Publications by authors named "Iain Manfield"

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Sequence rules for a long SPOP-binding degron required for protein ubiquitylation.
Linda Makhlouf, Mukul Mishra, Hannah Makhlouf, Iain Manfield, Luca Busino

Biochem J· May 2025

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Structure and unusual binding mechanism of the hyaluronan receptor LYVE-1 mediating leucocyte entry to lymphatics.
Fouzia Bano, Suneale Banerji, Tao Ni, Dixy E Green, Kalila R Cook, Iain W Manfield

Nat Commun· March 2025

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Mutations in the N-domain of aryl hydrocarbon receptor interacting protein affect interactions with heat shock protein 90β and phosphodiesterase 4A5.
Marita Vella, Iain W Manfield, Brandon C Seychell, Chi H Trinh, Robert Rambo

Biochimie· January 2025

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Chaperone BiP controls ER stress sensor Ire1 through interactions with its oligomers.
Sam Dawes, Nicholas Hurst, Gabriel Grey, Lukasz Wieteska, Nathan V Wright, Iain W Manfield

Life Sci Alliance· October 2024

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Dual client binding sites in the ATP-independent chaperone SurA.
Bob Schiffrin, Joel A Crossley, Martin Walko, Jonathan M Machin, G Nasir Khan, Iain W Manfield

Nat Commun· September 2024

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Affimer reagents enable targeted delivery of therapeutic agents and RNA via virus-like particles.
Sophie E Roberts, Heather L Martin, Danah Al-Qallaf, Anna A Tang, Christian Tiede, Iain W Manfield

iScience· August 2024

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Polyvalent Glycomimetic-Gold Nanoparticles Revealing Critical Roles of Glycan Display on Multivalent Lectin-Glycan Interaction Biophysics and Antiviral Properties.
Xinyu Ning, Darshita Budhadev, Sara Pollastri, Inga Nehlmeier, Amy Kempf, Iain Manfield

JACS Au· August 2024

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The Mutagenic Plasticity of the Cholera Toxin B-Subunit Surface Residues: Stability and Affinity.
Cheuk W Au, Iain Manfield, Michael E Webb, Emanuele Paci, W Bruce Turnbull

Toxins (Basel)· March 2024

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Intrinsic disorder and conformational coexistence in auxin coreceptors.
Sigurd Ramans-Harborough, Arnout P Kalverda, Iain W Manfield, Gary S Thompson, Martin Kieffer

Proc Natl Acad Sci U S A· October 2023

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Affimer-mediated locking of p21-activated kinase 5 in an intermediate activation state results in kinase inhibition.
Heather L Martin, Amy L Turner, Julie Higgins, Anna A Tang, Christian Tiede, Iain W Manfield

Cell Rep· October 2023

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A bovine antibody possessing an ultralong complementarity-determining region CDRH3 targets a highly conserved epitope in sarbecovirus spike proteins.
Matthew J Burke, James N F Scott, Thomas C Minshull, Zeqian Gao, Iain Manfield

J Biol Chem· December 2022

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Dataset of high-throughput ligand screening against the RNA Packaging Signals regulating Hepatitis B Virus nucleocapsid formation.
Fardokht Abulwerdi, Farzad Fatehi, Iain W Manfield, Stuart F J Le Grice, John S Schneekloth

Data Brief· June 2022

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Dysregulation of Hepatitis B Virus Nucleocapsid Assembly in vitro by RNA-binding Small Ligands.
Nikesh Patel, Fardokht Abulwerdi, Farzad Fatehi, Iain W Manfield, Stuart Le Grice

J Mol Biol· May 2022

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A Comparative Assessment Study of Known Small-molecule GPVI Modulators.
Holly Foster, Clare Wilson, Julia S Gauer, Rui-Gang Xu, Mark J Howard, Iain W Manfield

ACS Med Chem Lett· February 2022

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Tuning the rate of aggregation of hIAPP into amyloid using small-molecule modulators of assembly.
Yong Xu, Roberto Maya-Martinez, Nicolas Guthertz, George R Heath, Iain W Manfield

Nat Commun· February 2022

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GPVI (Glycoprotein VI) Interaction With Fibrinogen Is Mediated by Avidity and the Fibrinogen αC-Region.
Rui-Gang Xu, Julia S Gauer, Stephen R Baker, Alexandre Slater, Eleyna M Martin, Iain W Manfield

Arterioscler Thromb Vasc Biol· March 2021

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Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly.
Guoliang Chai, Alice Webb, Chen Li, Danny Antaki, Sangmoon Lee, Iain W Manfield

Neuron· January 2021

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A missense variant in specificity protein 6 (SP6) is associated with amelogenesis imperfecta.
Claire E L Smith, Laura L E Whitehouse, James A Poulter, Laura Wilkinson Hewitt, Fatima Nadat, Iain W Manfield

Hum Mol Genet· June 2020

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Defining the remarkable structural malleability of a bacterial surface protein Rib domain implicated in infection.
Fiona Whelan, Aleix Lafita, Samuel C Griffiths, Rachael E M Cooper, Jean L Whittingham, Iain W Manfield

Proc Natl Acad Sci U S A· December 2019

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Affimer proteins as a tool to modulate fibrinolysis, stabilize the blood clot, and reduce bleeding complications.
Katherine J Kearney, Nikoletta Pechlivani, Rhodri King, Christian Tiede, Fladia Phoenix, Iain W Manfield

Blood· March 2019

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The effects of irradiation on the biological and biomechanical properties of an acellular porcine superflexor tendon graft for cruciate ligament repair.
Jennifer H Edwards, Anthony Herbert, Gemma L Jones, Iain W Manfield, John Fisher

J Biomed Mater Res B Appl Biomater· November 2017

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AtSPX1 affects the AtPHR1-DNA-binding equilibrium by binding monomeric AtPHR1 in solution.
Wanjun Qi, Iain W Manfield, Stephen P Muench, Alison Baker

Biochem J· October 2017

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TRPA1-FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p.
Jonathan Berrout, Eleni Kyriakopoulou, Lavanya Moparthi, Alexandra S Hogea, Liza Berrout, Iain Manfield

Nat Commun· October 2017

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Affimer proteins are versatile and renewable affinity reagents.
Christian Tiede, Robert Bedford, Sophie J Heseltine, Gina Smith, Imeshi Wijetunga, Iain Manfield

Elife· June 2017

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Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4.
Azhar Maqbool, Emma J Spary, Iain W Manfield, Michaela Ruhmann, Lorena Zuliani-Alvarez

World J Cardiol· May 2016

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