lipid synthesis in cultured cells and experimental animals.
Julie L Hawkins, Michael D Robbins, Laurie C Warren, Donghui Xia, Stephen F Petras, Timothy A Subashi

J Pharmacol Exp Ther· September 2008

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Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia.
David Cunningham, Dennis E Danley, Kieran F Geoghegan, Matthew C Griffor, Julie L Hawkins, Timothy A Subashi

Nat Struct Mol Biol· May 2007

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Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules.
Xiayang Qiu, Anil Mistry, Mark J Ammirati, Boris A Chrunyk, Ronald W Clark, Ann K Subashi, Timothy A Subashi

Nat Struct Mol Biol· February 2007

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