Publications by authors named "Hung-Ching Chen"

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The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC.
Jonathan Richard, Michael W Grunst, Ling Niu, Marco A Díaz-Salinas, Li Zhu, Hung-Ching Chen

Nat Commun· December 2025

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Stoichiometry of HIV-1 envelope glycoprotein protomers with changes that stabilize or destabilize the pretriggered conformation.
Zhiqing Zhang, Saumya Anang, Qian Wang, Hanh T Nguyen, Hung-Ching Chen

mBio· November 2025

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A gp41 HR2 residue modulates the susceptibility of HIV-1 envelope glycoproteins to small molecule inhibitors targeting gp120.
Debashree Chatterjee, Ling Niu, Halima Medjahed, Shilei Ding, Mehdi Benlarbi, Hung-Ching Chen

J Virol· April 2025

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Three families of CD4-induced antibodies are associated with the capacity of plasma from people living with HIV to mediate ADCC in the presence of CD4-mimetics.
Alexandra Tauzin, Lorie Marchitto, Étienne Bélanger, Mehdi Benlarbi, Guillaume Beaudoin-Bussières, Hung-Ching Chen

J Virol· October 2024

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The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity.
Lorie Marchitto, Jonathan Richard, Jérémie Prévost, Alexandra Tauzin, Derek Yang, Hung-Ching Chen

J Virol· October 2024

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Stoichiometry of HIV-1 Envelope Glycoprotein Protomers with Changes That Stabilize or Destabilize the Pretriggered Conformation.
Zhiqing Zhang, Saumya Anang, Qian Wang, Hanh T Nguyen, Hung-Ching Chen

bioRxiv· October 2024

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The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC.
Jonathan Richard, Michael W Grunst, Ling Niu, Marco A Díaz-Salinas, William D Tolbert, Hung-Ching Chen

bioRxiv· August 2024

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NTB-A and 2B4 Natural Killer Cell Receptors Modulate the Capacity of a Cocktail of Non-Neutralizing Antibodies and a Small CD4-Mimetic to Eliminate HIV-1-Infected Cells by Antibody-Dependent Cellular Cytotoxicity.
Lorie Marchitto, Alexandra Tauzin, Mehdi Benlarbi, Guillaume Beaudoin-Bussières, Katrina Dionne, Hung-Ching Chen

Viruses· July 2024

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Three families of CD4-induced antibodies are associated with the capacity of plasma from people living with HIV to mediate ADCC in presence of CD4-mimetics.
Alexandra Tauzin, Lorie Marchitto, Étienne Bélanger, Mehdi Benlarbi, Guillaume Beaudoin-Bussières, Hung-Ching Chen

medRxiv· June 2024

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The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity.
Lorie Marchitto, Jonathan Richard, Jérémie Prévost, Alexandra Tauzin, Derek Yang, Hung-Ching Chen

bioRxiv· June 2024

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Soluble CD4 and low molecular weight CD4-mimetic compounds sensitize cells to be killed by anti-HIV cytotoxic immunoconjugates.
Seth H Pincus, Megan Stackhouse, Connie Watt, Kelli Ober, Frances M Cole, Hung-Ching Chen

J Virol· October 2023

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Alterations in gp120 glycans or the gp41 fusion peptide-proximal region modulate the stability of the human immunodeficiency virus (HIV-1) envelope glycoprotein pretriggered conformation.
Zhiqing Zhang, Qian Wang, Hanh T Nguyen, Hung-Ching Chen, Ta-Jung Chiu

J Virol· September 2023

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Temsavir blocks the immunomodulatory activities of HIV-1 soluble gp120.
Jonathan Richard, Jérémie Prévost, Catherine Bourassa, Nathalie Brassard, Marianne Boutin, Hung-Ching Chen

Cell Chem Biol· May 2023

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Indoline CD4-mimetic compounds mediate potent and broad HIV-1 inhibition and sensitization to antibody-dependent cellular cytotoxicity.
Christopher J Fritschi, Saumya Anang, Zhen Gong, Mohammadjavad Mohammadi, Jonathan Richard, Hung-Ching Chen

Proc Natl Acad Sci U S A· March 2023

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Small CD4 mimetics sensitize HIV-1-infected macrophages to antibody-dependent cellular cytotoxicity.
Annemarie Laumaea, Lorie Marchitto, Shilei Ding, Guillaume Beaudoin-Bussières, Jérémie Prévost, Hung-Ching Chen

Cell Rep· January 2023

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HIV-1 Vpu restricts Fc-mediated effector functions in vivo.
Jérémie Prévost, Sai Priya Anand, Jyothi Krishnaswamy Rajashekar, Li Zhu, Jonathan Richard, Hung-Ching Chen, Yaozong Chen

Cell Rep· November 2022

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Characterization of Human Immunodeficiency Virus (HIV-1) Envelope Glycoprotein Variants Selected for Resistance to a CD4-Mimetic Compound.
Saumya Anang, Jonathan Richard, Catherine Bourassa, Guillaume Goyette, Ta-Jung Chiu, Hung-Ching Chen

J Virol· September 2022

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HIV-1 Envelope Glycoproteins Proteolytic Cleavage Protects Infected Cells from ADCC Mediated by Plasma from Infected Individuals.
Jérémie Prévost, Halima Medjahed, Dani Vézina, Hung-Ching Chen, Beatrice H Hahn

Viruses· November 2021

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HIV-1 Envelope Glycoprotein Cell Surface Localization Is Associated with Antibody-Induced Internalization.
Sai Priya Anand, Jérémie Prévost, Jade Descôteaux-Dinelle, Jonathan Richard, Dung N Nguyen, Hung-Ching Chen

Viruses· September 2021

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Modulating HIV-1 envelope glycoprotein conformation to decrease the HIV-1 reservoir.
Jyothi K Rajashekar, Jonathan Richard, Jagadish Beloor, Jérémie Prévost, Sai Priya Anand, Hung-Ching Chen

Cell Host Microbe· June 2021

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Development of an Effective Scalable Enantioselective Synthesis of the HIV-1 Entry Inhibitor BNM-III-170 as the Bis-Trifluoroacetate Salt.
Junhua Chen, Jun Park, Sharon M Kirk, Hung-Ching Chen, Xiangqin Li

Org Process Res Dev· November 2019

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Recovery of oxidative stress-induced damage in Cisd2-deficient cardiomyocytes by sustained release of ferulic acid from injectable hydrogel.
Yung-Hsin Cheng, Feng-Huei Lin, Chien-Ying Wang, Chen-Yuan Hsiao, Hung-Ching Chen

Biomaterials· October 2016

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Reverse engineering a social agent-based hidden markov model--visage.
Hung-Ching Justin Chen, Mark Goldberg, Malik Magdon-Ismail, William A Wallace

Int J Neural Syst· December 2008

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