Publications by authors named "Ian Foltz"

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Assessing Functional Similarity of Biosimilar ABP 654 and Ustekinumab in Samples from Patients with Crohn's Disease.
Ian N Foltz, Kevin Gaida, Helen Y Wong, Michael Ng, Marijana Busch

J Inflamm Res· December 2024

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Analytical and Functional Similarity of Aflibercept Biosimilar ABP 938 with Aflibercept Reference Product.
Neungseon Seo, Xiaoyan Guan, Tian Wang, Hyo S Helen Chung, Mats Wikström, Ian N Foltz

Ophthalmol Ther· May 2024

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Native SEC and Reversed-Phase LC-MS Reveal Impact of Fab Glycosylation of Anti-SARS-COV-2 Antibodies on Binding to the Receptor Binding Domain.
Daniel W Woodall, Christy A Thomson, Thomas M Dillon, Arnold McAuley, Lydia B Green, Ian N Foltz

Anal Chem· October 2023

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Development of a potent high-affinity human therapeutic antibody via novel application of recombination signal sequence-based affinity maturation.
Agnieszka Kielczewska, Igor D'Angelo, Maria Sheena Amador, Tina Wang, Athena Sudom, Ian N Foltz

J Biol Chem· February 2022

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Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer's disease.
Daniel C Ellwanger, Shoutang Wang, Simone Brioschi, Zhifei Shao, Lydia Green, Ian N Foltz

Proc Natl Acad Sci U S A· January 2021

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The serum protein transthyretin as a platform for dimerization and tetramerization of antibodies and Fab fragments to enable target clustering.
Kenneth W Walker, Ian N Foltz, Tina Wang, Hossein Salimi-Moosavi, Julie M Bailis

J Biol Chem· July 2020

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Functional and Nonclinical Similarity of ABP 980, a Biosimilar of Trastuzumab.
Shea Jassem, Wei Wang, Heather Sweet, Raffi Manoukian, Vincent Chow, Ian N Foltz

Pharm Res· November 2019

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Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models.
Elizabeth A Killion, Jinghong Wang, Junming Yie, Stone D-H Shi, Darren Bates, Ian N Foltz

Sci Transl Med· December 2018

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TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant on murine myeloid cell function.
Qingwen Cheng, Jean Danao, Santosh Talreja, Paul Wen, Jun Yin, Ian N Foltz

J Biol Chem· August 2018

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Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2.
Athena Sudom, Santosh Talreja, Jean Danao, Eric Bragg, Rob Kegel, Ian N Foltz

J Biol Chem· August 2018

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Impact of antibody subclass and disulfide isoform differences on the biological activity of CD200R and βklotho agonist antibodies.
Ognjen Grujic, Jennitte Stevens, Robert Y-T Chou, Jennifer V Weiszmann, Laura Sekirov, Ian N Foltz

Biochem Biophys Res Commun· May 2017

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Discovery and bio-optimization of human antibody therapeutics using the XenoMouse® transgenic mouse platform.
Ian N Foltz, Kannan Gunasekaran, Chadwick T King

Immunol Rev· March 2016

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Identification and Characterization of MEDI4736, an Antagonistic Anti-PD-L1 Monoclonal Antibody.
Ross Stewart, Michelle Morrow, Scott A Hammond, Kathy Mulgrew, Danielle Marcus, Ian N Foltz

Cancer Immunol Res· September 2015

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AMG 595, an Anti-EGFRvIII Antibody-Drug Conjugate, Induces Potent Antitumor Activity against EGFRvIII-Expressing Glioblastoma.
Kevin J Hamblett, Carl J Kozlosky, Sophia Siu, Wesley S Chang, Hua Liu, Ian N Foltz

Mol Cancer Ther· July 2015

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A novel antibody engineering strategy for making monovalent bispecific heterodimeric IgG antibodies by electrostatic steering mechanism.
Zhi Liu, Esther C Leng, Kannan Gunasekaran, Martin Pentony, Min Shen, Ian N Foltz

J Biol Chem· March 2015

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Apo2L/TRAIL and the death receptor 5 agonist antibody AMG 655 cooperate to promote receptor clustering and antitumor activity.
Jonathan D Graves, Jennifer J Kordich, Tzu-Hsuan Huang, Julia Piasecki, Tammy L Bush, Ian N Foltz

Cancer Cell· August 2014

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Asymmetrical Fc engineering greatly enhances antibody-dependent cellular cytotoxicity (ADCC) effector function and stability of the modified antibodies.
Zhi Liu, Kannan Gunasekaran, Wei Wang, Vladimir Razinkov, Laura Sekirov, Ian Foltz

J Biol Chem· February 2014

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A fully human anti-hepcidin antibody modulates iron metabolism in both mice and nonhuman primates.
Keegan S Cooke, Beth Hinkle, Hossein Salimi-Moosavi, Ian Foltz, Chadwick King

Blood· October 2013

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Evolution and emergence of therapeutic monoclonal antibodies: what cardiologists need to know.
Ian N Foltz, Margaret Karow, Scott M Wasserman

Circulation· June 2013

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Treating diabetes and obesity with an FGF21-mimetic antibody activating the βKlotho/FGFR1c receptor complex.
Ian N Foltz, Sylvia Hu, Chadwick King, Xinle Wu, Chaofeng Yang

Sci Transl Med· November 2012

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MEDI0639: a novel therapeutic antibody targeting Dll4 modulates endothelial cell function and angiogenesis in vivo.
David W Jenkins, Sarah Ross, Margaret Veldman-Jones, Ian N Foltz, Brandon C Clavette

Mol Cancer Ther· August 2012

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Molecular mechanism of hepcidin-mediated ferroportin internalization requires ferroportin lysines, not tyrosines or JAK-STAT.
Sandra L Ross, Lynn Tran, Aaron Winters, Ki-Jeong Lee, Cherylene Plewa, Ian Foltz

Cell Metab· June 2012

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Kinetic analysis of unpurified native antigens available in very low quantities and concentrations.
Palaniswami Rathanaswami, Karen Richmond, Kathy Manchulenko, Ian N Foltz

Anal Biochem· July 2011

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An antibody targeted to VEGFR-2 Ig domains 4-7 inhibits VEGFR-2 activation and VEGFR-2-dependent angiogenesis without affecting ligand binding.
Jane Kendrew, Cath Eberlein, Brad Hedberg, Karen McDaid, Neil R Smith, Ian Foltz

Mol Cancer Ther· May 2011

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Enhancing antibody Fc heterodimer formation through electrostatic steering effects: applications to bispecific molecules and monovalent IgG.
Kannan Gunasekaran, Martin Pentony, Min Shen, Logan Garrett, Carla Forte, Ian N Foltz

J Biol Chem· June 2010

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