Publications by authors named "Hussein I El Subbagh"

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Pyrazolopyridine-Containing Compounds as Multitargeted Anti-Alzheimer Agents: Synthesis, Biological Evaluation, and In Silico Studies.
Omnia M Waly, Selwan M El-Sayed, Mariam A Ghaly, Hussein I El-Subbagh

Arch Pharm (Weinheim)· June 2025

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Synthesis, molecular modeling simulations and anticancer activity of some new Imidazo[2,1-b]thiazole analogues as EGFR/HER2 and DHFR inhibitors.
Esraa A Moharram, Selwan M El-Sayed, Hazem A Ghabbour, Hussein I El-Subbagh

Bioorg Chem· September 2024

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Multi-targeted anti-Alzheimer's agents: Synthesis, biological evaluation, and molecular modeling study of some pyrazolopyridine hybrids.
Omnia M Waly, Selwan M El-Sayed, Mariam A Ghaly, Hussein I El-Subbagh

Eur J Med Chem· December 2023

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Editorial: Recent advances in the research and development of kinase-inhibitory anticancer molecules.
Ahmed A Al-Karmalawy, Hussein I El-Subbagh, Liliya Logoyda, Roman B Lesyk, Mohammed I El-Gamal

Front Chem· November 2023

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Hydrazinecarbonyl-thiazol-2-acetamides with pronounced apoptotic behavior: synthesis, in vitro/in vivo anti-proliferative activity and molecular modeling simulations.
Reham W Elsayed, Said M Bayoumi, Hussein I El-Subbagh, Selwan M El-Sayed

Bioorg Med Chem Lett· May 2023

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Discovery of new pyridine heterocyclic hybrids; design, synthesis, dynamic simulations, and and breast cancer biological assays.
Menna M Abdelshaheed, Hussein I El Subbagh, Mohamed A Tantawy, Reem T Attia, Khairia M Youssef

RSC Adv· May 2023

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New quinazolinone-based derivatives as DHFR/EGFR-TK inhibitors: Synthesis, molecular modeling simulations, and anticancer activity.
Yomna I El-Gazzar, Heba R Ghaiad, Ahmed M El Kerdawy, Riham F George, Hanan H Georgey, Hussein I El-Subbagh

Arch Pharm (Weinheim)· January 2023

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New thiazole-based derivatives as EGFR/HER2 and DHFR inhibitors: Synthesis, molecular modeling simulations and anticancer activity.
Mohamed A Sabry, Mariam A Ghaly, Azza R Maarouf, Hussein I El-Subbagh

Eur J Med Chem· November 2022

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Taguchi Approach for Optimization of a Green Quantitative 1H-NMR Practice for Characterization of Levetiracetam and Brivaracetam in Pharmaceuticals.
Noura M Mansour, Dina T El-Sherbiny, Fawzia A Ibrahim, Hussein I El-Subbagh

J AOAC Int· October 2022

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New phthalimide-based derivatives as EGFR-TK inhibitors: Synthesis, biological evaluation, and molecular modeling study.
Nayera I Mansour, Selwan M El-Sayed, Nadia S El-Gohary, Naglaa I Abdel-Aziz, Hussein I El-Subbagh

Bioorg Chem· October 2022

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Thiazole-based SARS-CoV-2 protease (COV M ) inhibitors: Design, synthesis, enzyme inhibition, and molecular modeling simulations.
Reham W Elsayed, Mohamed A Sabry, Hussein I El-Subbagh, Said M Bayoumi, Selwan M El-Sayed

Arch Pharm (Weinheim)· September 2022

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Synthesis, biological evaluation, and molecular modeling simulations of new heterocyclic hybrids as multi-targeted anti-Alzheimer's agents.
Omnia M Waly, Kareem M Saad, Hussein I El-Subbagh, Said M Bayomi, Mariam A Ghaly

Eur J Med Chem· March 2022

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2-Substituted-mercapto-quinazolin-4(3H)-ones as DHFR Inhibitors.
Hussein I El-Subbagh, Mohamed A Sabry

Mini Rev Med Chem· December 2021

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Nanomolar potency of imidazo[2,1-b]thiazole analogs as indoleamine 2,3-dioxygenase inhibitors.
Menna A Ewida, Heba A Ewida, Mahmoud S Ahmed, Heba Abdelrasheed Allam, Ramzia I ElBagary, Hussein I El-Subbagh

Arch Pharm (Weinheim)· November 2021

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3-Methyl-imidazo[2,1-b]thiazole derivatives as a new class of antifolates: Synthesis, in vitro/in vivo bio-evaluation and molecular modeling simulations.
Menna A Ewida, Heba A Ewida, Mahmoud S Ahmed, Heba Abdelrasheed Allam, Ramzia I ElBagary, Hussein I El-Subbagh

Bioorg Chem· October 2021

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Novel GABA Agonist Entities: Pharmacological Investigation and Molecular Modeling Study of Thiazolo- and Thiadiazolo-[3,2-a][1,3]diazepine Analogs.
Hussein I El-Subbagh

Mini Rev Med Chem· August 2021

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Novel 1,2,4-oxadiazole-chalcone/oxime hybrids as potential antibacterial DNA gyrase inhibitors: Design, synthesis, ADMET prediction and molecular docking study.
Tarek S Ibrahim, Ahmad J Almalki, Amr H Moustafa, Rasha M Allam, Gamal El-Din A Abuo-Rahma, Hussein I El Subbagh

Bioorg Chem· June 2021

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Design, synthesis and molecular modeling of novel aryl carboximidamides and 3-aryl-1,2,4-oxadiazoles derived from indomethacin as potent anti-inflammatory iNOS/PGE2 inhibitors.
Mamdouh F A Mohamed, Adel A Marzouk, Ayman Nafady, Dalia A El-Gamal, Rasha M Allam, Hussein I El Subbagh

Bioorg Chem· December 2020

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Multiobjective optimization of microemulsion- thin layer chromatography with image processing as analytical platform for determination of drugs in plasma using desirability functions.
Noura H Abou-Taleb, Dina T El-Sherbiny, Nahed M El-Enany, Hussein I El-Subbagh

J Chromatogr A· May 2020

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Synthesis, antitumor testing and molecular modeling study of some new 6-substituted amido, azo or thioureido-quinazolin-4(3H)-ones.
Mohamed A Sabry, Heba A Ewida, Ghada S Hassan, Mariam A Ghaly, Hussein I El-Subbagh

Bioorg Chem· July 2019

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Imidazo[2',1':2,3]thiazolo[4,5-d]pyridazinone as a new scaffold of DHFR inhibitors: Synthesis, biological evaluation and molecular modeling study.
Menna A Ewida, Dalal A Abou El Ella, Deena S Lasheen, Heba A Ewida, Yomna I El-Gazzar, Hussein I El-Subbagh

Bioorg Chem· October 2018

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Thiazolo[4,5-d]pyridazine analogues as a new class of dihydrofolate reductase (DHFR) inhibitors: Synthesis, biological evaluation and molecular modeling study.
Menna A Ewida, Dalal A Abou El Ella, Deena S Lasheen, Heba A Ewida, Yomna I El-Gazzar, Hussein I El-Subbagh

Bioorg Chem· October 2017

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Synthesis, biological evaluation and molecular modeling study of new (1,2,4-triazole or 1,3,4-thiadiazole)-methylthio-derivatives of quinazolin-4(3H)-one as DHFR inhibitors.
Yomna I El-Gazzar, Hanan H Georgey, Shahenda M El-Messery, Heba A Ewida, Ghada S Hassan, Hussein I El-Subbagh

Bioorg Chem· June 2017

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Thiadiazolodiazepine analogues as a new class of neuromuscular blocking agents: Synthesis, biological evaluation and molecular modeling study.
Hussein I El-Subbagh, Adel S El-Azab, Ghada S Hassan, Shahenda M El-Messery, Alaa A-M Abdel-Aziz

Eur J Med Chem· January 2017

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Synthesis, biological evaluation and molecular modeling study of thiadiazolo[3,2-a][1,3]diazepine analogues of HIE-124 as a new class of short acting hypnotics.
Hussein I El-Subbagh, Ghada S Hassan, Kamal E H El-Taher, Shahenda M El-Messery, Adel S Al-Azab

Eur J Med Chem· November 2016

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