Publications by authors named "Iain Greig"

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Phenotypic pharmacology of novel Complex I inhibitors eliciting tissue repair concurrent to control of inflammation.
Lisa Patel, Fatima Garcia-Raposo, Benjamin Moore, James Wood, Lily Morley, Iain R Greig

J Pharmacol Exp Ther· September 2025

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Synthetic Retinoids for the Modulation of Genomic and Nongenomic Processes in Neurodegenerative Diseases.
Abbey M Butler, David R Chisholm, Charles W E Tomlinson, Thabat Khatib, Jason Clark, Iain R Greig

ACS Omega· June 2025

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A Tourette Syndrome/ADHD-like Phenotype Results from Postnatal Disruption of CB and CB Receptor Signalling.
Victoria Gorberg, Tamar Harpaz, Emilya Natali Shamir, Orit Diana Karminsky, Ester Fride, Iain R Greig

Int J Mol Sci· June 2025

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Designer cannabinoids could be the key to pain relief without adverse effects.
Iain R Greig, Ruth A Ross

Nature· April 2025

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Fluorinated perhexiline derivative attenuates vascular proliferation in pulmonary arterial hypertension smooth muscle cells.
Kayleigh Griffiths, Roger J Grand, Ian Horan, Michelangelo Certo, Ross C Keeler, Iain Greig

Vascul Pharmacol· September 2024

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CB1 Receptor Negative Allosteric Modulators as a Potential Tool to Reverse Cannabinoid Toxicity.
Audrey Flavin, Paniz Azizi, Natalia Murataeva, Kyle Yust, Wenwen Du, Iain Greig

Molecules· April 2024

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The atypical 'hippocampal' glutamate receptor coupled to phospholipase D that controls stretch-sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2.
Karen J Thompson, Sonia Watson, Chiara Zanato, Sergio Dall'Angelo, Joriene C De Nooij, Iain Greig

Exp Physiol· January 2024

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Small-molecule targeting AMPA-mediated excitotoxicity has therapeutic effects in mouse models for multiple sclerosis.
Dongxu Zhai, Shuxin Yan, James Samsom, Le Wang, Ping Su, Iain R Greig

Sci Adv· December 2023

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In Vitro Characterization of 6-Methyl-3-(2-nitro-1-(thiophen-2-yl)ethyl)-2-phenyl-1-indole (ZCZ011) at the Type 1 Cannabinoid Receptor: Allosteric Agonist or Allosteric Modulator?
Hayley M Green, David B Finlay, Ruth A Ross, Iain R Greig, Stephen B Duffull

ACS Pharmacol Transl Sci· December 2022

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Motor-like Tics are Mediated by CB Cannabinoid Receptor-dependent and Independent Mechanisms Associated with Age and Sex.
Victoria Gorberg, Veronika Borisov, Iain R Greig, Roger G Pertwee, Peter McCaffery

Mol Neurobiol· August 2022

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Antidepressant activity of pharmacological and genetic deactivation of the small-conductance calcium-activated potassium channel subtype-3.
Mina G Nashed, Shannon Waye, S M Nageeb Hasan, Diana Nguyen, Micaela Wiseman, Iain R Greig

Psychopharmacology (Berl)· January 2022

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A novel allosteric modulator of the cannabinoid CB receptor ameliorates hyperdopaminergia endophenotypes in rodent models.
Catharine A Mielnik, Kim S Sugamori, David B Finlay, Hayley H A Thorpe, Matthieu Schapira, Iain R Greig

Neuropsychopharmacology· January 2021

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Evidence that cannabinoid CB1 receptors regulate intraocular pressure via two opposing mechanisms.
Sally Miller, Laura Daily, Maya Ploss, Iain Greig, Ruth Ross

Exp Eye Res· November 2020

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Genomic and non-genomic pathways are both crucial for peak induction of neurite outgrowth by retinoids.
Thabat Khatib, Pietro Marini, Sudheer Nunna, David R Chisholm, Andrew Whiting, Iain R Greig

Cell Commun Signal· May 2019

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The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB Receptor Positive Allosteric Modulators.
Chih-Chung Tseng, Gemma Baillie, Giulia Donvito, Mohammed A Mustafa, Sophie E Juola, Iain R Greig

J Med Chem· May 2019

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Effects of glycol-split low molecular weight heparin on placental, endothelial, and anti-inflammatory pathways relevant to preeclampsia.
Jovian M Wat, Krista Hawrylyshyn, Dora Baczyk, Iain R Greig, John C Kingdom

Biol Reprod· November 2018

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Small Molecule Inhibitors of Metabolic Enzymes Repurposed as a New Class of Anthelmintics.
Rahul Tyagi, Amarendar Reddy Maddirala, Mostafa Elfawal, Chelsea Fischer, Christina A Bulman, Iain R Greig

ACS Infect Dis· July 2018

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Enantiomer-specific positive allosteric modulation of CB signaling in autaptic hippocampal neurons.
Jose Mitjavila, Danielle Yin, Pushkar M Kulkarni, Chiara Zanato, Ganesh A Thakur, Iain Greig

Pharmacol Res· March 2018

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Development of Fluorinated Analogues of Perhexiline with Improved Pharmacokinetic Properties and Retained Efficacy.
Chih-Chung Tseng, Hannah Noordali, Monica Sani, Melanie Madhani, Denis M Grant, Iain R Greig

J Med Chem· April 2017

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Development of indole sulfonamides as cannabinoid receptor negative allosteric modulators.
Iain R Greig, Gemma L Baillie, Mostafa Abdelrahman, Laurent Trembleau, Ruth A Ross

Bioorg Med Chem Lett· September 2016

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A Cannabinoid CB1 Receptor-Positive Allosteric Modulator Reduces Neuropathic Pain in the Mouse with No Psychoactive Effects.
Bogna M Ignatowska-Jankowska, Gemma L Baillie, Steven Kinsey, Molly Crowe, Sudeshna Ghosh, Iain R Greig

Neuropsychopharmacology· December 2015

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Tyrphostin AG126 exerts neuroprotection in CNS inflammation by a dual mechanism.
Christiane Menzfeld, Michael John, Denise van Rossum, Tommy Regen, Jörg Scheffel, Iain Greig

Glia· June 2015

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HPLC-MS-MS Determination of ZCZ-011, A Novel Pharmacological Tool for Investigation of the Cannabinoid Receptor in Mouse Brain Using Clean Screen FASt™ Column Extraction.
Justin L Poklis, Deborah J Clay, Bogna M Ignatowska-Jankowska, Chiara Zanato, Ruth A Ross, Iain R Greig

J Anal Toxicol· June 2015

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Modulation of food consumption and sleep-wake cycle in mice by the neutral CB1 antagonist ABD459.
Anushka V Goonawardena, Andrea Plano, Lianne Robinson, Ruth Ross, Iain Greig

Behav Pharmacol· April 2015

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In-vivo pharmacological evaluation of the CB1-receptor allosteric modulator Org-27569.
Thomas F Gamage, Bogna M Ignatowska-Jankowska, Jenny L Wiley, Mostafa Abdelrahman, Laurent Trembleau, Iain R Greig

Behav Pharmacol· April 2014

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