Publications by authors named "Ian Nessler"

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Increased imaging ligand hydrophilicity and improved pharmacokinetic properties provides enhanced in vivo targeting of fibroblast activation protein.
Radhika Narain, Ian Nessler, Paul L Richardson, Jamie E Erickson, Yuzhen Wang

Npj Imaging· August 2024

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Improving Intracellular Delivery of an Antibody-Drug Conjugate Targeting Carcinoembryonic Antigen Increases Efficacy at Clinically Relevant Doses In Vivo.
Ian Nessler, Baron Rubahamya, Anna Kopp, Scott Hofsess, Thomas M Cardillo

Mol Cancer Ther· March 2024

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Predictive Simulations in Preclinical Oncology to Guide the Translation of Biologics.
Shujun Dong, Ian Nessler, Anna Kopp, Baron Rubahamya, Greg M Thurber

Front Pharmacol· March 2022

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Key metrics to expanding the pipeline of successful antibody-drug conjugates.
Ian Nessler, Bruna Menezes, Greg M Thurber

Trends Pharmacol Sci· October 2021

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Quantifying ADC bystander payload penetration with cellular resolution using pharmacodynamic mapping.
Eshita Khera, Cornelius Cilliers, Michael D Smith, Michelle L Ganno, Katharine C Lai, Ian Nessler

Neoplasia· February 2021

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Increased Tumor Penetration of Single-Domain Antibody-Drug Conjugates Improves Efficacy in Prostate Cancer Models.
Ian Nessler, Eshita Khera, Steven Vance, Anna Kopp, Qifeng Qiu

Cancer Res· March 2020

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Practical Guide for Quantification of In Vivo Degradation Rates for Therapeutic Proteins with Single-Cell Resolution Using Fluorescence Ratio Imaging.
Ian Nessler, Cornelius Cilliers, Greg M Thurber

Pharmaceutics· February 2020

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Blocking of Glucagonlike Peptide-1 Receptors in the Exocrine Pancreas Improves Specificity for β-Cells in a Mouse Model of Type 1 Diabetes.
Eshita Khera, Liang Zhang, Sheryl Roberts, Ian Nessler, Darleen Sandoval

J Nucl Med· November 2019

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Quantitative pharmacology in antibody-drug conjugate development: armed antibodies or targeted small molecules?
Ian Nessler, Eshita Khera, Greg M Thurber

Oncoscience· May 2018

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Improved Tumor Penetration and Single-Cell Targeting of Antibody-Drug Conjugates Increases Anticancer Efficacy and Host Survival.
Cornelius Cilliers, Bruna Menezes, Ian Nessler, Jennifer Linderman, Greg M Thurber

Cancer Res· February 2018

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Tracking Antibody Distribution with Near-Infrared Fluorescent Dyes: Impact of Dye Structure and Degree of Labeling on Plasma Clearance.
Cornelius Cilliers, Ian Nessler, Nikolas Christodolu, Greg M Thurber

Mol Pharm· May 2017

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Toward polarizable AMOEBA thermodynamics at fixed charge efficiency using a dual force field approach: application to organic crystals.
Ian J Nessler, Jacob M Litman, Michael J Schnieders

Phys Chem Chem Phys· November 2016

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Absolute Organic Crystal Thermodynamics: Growth of the Asymmetric Unit into a Crystal via Alchemy.
Jooyeon Park, Ian Nessler, Brian McClain, Dainius Macikenas, Jonas Baltrusaitis

J Chem Theory Comput· July 2014

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