Publications by authors named "Ian D Kerr"

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Tackling Anticancer Drug Resistance and Endosomal Escape in Aggressive Brain Tumors Using Bioelectronics.
Akhil Jain, Philippa Wade, Snow Stolnik, Alistair N Hume, Ian D Kerr

ACS Omega· October 2024

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A time-resolved Förster resonance energy transfer assay to investigate drug and inhibitor binding to ABCG2.
James I Mitchell-White, Deborah A Briggs, Sarah J Mistry, Hannah A Mbiwan, Barrie Kellam, Ian D Kerr

Arch Biochem Biophys· March 2024

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Mechanistic insight into the role of AUXIN RESISTANCE4 in trafficking of AUXIN1 and LIKE AUX1-2.
Alison Tidy, Norliza Abu Bakar, David Carrier, Ian D Kerr, Charlie Hodgman

Plant Physiol· December 2023

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Extracellular Vesicles Potentiate Medulloblastoma Metastasis in an EMMPRIN and MMP-2 Dependent Manner.
Hannah K Jackson, Christine Mitoko, Franziska Linke, Donald Macarthur, Ian D Kerr

Cancers (Basel)· May 2023

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Drug Resistance in Medulloblastoma Is Driven by YB-1, ABCB1 and a Seven-Gene Drug Signature.
Louisa Taylor, Philippa K Wade, James E C Johnson, Macha Aldighieri, Sonia Morlando, Ian D Kerr

Cancers (Basel)· February 2023

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Identifying new biomarkers of aggressive Group 3 and SHH medulloblastoma using 3D hydrogel models, single cell RNA sequencing and 3D OrbiSIMS imaging.
Franziska Linke, James E C Johnson, Stefanie Kern, Christopher D Bennett, Anbarasu Lourdusamy, Ian D Kerr

Acta Neuropathol Commun· January 2023

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Vinca alkaloid binding to P-glycoprotein occurs in a processive manner.
Shagufta Iqbal, Caitlin Flux, Deborah A Briggs, Evelyne Deplazes, Jiansi Long, Ian D Kerr

Biochim Biophys Acta Biomembr· October 2022

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Detergent-Free Membrane Protein Purification Using SMA Polymer.
Luke Broadbent, Peer Depping, Alexis Lodé, Afroditi Vaitsopoulou, David Hardy, Ian D Kerr

Methods Mol Biol· July 2022

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Corrigendum to: ABCB1 inhibition provides a novel therapeutic target to block TWIST1-induced migration in medulloblastoma.
Aishah Nasir, Alice Cardall, Ramadhan T Othman, Niovi Nicolaou, Anbarasu Lourdusamy, Ian D Kerr

Neurooncol Adv· December 2021

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Function of the pseudo phosphotransfer proteins has diverged between rice and Arabidopsis.
John Vaughan-Hirsch, Emily J Tallerday, Christian A Burr, Charlie Hodgens, Samantha L Boeshore, Ian D Kerr

Plant J· April 2021

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BLBP Is Both a Marker for Poor Prognosis and a Potential Therapeutic Target in Paediatric Ependymoma.
Durgagauri H Sabnis, Jo-Fen Liu, Lucy Simmonds, Sophie Blackburn, Richard G Grundy, Ian D Kerr

Cancers (Basel)· April 2021

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ABCB1 inhibition provides a novel therapeutic target to block TWIST1-induced migration in medulloblastoma.
Aishah Nasir, Alice Cardall, Ramadhan T Othman, Niovi Nicolaou, Anbarasu Lourdusamy, Ian D Kerr

Neurooncol Adv· April 2021

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3D hydrogels reveal medulloblastoma subgroup differences and identify extracellular matrix subtypes that predict patient outcome.
Franziska Linke, Macha Aldighieri, Anbarasu Lourdusamy, Anna M Grabowska, Snow Stolnik, Ian D Kerr

J Pathol· March 2021

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Y-Box Binding Protein-1: A Neglected Target in Pediatric Brain Tumors?
Louisa Taylor, Ian D Kerr, Beth Coyle

Mol Cancer Res· March 2021

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Mammalian ABCG-transporters, sterols and lipids: To bind perchance to transport?
Ian D Kerr, Ella Hutchison, Louise Gerard, Shereen M Aleidi, Ingrid C Gelissen

Biochim Biophys Acta Mol Cell Biol Lipids· March 2021

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Analysis of Sequence Divergence in Mammalian ABCGs Predicts a Structural Network of Residues That Underlies Functional Divergence.
James I Mitchell-White, Thomas Stockner, Nicholas Holliday, Stephen J Briddon, Ian D Kerr

Int J Mol Sci· March 2021

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Picky ABCG5/G8 and promiscuous ABCG2 - a tale of fatty diets and drug toxicity.
Narakorn Khunweeraphong, James Mitchell-White, Dániel Szöllősi, Toka Hussein, Karl Kuchler, Ian D Kerr

FEBS Lett· December 2020

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Cross-linking, DEER-spectroscopy and molecular dynamics confirm the inward facing state of P-glycoprotein in a lipid membrane.
Alex R Carey Hulyer, Deborah A Briggs, Megan L O'Mara, Ian D Kerr, Jeffrey R Harmer

J Struct Biol· July 2020

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Application of fluorescence correlation spectroscopy to study substrate binding in styrene maleic acid lipid copolymer encapsulated ABCG2.
Aaron J Horsey, Deborah A Briggs, Nicholas D Holliday, Stephen J Briddon, Ian D Kerr

Biochim Biophys Acta Biomembr· June 2020

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Disruption of the Unique ABCG-Family NBD:NBD Interface Impacts Both Drug Transport and ATP Hydrolysis.
Parth Kapoor, Deborah A Briggs, Megan H Cox, Ian D Kerr

Int J Mol Sci· January 2020

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A role for ABCB1 in prognosis, invasion and drug resistance in ependymoma.
Durgagauri H Sabnis, Lisa C D Storer, Jo-Fen Liu, Hannah K Jackson, J P Kilday, Ian D Kerr

Sci Rep· July 2019

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Polymorphisms of the Multidrug Pump ABCG2: A Systematic Review of Their Effect on Protein Expression, Function, and Drug Pharmacokinetics.
Niall Heyes, Parth Kapoor, Ian D Kerr

Drug Metab Dispos· December 2018

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ABCG2: does resolving its structure elucidate the mechanism?
Parth Kapoor, Aaron J Horsey, Megan H Cox, Ian D Kerr

Biochem Soc Trans· December 2018

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Residues contributing to drug transport by ABCG2 are localised to multiple drug-binding pockets.
Megan H Cox, Parth Kapoor, Deborah A Briggs, Ian D Kerr

Biochem J· May 2018

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Location of contact residues in pharmacologically distinct drug binding sites on P-glycoprotein.
Rituparna Mittra, Megan Pavy, Nanditha Subramanian, Anthony M George, Megan L O'Mara, Ian D Kerr

Biochem Pharmacol· January 2017

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