Publications by authors named "William D Tolbert"

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The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC.
Jonathan Richard, Michael W Grunst, Ling Niu, Marco A Díaz-Salinas, Li Zhu, William D Tolbert

Nat Commun· December 2025

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The impact of N-glycan conformational entropy on the binding affinity of Fc γ receptor IIIa/CD16a.
Paul G Kremer, William D Tolbert, Eliza Gazaway, Braulio G Hernandez, Marek K Korzeniowski

Structure· December 2025

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Optimization of VE607 to generate analogs with improved neutralization activities against SARS-CoV-2 variants.
Shilei Ding, Derek Yang, Irfan Ullah, Ling Niu, Matthew Unger, William D Tolbert

J Virol· November 2025

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Fostemsavir Decreases the Levels of Anti-gp120 CD4-Induced Antibodies in Heavily Treatment-Experienced People With HIV.
Mehdi Benlarbi, Jonathan Richard, Tommaso Clemente, Catherine Bourassa, William D Tolbert

J Infect Dis· September 2025

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CD4 T cell counts are inversely correlated with anti-gp120 cluster A antibodies in antiretroviral therapy-treated PLWH.
Mehdi Benlarbi, Jonathan Richard, Tommaso Clemente, Catherine Bourassa, William D Tolbert

EBioMedicine· August 2025

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CD4-mimetics sensitize HIV-infected cells to ADCC mediated by plasma from persons with early-stage HIV-1 infection.
Shilei Ding, Alexandra Tauzin, Delia Pinto-Santini, Sayan Dasgupta, Derek Yang, William D Tolbert

J Virol· August 2025

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A Dual-Specificity d-Peptide Antagonist of MDM2 and MDMX for Antitumor Immunotherapy.
Chongbing Liao, Jin Yan, William D Tolbert, Xishan Chen, Marzena Pazgier

J Med Chem· August 2025

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A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV.
Mohammad M Sajadi, Abdolrahim Abbasi, Zahra Rikhtegaran Tehrani, Christine Siska, Rutilio Clark, William D Tolbert

Structure· July 2025

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A gp41 HR2 residue modulates the susceptibility of HIV-1 envelope glycoproteins to small molecule inhibitors targeting gp120.
Debashree Chatterjee, Ling Niu, Halima Medjahed, Shilei Ding, Mehdi Benlarbi, William D Tolbert

J Virol· April 2025

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CD4 T cell counts are inversely correlated with anti-cluster A antibodies in antiretroviral therapy-treated PLWH.
Mehdi Benlarbi, Jonathan Richard, Tommaso Clemente, Catherine Bourassa, William D Tolbert

medRxiv· February 2025

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Optimization of a Piperidine CD4-Mimetic Scaffold Sensitizing HIV-1 Infected Cells to Antibody-Dependent Cellular Cytotoxicity.
Daniel Lee, Ling Niu, Shilei Ding, Huile Zhu, William D Tolbert

ACS Med Chem Lett· November 2024

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Three families of CD4-induced antibodies are associated with the capacity of plasma from people living with HIV to mediate ADCC in the presence of CD4-mimetics.
Alexandra Tauzin, Lorie Marchitto, Étienne Bélanger, Mehdi Benlarbi, Guillaume Beaudoin-Bussières, William D Tolbert

J Virol· October 2024

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The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity.
Lorie Marchitto, Jonathan Richard, Jérémie Prévost, Alexandra Tauzin, Derek Yang, William D Tolbert

J Virol· October 2024

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The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC.
Jonathan Richard, Michael W Grunst, Ling Niu, Marco A Díaz-Salinas, William D Tolbert

bioRxiv· August 2024

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Three families of CD4-induced antibodies are associated with the capacity of plasma from people living with HIV to mediate ADCC in presence of CD4-mimetics.
Alexandra Tauzin, Lorie Marchitto, Étienne Bélanger, Mehdi Benlarbi, Guillaume Beaudoin-Bussières, William D Tolbert

medRxiv· June 2024

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The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity.
Lorie Marchitto, Jonathan Richard, Jérémie Prévost, Alexandra Tauzin, Derek Yang, William D Tolbert

bioRxiv· June 2024

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Plasma Human Immunodeficiency Virus 1 Soluble Glycoprotein 120 Association With Correlates of Immune Dysfunction and Inflammation in Antiretroviral Therapy-Treated Individuals With Undetectable Viremia.
Mehdi Benlarbi, Jonathan Richard, Catherine Bourassa, William D Tolbert, Carl Chartrand-Lefebvre

J Infect Dis· March 2024

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Defining genetic diversity of rhesus macaque Fcγ receptors with long-read RNA sequencing.
Haleigh E Conley, Max M He, David Easterhoff, Hélène Fradin Kirshner, Sarah L Cocklin, William D Tolbert

Front Immunol· January 2024

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Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir.
Jérémie Prévost, Yaozong Chen, Fei Zhou, William D Tolbert, Romain Gasser

Nat Commun· October 2023

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Plasmatic HIV-1 soluble gp120 is associated with immune dysfunction and inflammation in ART-treated individuals with undetectable viremia.
Mehdi Benlarbi, Jonathan Richard, Catherine Bourassa, William D Tolbert, Carl Chartrand-Lefebvre

medRxiv· August 2023

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The molecular basis of the neutralization breadth of the RBD-specific antibody CoV11.
William D Tolbert, Yaozong Chen, Lulu Sun, Mehdi Benlarbi, Shilei Ding

Front Immunol· June 2023

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Temsavir blocks the immunomodulatory activities of HIV-1 soluble gp120.
Jonathan Richard, Jérémie Prévost, Catherine Bourassa, Nathalie Brassard, Marianne Boutin, William D Tolbert

Cell Chem Biol· May 2023

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Piperidine CD4-Mimetic Compounds Expose Vulnerable Env Epitopes Sensitizing HIV-1-Infected Cells to ADCC.
Shilei Ding, William D Tolbert, Huile Zhu, Daniel Lee, Lorie Marchitto

Viruses· May 2023

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Structure-function Analyses Reveal Key Molecular Determinants of HIV-1 CRF01_AE Resistance to the Entry Inhibitor Temsavir.
Jérémie Prévost, Yaozong Chen, Fei Zhou, William D Tolbert, Romain Gasser

bioRxiv· April 2023

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Piperidine CD4-mimetic compounds expose vulnerable Env epitopes sensitizing HIV-1-infected cells to ADCC.
Shilei Ding, William D Tolbert, Huile Zhu, Daniel Lee, Tyler Higgins

bioRxiv· March 2023

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