Publications by authors named "Ingo Flamme"

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Pharmacodynamic effects of molidustat on erythropoiesis in healthy cats.
Annette Boegel, Ingo Flamme, Ralph Krebber, Terry Settje, Franziska Schmidt

J Vet Intern Med· February 2024

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Rational design of highly stabilized and selective adrenomedullin analogs.
Eva-Maria Jülke, Jan-Patrick Fischer, Sylvia Els-Heindl, Donald Bierer, Ingo Flamme

J Pept Sci· December 2023

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Discovery of Molidustat (BAY 85-3934): A Small-Molecule Oral HIF-Prolyl Hydroxylase (HIF-PH) Inhibitor for the Treatment of Renal Anemia.
Hartmut Beck, Mario Jeske, Kai Thede, Friederike Stoll, Ingo Flamme

ChemMedChem· May 2018

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FGF23 expression in rodents is directly induced via erythropoietin after inhibition of hypoxia inducible factor proline hydroxylase.
Ingo Flamme, Peter Ellinghaus, Diana Urrego, Thilo Krüger

PLoS One· November 2017

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Mimicking hypoxia to treat anemia: HIF-stabilizer BAY 85-3934 (Molidustat) stimulates erythropoietin production without hypertensive effects.
Ingo Flamme, Felix Oehme, Peter Ellinghaus, Mario Jeske, Jörg Keldenich

PLoS One· January 2016

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PHD4 stimulates tumor angiogenesis in osteosarcoma cells via TGF-α.
Anne Klotzsche-von Ameln, Ina Prade, Marianne Grosser, Antje Kettelhake, Maryam Rezaei, Ingo Flamme

Mol Cancer Res· November 2013

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BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I.
Peter Ellinghaus, Iring Heisler, Kerstin Unterschemmann, Michael Haerter, Hartmut Beck, Ingo Flamme

Cancer Med· October 2013

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Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors.
Shohei Hamada, Takayoshi Suzuki, Koshiki Mino, Koichi Koseki, Felix Oehme, Ingo Flamme

J Med Chem· August 2010

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Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors.
Anne-Theres Henze, Johanna Riedel, Tanja Diem, Julia Wenner, Ingo Flamme

Cancer Res· January 2010

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The impact of N-nitrosomelatonin as nitric oxide donor in cell culture experiments.
Utta Berchner-Pfannschmidt, Suzan Tug, Buena Trinidad, Maria Becker, Felix Oehme, Ingo Flamme

J Pineal Res· November 2008

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Nuclear oxygen sensing: induction of endogenous prolyl-hydroxylase 2 activity by hypoxia and nitric oxide.
Utta Berchner-Pfannschmidt, Suzan Tug, Buena Trinidad, Felix Oehme, Hatice Yamac, Ingo Flamme

J Biol Chem· November 2008

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Determination and modulation of prolyl-4-hydroxylase domain oxygen sensor activity.
Renato Wirthner, Kuppusamy Balamurugan, Daniel P Stiehl, Sandra Barth, Patrick Spielmann, Ingo Flamme

Methods Enzymol· February 2008

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Inhibition of hypoxia-inducible factor activity in endothelial cells disrupts embryonic cardiovascular development.
Alexander H Licht, Felix Müller-Holtkamp, Ingo Flamme, Georg Breier

Blood· January 2006

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Genetic evidence for a tumor suppressor role of HIF-2alpha.
Till Acker, Antonio Diez-Juan, Julian Aragones, Marc Tjwa, Koen Brusselmans, Ingo Flamme

Cancer Cell· August 2005

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Copper-dependent activation of hypoxia-inducible factor (HIF)-1: implications for ceruloplasmin regulation.
Falk Martin, Tobias Linden, Dörthe M Katschinski, Felix Oehme, Ingo Flamme

Blood· June 2005

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A nonradioactive 96-well plate assay for the detection of hypoxia-inducible factor prolyl hydroxylase activity.
Felix Oehme, Willi Jonghaus, Laila Narouz-Ott, Joachim Huetter, Ingo Flamme

Anal Biochem· July 2004

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Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1).
Gerd Elvert, Andreas Kappel, Regina Heidenreich, Ursula Englmeier, Stephan Lanz, Ingo Flamme

J Biol Chem· February 2003

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Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors.
Felix Oehme, Peter Ellinghaus, Peter Kolkhof, Timothy J Smith, Shyam Ramakrishnan, Ingo Flamme

Biochem Biophys Res Commun· August 2002

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