Publications by authors named "Iain Tan"

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Severity of Respiratory Syncytial Virus and Other Respiratory Viruses Versus Seasonal Influenza Among Hospitalized Patients With Cancer.
Liang En Wee, Leicester Shawn Alcantara, May Kyawt Aung, Shalvi Arora, Jean Xiang Ying Sim, Tertius Tansloan Tuy, Wei Chong Tan, Iain Beehuat Tan, Kelvin Bryan Tan, Ban Hock Tan

Open Forum Infect Dis· December 2025

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Genomic platform specific polygenic risk scores impact breast cancer risk stratification.
Peh Joo Ho, Alexis Jiaying Khng, Joanna Hui Juan Tan, Pierre-Alexis Vincent Goy, Kayla Aisha Kamila, Iain Bee Huat Tan

Commun Med (Lond)· December 2025

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Pirin Transcriptionally Regulates PLA2G4A To Inhibit Ferroptosis in Colorectal Cancer via Lipid Profile Remodeling.
Wei Shi, Yue Qi Ong, Prativa Majee, Esther Sm Wong, Amhed Missael Vargas Velazquez, Ker Kan Tan, Iain Beehuat Tan

Adv Sci (Weinh)· December 2025

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Comprehensive benchmarking of methods for mutation calling in circulating tumor DNA.
Hanaé Carrié, Ngak Leng Sim, Pui Mun Wong, Anna Gan, Yi Ting Lau, Iain Tan

Nat Commun· December 2025

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Modeling oxaliplatin resistance in colorectal cancer reveals a SERPINE1-based gene signature (RESIST-M) and therapeutic strategies for pro-metastatic CMS4 subtype.
Stephen Qi Rong Wong, Mohua Das, Kenzom Tenzin, Niranjan Shirgaonkar, Huiwen Chua, Matan Thangavelu Thangavelu, Iain Bee Huat Tan

Cell Death Dis· July 2025

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CAN-Scan: A multi-omic phenotype-driven precision oncology platform identifies prognostic biomarkers of therapy response for colorectal cancer.
Shumei Chia, Justine Jia Wen Seow, Rafael Peres da Silva, Chayaporn Suphavilai, Niranjan Shirgaonkar, Matan Thangavelu Thangavelu, Daniel Muliaditan, Emile Kwong Wei Tan, Vitoon Chinswangwatanakul, Pariyada Tanjak, Iain Beehuat Tan

Cell Rep Med· April 2025

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A deep-learning model for quantifying circulating tumour DNA from the density distribution of DNA-fragment lengths.
Guanhua Zhu, Chowdhury Rafeed Rahman, Victor Getty, Denis Odinokov, Probhonjon Baruah, Tira J Tan, Patrick Tan, Daniel Tan, Iain Beehuat Tan

Nat Biomed Eng· March 2025

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Expert consensus on the optimal management of BRAF-mutant metastatic colorectal cancer in the Asia-Pacific region.
Oliver Piercey, Lorraine Chantrill, Hung-Chih Hsu, Brigette Ma, Timothy Price, Iain Beehuat Tan

Asia Pac J Clin Oncol· February 2025

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Iron-(Fe3+)-Dependent Reactivation of Telomerase Drives Colorectal Cancers.
Raghuvaran Shanmugam, Prativa Majee, Wei Shi, Mert B Ozturk, Thamil S Vaiyapuri, Emile Tan, Chris S H Tan, Iain B Tan

Cancer Discov· October 2024

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Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response.
Yu Amanda Guo, Tanmay Kulshrestha, Mei Mei Chang, Irfahan Kassam, Egor Revkov, Aaron C Tan, Daniel S W Tan, Iain Beehuat Tan

Cancer Res Commun· June 2024

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Towards proactive palliative care in oncology: developing an explainable EHR-based machine learning model for mortality risk prediction.
Qingyuan Zhuang, Alwin Yaoxian Zhang, Ryan Shea Tan Ying Cong, Grace Meijuan Yang, Patricia Soek Hui Neo, Daniel Sw Tan, Iain Beehuat Tan

BMC Palliat Care· May 2024

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Use of Natural Language Processing to Infer Sites of Metastatic Disease From Radiology Reports at Scale.
See Boon Tay, Guat Hwa Low, Gillian Jing En Wong, Han Jieh Tey, Fun Loon Leong, Constance Li, Daniel Shao Weng Tan, Iain Bee Huat Tan, Ryan Shea Ying Cong Tan

JCO Clin Cancer Inform· May 2024

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Current advances in targeted therapy for metastatic colorectal cancer - Clinical translation and future directions.
David Johnson, Cheng Ean Chee, Wesley Wong, Rachel C T Lam, Iain Bee Huat Tan

Cancer Treat Rev· April 2024

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Bioengineered hydrogels enhance ex vivo preservation of patient-derived tumor explants for drug evaluation.
Christabella Adine, Kanishka Fernando, Nicholas Ching Wei Ho, Hong Sheng Quah, Samantha Shu Wen Ho, Daniel Shao Weng Tan, Iain Bee Huat Tan

Biomaterials· March 2024

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Functional annotation with expression validation identifies novel metastasis-relevant genes from post-GWAS risk loci in sporadic colorectal carcinomas.
Lai Fun Thean, Michelle Wong, Michelle Lo, Iain Tan, Evelyn Wong, Emile Tan, Choong Leong Tang

J Med Genet· February 2024

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The cholesterol biosynthesis enzyme FAXDC2 couples Wnt/β-catenin to RTK/MAPK signaling.
Babita Madan, Shawn R Wadia, Siddhi Patnaik, Nathan Harmston, Emile Tan, Iain Bee Huat Tan

J Clin Invest· January 2024

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COVID-19 Severity and Waning Immunity After up to 4 mRNA Vaccine Doses in 73 608 Patients With Cancer and 621 475 Matched Controls in Singapore: A Nationwide Cohort Study.
Wei Chong Tan, Janice Yu Jin Tan, Joline Si Jing Lim, Ryan Ying Cong Tan, Ainsley Ryan Yan Bin Lee, Thuan Tong Tan, Iain Beehuat Tan, Kelvin Bryan Tan

JAMA Oncol· September 2023

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Inferring cancer disease response from radiology reports using large language models with data augmentation and prompting.
Ryan Shea Ying Cong Tan, Qian Lin, Guat Hwa Low, Ruixi Lin, Tzer Chew Goh, Wei Chong Tan, Hong Qi Tan, Daniel Shao Weng Tan, Iain Bee Huat Tan

J Am Med Inform Assoc· September 2023

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DARESOME enables concurrent profiling of multiple DNA modifications with restriction enzymes in single cells and cell-free DNA.
Ramya Viswanathan, Elsie Cheruba, Pui-Mun Wong, Yao Yi, Shaun Ngang, Iain Beehuat Tan

Sci Adv· September 2023

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Polygenic risk scores for the prediction of common cancers in East Asians: A population-based prospective cohort study.
Peh Joo Ho, Iain BeeHuat Tan, Dawn Qingqing Chong, Chiea Chuen Khor, Jian-Min Yuan

Elife· March 2023

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Publisher Correction: Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors.
Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan, Kok Hao Chen, Wah Siew Tan, Iain Beehuat Tan

Nat Genet· January 2023

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Bystander CD4 T cells infiltrate human tumors and are phenotypically distinct.
Shamin Li, Summer Zhuang, Antja Heit, Si-Lin Koo, Aaron C Tan, Iain Beehuat Tan, Daniel S W Tan

Oncoimmunology· December 2022

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The distinct clinical trajectory, metastatic sites, and immunobiology of microsatellite-instability-high cancers.
Shuting Han, Aik Yong Chok, Daniel Yang Yao Peh, Joshua Zhi-Ming Ho, Emile Kwong Wei Tan, Iain Bee-Huat Tan

Front Genet· December 2022

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Heat selection enables highly scalable methylome profiling in cell-free DNA for noninvasive monitoring of cancer patients.
Elsie Cheruba, Ramya Viswanathan, Pui-Mun Wong, Howard John Womersley, Shuting Han, Iain Beehuat Tan

Sci Adv· September 2022

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A comparative study of tumour-on-chip models with patient-derived xenografts for predicting chemotherapy efficacy in colorectal cancer patients.
Louis Jun Ye Ong, Shumei Chia, Stephen Qi Rong Wong, Xiaoqian Zhang, Huiwen Chua, Emile Tan, Iain Beehuat Tan

Front Bioeng Biotechnol· August 2022

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