Publications by authors named "Irwin Bernstein"

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Corrigendum: A germline point mutation in the MYC-FBW7 phosphodegron initiates hematopoietic malignancies.
Brian Freie, Patrick A Carroll, Barbara J Varnum-Finney, Erin L Ramsey, Vijay Ramani, Irwin Bernstein

Genes Dev· December 2025

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Differentiation latency and dormancy signatures define fetal liver hematopoietic stem cells at single-cell resolution.
Takashi Ishida, Juliane Mercoli, Adam M Heck, Ian Phelps, Barbara Varnum-Finney, Irwin D Bernstein

Cell Rep· October 2025

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Induction of Multipotential Hematopoietic Progenitors from Human Pluripotent Stem Cells via Respecification of Lineage-Restricted Precursors.
Sergei Doulatov, Linda T Vo, Stephanie S Chou, Peter G Kim, Natasha Arora, Irwin D Bernstein

Cell Stem Cell· June 2025

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Differentiation latency, cell division symmetry, and dormancy signatures define fetal liver HSCs at single cell resolution.
Takashi Ishida, Juliane Mercoli, Adam M Heck, Ian Phelps, Barbara Varnum-Finney, Irwin D Bernstein

bioRxiv· May 2025

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CBFA2T3-GLIS2 model of pediatric acute megakaryoblastic leukemia identifies FOLR1 as a CAR T cell target.
Quy Le, Brandon Hadland, Jenny L Smith, Amanda Leonti, Benjamin J Huang, Irwin D Bernstein

J Clin Invest· August 2024

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A germline point mutation in the MYC-FBW7 phosphodegron initiates hematopoietic malignancies.
Brian Freie, Patrick A Carroll, Barbara J Varnum-Finney, Erin L Ramsey, Vijay Ramani, Irwin Bernstein

Genes Dev· April 2024

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A Germline Point Mutation in the MYC-FBW7 Phosphodegron Initiates Hematopoietic Malignancies.
Brian Freie, Patrick A Carroll, Barbara J Varnum-Finney, Vijay Ramani, Irwin Bernstein

bioRxiv· October 2023

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Chromatin Profiling of CBFA2T3-GLIS2 AMLs Identifies Key Transcription Factor Dependencies and BRG1 Inhibition as a Novel Therapeutic Strategy.
Samantha Kaonis, Jenny L Smith, Neerja Katiyar, Morgan Merrill, Tiffany Hyelkma, Irwin Bernstein

bioRxiv· September 2023

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NOTCH1 signaling during CD4+ T-cell activation alters transcription factor networks and enhances antigen responsiveness.
Alec B Wilkens, Elena C Fulton, Margot J Pont, Gabriel O Cole, Isabel Leung, Irwin D Bernstein

Blood· November 2022

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CBFA2T3-GLIS2 model of pediatric acute megakaryoblastic leukemia identifies FOLR1 as a CAR T cell target.
Quy Le, Brandon Hadland, Jenny L Smith, Amanda Leonti, Benjamin J Huang, Irwin D Bernstein

J Clin Invest· November 2022

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Engineering a niche supporting hematopoietic stem cell development using integrated single-cell transcriptomics.
Brandon Hadland, Barbara Varnum-Finney, Stacey Dozono, Tessa Dignum, Cynthia Nourigat-McKay, Irwin D Bernstein

Nat Commun· March 2022

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Multipotent progenitors and hematopoietic stem cells arise independently from hemogenic endothelium in the mouse embryo.
Tessa Dignum, Barbara Varnum-Finney, Sanjay R Srivatsan, Stacey Dozono, Olivia Waltner, Irwin D Bernstein

Cell Rep· September 2021

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Inaccessible LCG Promoters Act as Safeguards to Restrict T Cell Development to Appropriate Notch Signaling Environments.
Suzanne Furuyama, Qian Vicky Wu, Barbara Varnum-Finney, Richard Sandstrom, Wouter Meuleman, Irwin D Bernstein

Stem Cell Reports· April 2021

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Notch blockade overcomes endothelial cell-mediated resistance of FLT3/ITD-positive AML progenitors to AC220 treatment.
Quy Le, Brandon Hadland, Soheil Meshinchi, Irwin Bernstein

Leukemia· February 2021

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Functional Properties of Mutations Are Associated with Differential Clinical Outcomes and Response to Targeted Therapeutics in CBF Acute Myeloid Leukemia.
Katherine Tarlock, Todd A Alonzo, Yi-Cheng Wang, Robert B Gerbing, Rhonda Ries, Irwin Bernstein

Clin Cancer Res· August 2019

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ABCB1 SNP predicts outcome in patients with acute myeloid leukemia treated with Gemtuzumab ozogamicin: a report from Children's Oncology Group AAML0531 Trial.
Roya Rafiee, Lata Chauhan, Todd A Alonzo, Yi-Cheng Wang, Ahlam Elmasry, Irwin D Bernstein

Blood Cancer J· May 2019

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CD33_PGx6_Score Predicts Gemtuzumab Ozogamicin Response in Childhood Acute Myeloid Leukemia: A Report From the Children's Oncology Group.
Lata Chauhan, Miyoung Shin, Yi-Cheng Wang, Michael Loken, Jessica Pollard, Irwin D Bernstein

JCO Precis Oncol· May 2019

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TALEN-Mediated Gene Editing of in Human Hematopoietic Stem Cells Leads to Therapeutic Fetal Hemoglobin Induction.
Christopher T Lux, Sowmya Pattabhi, Mason Berger, Cynthia Nourigat, David A Flowers, Irwin Bernstein

Mol Ther Methods Clin Dev· March 2019

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NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells.
Gene I Uenishi, Ho Sun Jung, Akhilesh Kumar, Mi Ae Park, Brandon K Hadland, Irwin D Bernstein

Nat Commun· May 2018

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Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture.
Brandon K Hadland, Barbara Varnum-Finney, Cynthia Nourigat-Mckay, David Flowers, Irwin D Bernstein

J Vis Exp· May 2018

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M1 and M2 macrophages differentially regulate hematopoietic stem cell self-renewal and ex vivo expansion.
Yi Luo, Lijian Shao, Jianhui Chang, Wei Feng, Y Lucy Liu, Irwin D Bernstein

Blood Adv· April 2018

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Maturation of hematopoietic stem cells from prehematopoietic stem cells is accompanied by up-regulation of PD-L1.
Joanna Tober, Marijke M W Maijenburg, Yan Li, Long Gao, Brandon K Hadland, Irwin D Bernstein

J Exp Med· February 2018

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Gemtuzumab ozogamicin for acute myeloid leukemia.
Frederick R Appelbaum, Irwin D Bernstein

Blood· November 2017

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CD33 Splicing Polymorphism Determines Gemtuzumab Ozogamicin Response in De Novo Acute Myeloid Leukemia: Report From Randomized Phase III Children's Oncology Group Trial AAML0531.
Jatinder K Lamba, Lata Chauhan, Miyoung Shin, Michael R Loken, Jessica A Pollard, Irwin D Bernstein

J Clin Oncol· August 2017

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Chromatin and Transcriptional Analysis of Mesoderm Progenitor Cells Identifies HOPX as a Regulator of Primitive Hematopoiesis.
Nathan J Palpant, Yuliang Wang, Brandon Hadland, Rebecca J Zaunbrecher, Meredith Redd, Irwin Bernstein

Cell Rep· August 2017

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