Publications by authors named "Idit Shachar"

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The immune receptor SLAMF5 regulates myeloid-cell mediated neuroinflammation in multiple sclerosis.
Laura Bellassen, Keren David, Bar Lampert, Avital Sarusi-Portuguez, Michael Tsoory, Idit Shachar

PLoS Biol· September 2025

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CD84 as a therapeutic target for breaking immune tolerance in triple-negative breast cancer.
Stav Rabani, Emine Gulsen Gunes, Martin Gunes, Bianca Pellegrino, Bar Lampert, Idit Shachar

Cell Rep· November 2024

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CD74 promotes the formation of an immunosuppressive tumor microenvironment in triple-negative breast cancer in mice by inducing the expansion of tolerogenic dendritic cells and regulatory B cells.
Bianca Pellegrino, Keren David, Stav Rabani, Bar Lampert, Thuy Tran, Idit Shachar

PLoS Biol· November 2024

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Signaling lymphocytic activation molecule family receptors as potential immune therapeutic targets in solid tumors.
Metin Gunes, Steven T Rosen, Idit Shachar, E Gulsen Gunes

Front Immunol· March 2024

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CD84 is a regulator of the immunosuppressive microenvironment in multiple myeloma.
Hadas Lewinsky, Emine G Gunes, Keren David, Lihi Radomir, Matthias P Kramer, Idit Shachar

JCI Insight· July 2023

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Sulfamate Acetamides as Self-Immolative Electrophiles for Covalent Ligand-Directed Release Chemistry.
Rambabu N Reddi, Adi Rogel, Ronen Gabizon, Dattatraya Gautam Rawale, Battu Harish, Idit Shachar

J Am Chem Soc· February 2023

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CXCR4 and CD74 together enhance cell survival in response to macrophage migration-inhibitory factor in chronic lymphocytic leukemia.
Tharshika Thavayogarajah, Dzmitry Sinitski, Omar El Bounkari, Laura Torres-Garcia, Hadas Lewinsky, Idit Shachar

Exp Hematol· November 2022

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CD74 as a regulator of transcription in normal B cells.
Keren David, Gilgi Friedlander, Bianca Pellegrino, Lihi Radomir, Hadas Lewinsky, Idit Shachar

Cell Rep· November 2022

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Polysome-CAGE of TCL1-driven chronic lymphocytic leukemia revealed multiple N-terminally altered epigenetic regulators and a translation stress signature.
Ariel Ogran, Tal Havkin-Solomon, Shirly Becker-Herman, Keren David, Idit Shachar

Elife· August 2022

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CD74 is a regulator of hematopoietic stem cell maintenance.
Shirly Becker-Herman, Milena Rozenberg, Carmit Hillel-Karniel, Naama Gil-Yarom, Mattias P Kramer, Idit Shachar

PLoS Biol· March 2021

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The survival and function of IL-10-producing regulatory B cells are negatively controlled by SLAMF5.
Lihi Radomir, Matthias P Kramer, Michal Perpinial, Nofar Schottlender, Stav Rabani, Idit Shachar

Nat Commun· March 2021

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CD84 is a regulator of the immunosuppressive microenvironment in multiple myeloma.
Hadas Lewinsky, Emine G Gunes, Keren David, Lihi Radomir, Matthias P Kramer, Idit Shachar

JCI Insight· February 2021

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Transcription Dynamics Regulate Poly(A) Tails and Expression of the RNA Degradation Machinery to Balance mRNA Levels.
Boris Slobodin, Anat Bahat, Urmila Sehrawat, Shirly Becker-Herman, Binyamin Zuckerman, Idit Shachar

Mol Cell· May 2020

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Bone marrow dendritic cells support the survival of chronic lymphocytic leukemia cells in a CD84 dependent manner.
Avital F Barak, Hadas Lewinsky, Michal Perpinial, Victoria Huber, Lihi Radomir, Idit Shachar

Oncogene· February 2020

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Golgi organization is regulated by proteasomal degradation.
Avital Eisenberg-Lerner, Ron Benyair, Noa Hizkiahou, Neta Nudel, Roey Maor, Idit Shachar

Nat Commun· January 2020

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Circulating Picomolar Levels of CCL2 Downregulate Ongoing Chronic Experimental Autoimmune Encephalomyelitis by Induction of Regulatory Mechanisms.
Nathali Kaushansky, Eszter Bakos, Shirly Becker-Herman, Idit Shachar, Avraham Ben-Nun

J Immunol· October 2019

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SLAMF9 regulates pDC homeostasis and function in health and disease.
Lital Sever, Lihi Radomir, Kristin Stirm, Anna Wiener, Nofar Schottlender, Idit Shachar

Proc Natl Acad Sci U S A· August 2019

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SLAMF receptors on normal and malignant B cells.
Idit Shachar, Avital Barak, Hadas Lewinsky, Lital Sever, Lihi Radomir

Clin Immunol· July 2019

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CD84 regulates PD-1/PD-L1 expression and function in chronic lymphocytic leukemia.
Hadas Lewinsky, Avital F Barak, Victoria Huber, Matthias P Kramer, Lihi Radomir, Idit Shachar

J Clin Invest· December 2018

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A phase I-II clinical trial of the anti-CD74 monoclonal antibody milatuzumab in frail patients with refractory chronic lymphocytic leukaemia: A patient based approach.
Michal Haran, Vita Mirkin, Andrei Braester, Nurith Harpaz, Olga Shevetz, Idit Shachar

Br J Haematol· July 2018

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LPS-mediated cell surface expression of CD74 promotes the proliferation of B cells in response to MIF.
Christina Klasen, Tamar Ziehm, Michael Huber, Yaw Asare, Aphrodite Kapurniotu, Idit Shachar

Cell Signal· June 2018

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An essential MIF-CD74 signaling axis in kidney tubular regeneration, with prospects for precision medicine and pharmacological augmentation.
Idit Shachar

Am J Physiol Renal Physiol· November 2017

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T Cells Regulate Peripheral Naive Mature B Cell Survival by Cell-Cell Contact Mediated through SLAMF6 and SAP.
Lihi Radomir, Sivan Cohen, Matthias P Kramer, Eszter Bakos, Hadas Lewinsky, Idit Shachar

J Immunol· October 2017

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CCR2 Regulates the Immune Response by Modulating the Interconversion and Function of Effector and Regulatory T Cells.
Eszter Bakos, Christoph A Thaiss, Matthias P Kramer, Sivan Cohen, Lihi Radomir, Idit Shachar

J Immunol· June 2017

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CD74 is a novel transcription regulator.
Naama Gil-Yarom, Lihi Radomir, Lital Sever, Matthias P Kramer, Hadas Lewinsky, Idit Shachar

Proc Natl Acad Sci U S A· January 2017

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