Publications by authors named "Inmaculada Villar"

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Current practices on the measurement of electrocardiogram and hemodynamic parameters in non-rodent species in regulatory safety assessment studies.
Jean-Pierre Valentin, Todd Bourcier, Xuan Chi, Annie Delaunois, C Michael Foley, Inmaculada C Villar

J Pharmacol Toxicol Methods· September 2025

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Modelling hemodynamics regulation in rats and dogs to facilitate drugs safety risk assessment.
Christopher J Morris, Michael G Rolf, Linda Starnes, Inmaculada C Villar, Amy Pointon

Front Pharmacol· October 2024

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Identification of Novel Series of Potent and Selective Relaxin Family Peptide Receptor 1 (RXFP1) Agonists.
Kenneth L Granberg, Shigeki Sakamaki, Ryuichi Fuchigami, Yasuki Niwa, Masakazu Fujio, Inmaculada C Villar

J Med Chem· March 2024

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Discovery of Clinical Candidate AZD5462, a Selective Oral Allosteric RXFP1 Agonist for Treatment of Heart Failure.
Kenneth L Granberg, Shigeki Sakamaki, Niklas Larsson, Fredrik Bergström, Ryuichi Fuchigami, Inmaculada C Villar

J Med Chem· March 2024

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Characterisation of preproendothelin-1 derived peptides identifies Endothelin-Like Domain Peptide as a modulator of Endothelin-1.
Jale Yuzugulen, Julie A Douthwaite, Elizabeth G Wood, Inmaculada C Villar, Nimesh S A Patel

Sci Rep· July 2017

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Functional pharmacological characterization of SER100 in cardiovascular health and disease.
Inmaculada C Villar, Kristen J Bubb, Amie J Moyes, Eva Steiness, Trygve Gulbrandsen

Br J Pharmacol· December 2016

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Endothelial C-type natriuretic peptide maintains vascular homeostasis.
Amie J Moyes, Rayomand S Khambata, Inmaculada Villar, Kristen J Bubb, Reshma S Baliga

J Clin Invest· September 2014

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Distinct endothelial pathways underlie sexual dimorphism in vascular auto-regulation.
Melissa V Chan, Kristen J Bubb, Alastair Noyce, Inmaculada C Villar, Johan Duchene

Br J Pharmacol· October 2012

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Suppression of endothelial P-selectin expression contributes to reduced cell trafficking in females: an effect independent of NO and prostacyclin.
Inmaculada C Villar, Ramona S Scotland, Rayomand S Khambata, Melissa Chan, Johan Duchene

Arterioscler Thromb Vasc Biol· May 2011

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Sex differences in vascular function: implication of endothelium-derived hyperpolarizing factor.
Inmaculada C Villar, Adrian J Hobbs, Amrita Ahluwalia

J Endocrinol· June 2008

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Definitive role for natriuretic peptide receptor-C in mediating the vasorelaxant activity of C-type natriuretic peptide and endothelium-derived hyperpolarising factor.
Inmaculada C Villar, Catherine M Panayiotou, Adil Sheraz, Melanie Madhani, Ramona S Scotland

Cardiovasc Res· June 2007

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Quercetin and isorhamnetin prevent endothelial dysfunction, superoxide production, and overexpression of p47phox induced by angiotensin II in rat aorta.
Manuel Sanchez, Federica Lodi, Rocio Vera, Inmaculada C Villar, Angel Cogolludo

J Nutr· April 2007

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Chronic administration of genistein improves endothelial dysfunction in spontaneously hypertensive rats: involvement of eNOS, caveolin and calmodulin expression and NADPH oxidase activity.
Rocio Vera, Manuel Sánchez, Milagros Galisteo, Inmaculada Concepcion Villar, Rosario Jimenez

Clin Sci (Lond)· February 2007

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Quercetin downregulates NADPH oxidase, increases eNOS activity and prevents endothelial dysfunction in spontaneously hypertensive rats.
Manuel Sánchez, Milagros Galisteo, Rocío Vera, Inmaculada C Villar, Antonio Zarzuelo

J Hypertens· January 2006

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Soy isoflavones improve endothelial function in spontaneously hypertensive rats in an estrogen-independent manner: role of nitric-oxide synthase, superoxide, and cyclooxygenase metabolites.
Rocío Vera, Milagros Galisteo, Inmaculada Concepción Villar, Manuel Sánchez, Antonio Zarzuelo

J Pharmacol Exp Ther· September 2005

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Endothelial nitric oxide production stimulated by the bioflavonoid chrysin in rat isolated aorta.
Inmaculada Concepción Villar, Rocío Vera, Milagros Galisteo, Francisco O'Valle, Miguel Romero

Planta Med· September 2005

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Effects of chronic quercetin treatment in experimental renovascular hypertension.
María Francisca García-Saura, Milagros Galisteo, Inmaculada Concepción Villar, Almudena Bermejo, Antonio Zarzuelo

Mol Cell Biochem· February 2005

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Effects of the dietary flavonoid chrysin in isolated rat mesenteric vascular bed.
Inmaculada Concepción Villar, Milagros Galisteo, Rocío Vera, Francisco O'Valle, María Francisca García-Saura

J Vasc Res· January 2005

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Effects of quercetin treatment on vascular function in deoxycorticosterone acetate-salt hypertensive rats. Comparative study with verapamil.
Milagros Galisteo, María Francisca García-Saura, Rosario Jiménez, Inmaculada Concepción Villar, Rosemary Wangensteen

Planta Med· April 2004

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Effects of chronic quercetin treatment on antioxidant defence system and oxidative status of deoxycorticosterone acetate-salt-hypertensive rats.
Milagros Galisteo, Maria Francisca García-Saura, Rosario Jiménez, Inmaculada Concepción Villar, Antonio Zarzuelo

Mol Cell Biochem· April 2004

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Effects of chronic chrysin treatment in spontaneously hypertensive rats.
Inmaculada Concepción Villar, Rosario Jiménez, Milagros Galisteo, Maria Francisca Garcia-Saura, Antonio Zarzuelo

Planta Med· September 2002

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