Publications by authors named "Hugo R Arias"

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Ibogalogs improve spatial and recognition memory in rodents through a mechanism involving 5-HT receptor activation-enhanced NMDA receptor activity in hippocampal pyramidal CA1 neurons.
Abdeslam Chagraoui, Luis A Haro Santillan, Renata Bocian, Sarah J Cohen, Yuliana E Sarmiento Ruíz, Hugo R Arias

Biomed Pharmacother· December 2025

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Isodrimenine Derivatives Selectively Inhibit Human α7-Containing Nicotinic Acetylcholine Receptors via Negative Allosteric Modulation.
Han-Shen Tae, Marcelo O Ortells, Alexandru Ciocarlan, Aculina Aricu, Lidia Lungu, Hugo R Arias

ACS Chem Neurosci· December 2025

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Ibogalogs decrease neuropathic pain in mice through a mechanism involving crosstalk between 5-HT and mGlu receptors.
Hugo R Arias, Laura Micheli, Anders A Jensen, Sonya Galant, Franck Vandermoere

Biomed Pharmacother· March 2025

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The psychoplastogens ibogaminalog and ibogainalog induce antidepressant-like activity in naïve and depressed mice by mechanisms involving 5-HT receptor activation and serotonergic transmission.
Hugo R Arias, Deborah Rudin, Dino Luethi, Jan Valenta, Anna Leśniak

Prog Neuropsychopharmacol Biol Psychiatry· January 2025

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Coronaridine congeners induce anticonvulsant activity in rodents by hippocampal mechanisms involving mainly potentiation of GABA receptors.
Hugo R Arias, Paulina Kazmierska-Grebowska, Tomasz Kowalczyk, Yaeun Shim, Bartosz Caban

Eur J Pharmacol· November 2024

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Novel psychoplastogen DM506 reduces cue-induced heroin-seeking and inhibits tonic GABA currents in the Prelimbic Cortex.
Kassandra Looschen, Shailesh Narayan Khatri, Malabika Maulik, Colin Salisbury, Alaina F Carman, Hugo R Arias

Neurochem Int· September 2024

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Non-hallucinogenic compounds derived from iboga alkaloids alleviate neuropathic and visceral pain in mice through a mechanism involving 5-HT receptor activation.
Hugo R Arias, Laura Micheli, Deborah Rudin, Ophelie Bento, Saskia Borsdorf

Biomed Pharmacother· August 2024

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Tabernanthalog and ibogainalog inhibit the α7 and α9α10 nicotinic acetylcholine receptors via different mechanisms and with higher potency than the GABA receptor and Ca2.2 channel.
Han-Shen Tae, Marcelo O Ortells, Arsalan Yousuf, Sophia Q Xu, Gustav Akk, Hugo R Arias

Biochem Pharmacol· May 2024

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Catharanthine Modulates Mesolimbic Dopamine Transmission and Nicotine Psychomotor Effects via Inhibition of α6-Nicotinic Receptors and Dopamine Transporters.
Benjamin M Williams, Nathan D Steed, Joel T Woolley, Aubrey A Moedl, Christina A Nelson, Hugo R Arias

ACS Chem Neurosci· May 2024

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To what extent may aminochrome increase the vulnerability of dopaminergic neurons in the context of Parkinson's disease.
Abdeslam Chagraoui, Youssef Anouar, Philippe De Deurwaerdere, Hugo R Arias

Int J Biochem Cell Biol· March 2024

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The novel non-hallucinogenic compound DM506 (3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole) induces sedative- and anxiolytic-like activity in mice by a mechanism involving 5-HT receptor activation.
Hugo R Arias, Deborah Rudin, Dustin J Hines, April Contreras, Alican Gulsevin

Eur J Pharmacol· March 2024

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The Antinociceptive Activity of (E)-3-(thiophen-2-yl)- N -(p-tolyl)acrylamide in Mice Is Reduced by (E)-3-(furan-2-yl)- N -methyl- N -(p-tolyl)acrylamide Through Opposing Modulatory Mechanisms at the α7 Nicotinic Acetylcholine Receptor.
Hugo R Arias, Han-Shen Tae, Laura Micheli, Arsalan Yousuf, Dina Manetti

Anesth Analg· September 2023

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Chemical, Pharmacological, and Structural Characterization of Novel Acrylamide-Derived Modulators of the GABA Receptor.
Hugo R Arias, Spencer R Pierce, Allison L Germann, Sophia Q Xu, Marcelo O Ortells

Mol Pharmacol· September 2023

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Coronaridine congeners induce sedative and anxiolytic-like activity in naïve and stressed/anxious mice by allosteric mechanisms involving increased GABA receptor affinity for GABA.
Hugo R Arias, Philippe De Deurwaerdère, Petra Scholze, Seiji Sakamoto, Itaru Hamachi

Eur J Pharmacol· August 2023

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DM506 (3-Methyl-1,2,3,4,5,6-hexahydroazepino[4,5-]indole fumarate), a Novel Derivative of Ibogamine, Inhibits α7 and α9α10 Nicotinic Acetylcholine Receptors by Different Allosteric Mechanisms.
Han-Shen Tae, Marcelo O Ortells, Bassel J Tekarli, Dina Manetti, Maria Novella Romanelli, Hugo R Arias

ACS Chem Neurosci· July 2023

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α7 Nicotinic acetylcholine receptor potentiation downregulates chemotherapy-induced inflammatory overactivation by overlapping intracellular mechanisms.
Ilias Marmouzi, Stephanie Myers, Daniel J Buck, Randall L Davis, Hugo R Arias

Int J Biochem Cell Biol· May 2023

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Mutational Analysis of Anesthetic Binding Sites and Their Effects on GABA Receptor Activation and Modulation by Positive Allosteric Modulators of the α7 Nicotinic Receptor.
Spencer R Pierce, Allison L Germann, Sophia Q Xu, Saumith L Menon, Marcelo O Ortells, Hugo R Arias

Biomolecules· April 2023

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(+)-Catharanthine and (-)-18-methoxycoronaridine induce antidepressant-like activity in mice by differently recruiting serotonergic and norepinephrinergic neurotransmission.
Hugo R Arias, Philippe De Deurwaerdère, Ali El-Kasaby, Giuseppe Di Giovanni, Sanung Eom

Eur J Pharmacol· January 2023

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Recent Advances in the Discovery of Nicotinic Acetylcholine Receptor Allosteric Modulators.
Dina Manetti, Silvia Dei, Hugo R Arias, Laura Braconi, Alessio Gabellini

Molecules· January 2023

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Modulation of the mammalian GABA receptor by type I and type II positive allosteric modulators of the α7 nicotinic acetylcholine receptor.
Hugo R Arias, Allison L Germann, Spencer R Pierce, Seiji Sakamoto, Marcelo O Ortells

Br J Pharmacol· December 2022

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(+)-Catharanthine potentiates the GABA receptor by binding to a transmembrane site at the β(+)/α(-) interface near the TM2-TM3 loop.
Hugo R Arias, Cecilia M Borghese, Allison L Germann, Spencer R Pierce, Alessandro Bonardi

Biochem Pharmacol· May 2022

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(E)-3-furan-2-yl-N-phenylacrylamide (PAM-4) decreases nociception and emotional manifestations of neuropathic pain in mice by α7 nicotinic acetylcholine receptor potentiation.
Deniz Bagdas, Gulce Sevdar, Zulfiye Gul, Rabha Younis, Sinan Cavun, Hugo R Arias

Neurol Res· December 2021

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Type I and type II positive allosteric modulators of α7 nicotinic acetylcholine receptors induce antidepressant-like activity in mice by a mechanism involving receptor potentiation but not neurotransmitter reuptake inhibition. Correlation with mTOR intracellular pathway activation.
Katarzyna M Targowska-Duda, Barbara Budzynska, Agnieszka Michalak, Artur Wnorowski, Claus J Loland, Hugo R Arias

Eur Neuropsychopharmacol· November 2021

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Is the Antidepressant Activity of Selective Serotonin Reuptake Inhibitors Mediated by Nicotinic Acetylcholine Receptors?
Hugo R Arias, Katarzyna M Targowska-Duda, Jesús García-Colunga, Marcelo O Ortells

Molecules· April 2021

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()-3-Furan-2-yl---tolyl-acrylamide and its Derivative DM489 Decrease Neuropathic Pain in Mice Predominantly by α7 Nicotinic Acetylcholine Receptor Potentiation.
Hugo R Arias, Carla Ghelardini, Elena Lucarini, Han-Shen Tae, Arsalan Yousuf

ACS Chem Neurosci· November 2020

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