Publications by authors named "Irene Barrett"

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Lead Optimization of Benzoxepin-Type Selective Estrogen Receptor (ER) Modulators and Downregulators with Subtype-Specific ERα and ERβ Activity.
Niamh M O'Boyle, Irene Barrett, Lisa M Greene, Miriam Carr, Darren Fayne

J Med Chem· January 2018

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An evolutionarily conserved synthetic lethal interaction network identifies FEN1 as a broad-spectrum target for anticancer therapeutic development.
Derek M van Pel, Irene J Barrett, Yoko Shimizu, Babu V Sajesh, Brent J Guppy

PLoS Genet· May 2013

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Synthetic lethality of cohesins with PARPs and replication fork mediators.
Jessica L McLellan, Nigel J O'Neil, Irene Barrett, Elizabeth Ferree, Derek M van Pel

PLoS Genet· September 2012

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R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants.
Peter C Stirling, Yujia A Chan, Sean W Minaker, Maria J Aristizabal, Irene Barrett

Genes Dev· January 2012

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Lead identification of conformationally restricted benzoxepin type combretastatin analogs: synthesis, antiproliferative activity, and tubulin effects.
Irene Barrett, Miriam Carr, Niamh O'Boyle, Lisa M Greene, Andrew J S Knox

J Enzyme Inhib Med Chem· April 2010

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Placental weight in pregnancies with trisomy confined to the placenta.
Paul J Yong, Peter von Dadelszen, Deborah E McFadden, Irene J Barrett, Dagmar K Kalousek

J Obstet Gynaecol Can· July 2009

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Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing.
Kirk J McManus, Irene J Barrett, Yasaman Nouhi, Philip Hieter

Proc Natl Acad Sci U S A· March 2009

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Synthesis, biological evaluation, structural-activity relationship, and docking study for a series of benzoxepin-derived estrogen receptor modulators.
Irene Barrett, Mary J Meegan, Rosario B Hughes, Miriam Carr, Andrew J S Knox

Bioorg Med Chem· November 2008

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Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers.
Thomas D Barber, Kirk McManus, Karen W Y Yuen, Marcelo Reis, Giovanni Parmigiani, Irene Barrett

Proc Natl Acad Sci U S A· March 2008

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Benzothiepin-derived molecular scaffolds for estrogen receptor modulators: synthesis and antagonistic effects in breast cancer cells.
Mary J Meegan, Irene Barrett, Jochen Zimmermann, Andrew J S Knox, Daniela M Zisterer

J Enzyme Inhib Med Chem· October 2007

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Postnatal follow-up of prenatally diagnosed trisomy 16 mosaicism.
Sylvie Langlois, Paul J Yong, Siu Li Yong, Irene Barrett, Dagmar K Kalousek

Prenat Diagn· June 2006

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Genome-wide synthetic lethal screens identify an interaction between the nuclear envelope protein, Apq12p, and the kinetochore in Saccharomyces cerevisiae.
Ben Montpetit, Ken Thorne, Irene Barrett, Kim Andrews, Ravi Jadusingh

Genetics· October 2005

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Origin of amnion and implications for evaluation of the fetal genotype in cases of mosaicism.
Wendy P Robinson, Deborah E McFadden, Irene J Barrett, Brian Kuchinka, Maria S Peñaherrera

Prenat Diagn· December 2002

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