Publications by authors named "Ian Bathurst"

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Orally bioavailable 6-chloro-7-methoxy-4(1H)-quinolones efficacious against multiple stages of Plasmodium.
R Matthew Cross, David L Flanigan, Andrii Monastyrskyi, Alexis N LaCrue, Fabián E Sáenz, Ian Bathurst

J Med Chem· November 2014

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Ex vivo activity of endoperoxide antimalarials, including artemisone and arterolane, against multidrug-resistant Plasmodium falciparum isolates from Cambodia.
Charlotte A Lanteri, Suwanna Chaorattanakawee, Chanthap Lon, David L Saunders, Wiriya Rutvisuttinunt, Ian Bathurst

Antimicrob Agents Chemother· October 2014

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In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in Plasmodium models.
Sarah Schleiferböck, Christian Scheurer, Masataka Ihara, Isamu Itoh, Ian Bathurst

Drug Des Devel Ther· May 2014

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Discovery, synthesis, and optimization of antimalarial 4(1H)-quinolone-3-diarylethers.
Aaron Nilsen, Galen P Miley, Isaac P Forquer, Michael W Mather, Kasiram Katneni, Ian Bathurst

J Med Chem· May 2014

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Quinolone-3-diarylethers: a new class of antimalarial drug.
Aaron Nilsen, Alexis N LaCrue, Karen L White, Isaac P Forquer, Richard M Cross, Ian Bathurst

Sci Transl Med· March 2013

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In vitro and in vivo activity of solithromycin (CEM-101) against Plasmodium species.
Sergio Wittlin, Eric Ekland, J Carl Craft, Julie Lotharius, Ian Bathurst

Antimicrob Agents Chemother· February 2012

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Structure-activity relationships of 4-position diamine quinoline methanols as intermittent preventative treatment (IPT) against Plasmodium falciparum.
Erin Milner, Sean Gardner, Jay Moon, Kristina Grauer, Jennifer Auschwitz, Ian Bathurst

J Med Chem· September 2011

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Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential.
Jose M Coteron, María Marco, Jorge Esquivias, Xiaoyi Deng, Karen L White, Ian Bathurst

J Med Chem· August 2011

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Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum.
Robert H Barker, Sameer Urgaonkar, Ralph Mazitschek, Cassandra Celatka, Renato Skerlj, Ian Bathurst

Antimicrob Agents Chemother· June 2011

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Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice.
Ramesh Gujjar, Farah El Mazouni, Karen L White, John White, Sharon Creason, Ian Bathurst

J Med Chem· June 2011

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Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice.
Geoffrey S Dow, Erin Milner, Ian Bathurst, Jayendra Bhonsle, Diana Caridha

Malar J· June 2011

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Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria.
Susan A Charman, Sarah Arbe-Barnes, Ian C Bathurst, Reto Brun, Michael Campbell

Proc Natl Acad Sci U S A· March 2011

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CRIMALDDI: a co-ordinated, rational, and integrated effort to set logical priorities in anti-malarial drug discovery initiatives.
Ian C Boulton, Solomon Nwaka, Ian Bathurst, Michael Lanzer, Donatella Taramelli

Malar J· July 2010

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Chemical genetics of Plasmodium falciparum.
W Armand Guiguemde, Anang A Shelat, David Bouck, Sandra Duffy, Gregory J Crowther, Ian Bathurst

Nature· May 2010

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A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes.
Iñigo Angulo-Barturen, María Belén Jiménez-Díaz, Teresa Mulet, Joaquín Rullas, Esperanza Herreros, Ian Bathurst

PLoS One· May 2008

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Medicines for Malaria Venture: sustaining antimalarial drug development.
Ian Bathurst, Chris Hentschel

Trends Parasitol· July 2006

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