Publications by authors named "Iredia D Iyamu"

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Comparative Analysis of Two NNMT Bisubstrate Inhibitors through Chemoproteomic Studies: Uncovering the Role of Unconventional SAM Analogue Moiety for Improved Selectivity.
Ying Meng, Iredia D Iyamu, Noha A M Ahmed, Rong Huang

ACS Chem Biol· January 2024

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A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors.
Youchao Deng, Xiaosheng Song, Iredia D Iyamu, Aiping Dong, Jinrong Min

Acta Pharm Sin B· December 2023

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Structure-Activity Relationship Studies on Cell-Potent Nicotinamide -Methyltransferase Bisubstrate Inhibitors.
Iredia D Iyamu, Tianqi Zhao, Rong Huang

J Med Chem· August 2023

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Nicotinamide N-methyltransferase upregulation contributes to palmitate-elicited peroxisome proliferator-activated receptor transactivation in hepatocytes.
Qing Song, Jun Wang, Alexandra Griffiths, Samuel Man Lee, Iredia D Iyamu

Am J Physiol Cell Physiol· July 2023

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Going beyond Binary: Rapid Identification of Protein-Protein Interaction Modulators Using a Multifragment Kinetic Target-Guided Synthesis Approach.
Katya Nacheva, Sameer S Kulkarni, Mintesinot Kassu, David Flanigan, Andrii Monastyrskyi, Iredia D Iyamu

J Med Chem· April 2023

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Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a Specific DNA Adenine Methyltransferase.
Jujun Zhou, Youchao Deng, Iredia D Iyamu, John R Horton, Dan Yu

ACS Chem Biol· April 2023

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Effects of Small Molecule Ligands on ACKR3 Receptors.
Brittany E Hopkins, Ikuo Masuho, Dongjun Ren, Iredia D Iyamu, Wei Lv

Mol Pharmacol· September 2022

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Discovery of a small-molecule inhibitor of the TRIP8b-HCN interaction with efficacy in neurons.
Ye Han, Iredia D Iyamu, Matthew R Clutter, Rama K Mishra, Kyle A Lyman

J Biol Chem· July 2022

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Exploring Unconventional SAM Analogues To Build Cell-Potent Bisubstrate Inhibitors for Nicotinamide N-Methyltransferase.
Iredia D Iyamu, Jonah Z Vilseck, Ravi Yadav, Nicholas Noinaj, Rong Huang

Angew Chem Int Ed Engl· April 2022

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Structure-activity and structure-property relationship studies of spirocyclic chromanes with antimalarial activity.
Iredia D Iyamu, Yingzhao Zhao, Prakash T Parvatkar, Bracken F Roberts, Debora R Casandra

Bioorg Med Chem· March 2022

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Improved Cell-Potent and Selective Peptidomimetic Inhibitors of Protein N-Terminal Methyltransferase 1.
Guangping Dong, Iredia D Iyamu, Jonah Z Vilseck, Dongxing Chen, Rong Huang

Molecules· February 2022

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Nicotinamide N-methyltransferase upregulation via the mTORC1-ATF4 pathway activation contributes to palmitate-induced lipotoxicity in hepatocytes.
Alexandra Griffiths, Jun Wang, Qing Song, Iredia D Iyamu, Lifeng Liu

Am J Physiol Cell Physiol· September 2021

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Mechanisms and inhibitors of nicotinamide -methyltransferase.
Iredia D Iyamu, Rong Huang

RSC Med Chem· August 2021

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A Pan-Inhibitor for Protein Arginine Methyltransferase Family Enzymes.
Iredia D Iyamu, Ayad A Al-Hamashi, Rong Huang

Biomolecules· June 2021

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Development of fluorescence polarization-based competition assay for nicotinamide N-methyltransferase.
Iredia D Iyamu, Rong Huang

Anal Biochem· September 2020

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Novel Propargyl-Linked Bisubstrate Analogues as Tight-Binding Inhibitors for Nicotinamide -Methyltransferase.
Dongxing Chen, Linjie Li, Krystal Diaz, Iredia D Iyamu, Ravi Yadav

J Med Chem· December 2019

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Development of Tetrahydroindazole-Based Potent and Selective Sigma-2 Receptor Ligands.
Iredia D Iyamu, Wei Lv, Neha Malik, Rama K Mishra, Gary E Schiltz

ChemMedChem· July 2019

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Discovery of a novel class of potent and selective tetrahydroindazole-based sigma-1 receptor ligands.
Iredia D Iyamu, Wei Lv, Neha Malik, Rama K Mishra, Gary E Schiltz

Bioorg Med Chem· May 2019

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Synthesis of a novel fused pyrrolodiazepine-based library with anti-cancer activity.
Neha Malik, Iredia D Iyamu, Karl A Scheidt, Gary E Schiltz

Tetrahedron Lett· April 2018

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Menoctone Resistance in Malaria Parasites Is Conferred by M133I Mutations in Cytochrome That Are Transmissible through Mosquitoes.
Lynn D Blake, Myles E Johnson, Sasha V Siegel, Adonis McQueen, Iredia D Iyamu

Antimicrob Agents Chemother· August 2017

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Spirocyclic chromanes exhibit antiplasmodial activities and inhibit all intraerythrocytic life cycle stages.
Bracken F Roberts, Iredia D Iyamu, Sukjun Lee, Eunyoung Lee, Lawrence Ayong

Int J Parasitol Drugs Drug Resist· April 2016

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