Publications by authors named "Nicholas D Holliday"

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An industrial perspective on ligand bias in GPCR drug discovery.
James P Farmer, James E Mason, Nicholas D Holliday, Stephen J Briddon, Leigh A Stoddart

Neuropharmacology· February 2026

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GRK-biased adrenergic agonists for the treatment of type 2 diabetes and obesity.
Aikaterini Motso, Benjamin Pelcman, Anastasia Kalinovich, Nour Aldin Kahlous, Muhammad Hamza Bokhari, Nicholas D Holliday

Cell· September 2025

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GRK-biased adrenergic agonists for the treatment of type 2 diabetes and obesity.
Aikaterini Motso, Benjamin Pelcman, Anastasia Kalinovich, Nour Aldin Kahlous, Muhammad Hamza Bokhari, Nicholas D Holliday

Cell· September 2025

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Dually Labeled Neurotensin NTSR Ligands for Probing Radiochemical and Fluorescence-Based Binding Assays.
Fabian J Ertl, Sergei Kopanchuk, Nicola C Dijon, Santa Veikšina, Maris-Johanna Tahk, Nicholas D Holliday

J Med Chem· September 2024

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The novel adrenergic agonist ATR-127 targets skeletal muscle and brown adipose tissue to tackle diabesity and steatohepatitis.
Emanuela Talamonti, Jelena Davegardh, Anastasia Kalinovich, Sten M M van Beek, Nodi Dehvari, Nicholas D Holliday

Mol Metab· July 2024

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High-throughput kinetics in drug discovery.
Maria Filipa Pinto, Julija Sirina, Nicholas D Holliday, Claire L McWhirter

SLAS Discov· July 2024

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A time-resolved Förster resonance energy transfer assay to investigate drug and inhibitor binding to ABCG2.
James I Mitchell-White, Deborah A Briggs, Sarah J Mistry, Hannah A Mbiwan, Barrie Kellam, Nicholas D Holliday

Arch Biochem Biophys· March 2024

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Role of G protein-coupled receptor kinases (GRKs) in β -adrenoceptor-mediated glucose uptake.
Seungmin Ham, Saori Mukaida, Masaaki Sato, Peter Keov, Tore Bengtsson, Nicholas D Holliday

Pharmacol Res Perspect· February 2024

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ThermoBRET: A Ligand-Engagement Nanoscale Thermostability Assay Applied to GPCRs.
Bradley L Hoare, David N Tippett, Amandeep Kaur, Sean A Cullum, Tamara Miljuš, Nicholas D Holliday

Chembiochem· January 2024

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The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors.
Stephen P H Alexander, Arthur Christopoulos, Anthony P Davenport, Eamonn Kelly, Alistair A Mathie, Nicholas D Holliday

Br J Pharmacol· October 2023

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Design, Synthesis, and Application of Fluorescent Ligands Targeting the Intracellular Allosteric Binding Site of the CXC Chemokine Receptor 2.
Bianca Maria Casella, James P Farmer, Desislava N Nesheva, Huw E L Williams, Steven J Charlton, Nicholas D Holliday

J Med Chem· September 2023

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Correction to "Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta".
Martin L Stockley, Giovanni Benedetti, Peter Blencowe, Simon J Boulton, Susan M Boyd, Nicholas D Holliday

J Med Chem· February 2023

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Bitter taste sensitivity in domestic dogs (Canis familiaris) and its relevance to bitter deterrents of ingestion.
Matthew Gibbs, Marcel Winnig, Irene Riva, Nicola Dunlop, Daniel Waller, Nicholas D Holliday

PLoS One· December 2022

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Development of fluorescent peptide G protein-coupled receptor activation biosensors for NanoBRET characterization of intracellular allosteric modulators.
James P Farmer, Shailesh N Mistry, Charles A Laughton, Nicholas D Holliday

FASEB J· November 2022

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Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta.
Martin L Stockley, Amanda Ferdinand, Giovanni Benedetti, Peter Blencowe, Susan M Boyd, Nicholas D Holliday

J Med Chem· October 2022

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Optical control of the β-adrenergic receptor with opto-prop-2: A -active azobenzene analog of propranolol.
Reggie Bosma, Nicola C Dijon, Yang Zheng, Hannes Schihada, Niels J Hauwert, Nicholas D Holliday

iScience· September 2022

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THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors.
Stephen Ph Alexander, Arthur Christopoulos, Anthony P Davenport, Eamonn Kelly, Alistair Mathie, Nicholas D Holliday

Br J Pharmacol· October 2021

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Luciferase Complementation Approaches to Measure GPCR Signaling Kinetics and Bias.
Nicola C Dijon, Desislava N Nesheva, Nicholas D Holliday

Methods Mol Biol· July 2021

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The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex.
Chek Ziu Koo, Neale Harrison, Peter J Noy, Justyna Szyroka, Alexandra L Matthews, Nicholas D Holliday

J Biol Chem· September 2020

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Application of fluorescence correlation spectroscopy to study substrate binding in styrene maleic acid lipid copolymer encapsulated ABCG2.
Aaron J Horsey, Deborah A Briggs, Nicholas D Holliday, Stephen J Briddon, Ian D Kerr

Biochim Biophys Acta Biomembr· June 2020

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Heterodimeric Analogues of the Potent Y1R Antagonist 1229U91, Lacking One of the Pharmacophoric C-Terminal Structures, Retain Potent Y1R Affinity and Show Improved Selectivity over Y4R.
Rachel R Richardson, Marleen Groenen, Mengjie Liu, Simon J Mountford, Stephen J Briddon, Nicholas D Holliday

J Med Chem· May 2020

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Red-Emitting Dibenzodiazepinone Derivatives as Fluorescent Dualsteric Probes for the Muscarinic Acetylcholine M Receptor.
Xueke She, Andrea Pegoli, Corinna G Gruber, David Wifling, Jessica Carpenter, Nicholas D Holliday

J Med Chem· April 2020

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Fluorescence Labeling of Neurotensin(8-13) via Arginine Residues Gives Molecular Tools with High Receptor Affinity.
Max Keller, Shahani A Mahuroof, Vivyanne Hong Yee, Jessica Carpenter, Lisa Schindler, Nicholas D Holliday

ACS Med Chem Lett· January 2020

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The Peptide PnPP-19, a Spider Toxin Derivative, Activates μ-Opioid Receptors and Modulates Calcium Channels.
Ana C N Freitas, Steve Peigneur, Flávio H P Macedo, José E Menezes-Filho, Paul Millns, Nicholas D Holliday

Toxins (Basel)· January 2018

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Identification of a Cyanine-Dye Labeled Peptidic Ligand for Y1R and Y4R, Based upon the Neuropeptide Y C-Terminal Analogue, BVD-15.
Mengjie Liu, Rachel R Richardson, Simon J Mountford, Lei Zhang, Matheus H Tempone, Nicholas D Holliday

Bioconjug Chem· September 2016

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