Publications by authors named "Isaac Klein"

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RNA and condensates: Disease implications and therapeutic opportunities.
Tina W Han, Bede Portz, Richard A Young, Ann Boija, Isaac A Klein

Cell Chem Biol· September 2024

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Biomolecular Condensates as Novel Antiviral Targets.
Erik W Martin, Christiane Iserman, Balaji Olety, Diana M Mitrea, Isaac A Klein

J Mol Biol· February 2024

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CD-CODE: crowdsourcing condensate database and encyclopedia.
Nadia Rostam, Soumyadeep Ghosh, Chi Fung Willis Chow, Anna Hadarovich, Cedric Landerer, Isaac A Klein

Nat Methods· May 2023

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Modulating biomolecular condensates: a novel approach to drug discovery.
Diana M Mitrea, Matthäus Mittasch, Beatriz Ferreira Gomes, Isaac A Klein, Mark A Murcko

Nat Rev Drug Discov· November 2022

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Principles and functions of condensate modifying drugs.
Avinash Patel, Diana Mitrea, Vigneshwaran Namasivayam, Mark A Murcko, Michael Wagner, Isaac A Klein

Front Mol Biosci· November 2022

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The transcription factor PAX8 promotes angiogenesis in ovarian cancer through interaction with SOX17.
Daniele Chaves-Moreira, Marilyn A Mitchell, Cristina Arruza, Priyanka Rawat, Simone Sidoli, Isaac A Klein

Sci Signal· April 2022

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Predicting master transcription factors from pan-cancer expression data.
Jessica Reddy, Marcos A S Fonseca, Rosario I Corona, Robbin Nameki, Felipe Segato Dezem, Isaac A Klein

Sci Adv· November 2021

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Impact of Cancer History on Outcomes Among Hospitalized Patients with COVID-19.
Isaac A Klein, Shoshana M Rosenberg, Kerry L Reynolds, Leyre Zubiri, Rachel Rosovsky

Oncologist· August 2021

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Engineering Bioactive Dimeric Transcription Factor Analogs via Palladium Rebound Reagents.
Muhammad Jbara, Sebastian Pomplun, Carly K Schissel, Susana Wilson Hawken, Ann Boija, Isaac Klein

J Am Chem Soc· August 2021

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Parallel Automated Flow Synthesis of Covalent Protein Complexes That Can Inhibit MYC-Driven Transcription.
Sebastian Pomplun, Muhammad Jbara, Carly K Schissel, Susana Wilson Hawken, Ann Boija, Isaac Klein

ACS Cent Sci· August 2021

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Impact of COVID-19 on Patients with Cancer Receiving Immune Checkpoint Inhibitors.
Ai-Tram N Bui, Kevin Tyan, Anita Giobbie-Hurder, Isaac A Klein, Michael P Manos

J Immunother Precis Oncol· May 2021

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Biomolecular Condensates and Cancer.
Ann Boija, Isaac A Klein, Richard A Young

Cancer Cell· February 2021

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lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation.
Kaveh Daneshvar, M Behfar Ardehali, Isaac A Klein, Fu-Kai Hsieh, Arcadia J Kratkiewicz

Nat Cell Biol· October 2020

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Partitioning of cancer therapeutics in nuclear condensates.
Isaac A Klein, Ann Boija, Lena K Afeyan, Susana Wilson Hawken, Mengyang Fan

Science· June 2020

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Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes.
Alicia V Zamudio, Alessandra Dall'Agnese, Jonathan E Henninger, John C Manteiga, Lena K Afeyan, Isaac A Klein

Mol Cell· December 2019

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Enhancer Features that Drive Formation of Transcriptional Condensates.
Krishna Shrinivas, Benjamin R Sabari, Eliot L Coffey, Isaac A Klein, Ann Boija

Mol Cell· August 2019

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Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains.
Ann Boija, Isaac A Klein, Benjamin R Sabari, Alessandra Dall'Agnese, Eliot L Coffey

Cell· December 2018

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Patient as Co-Teacher on Rounds: a Pilot Study.
Alyssa A Perez, Stephen R Pelletier, Isaac A Klein, Helen M Shields

J Gen Intern Med· July 2018

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Coactivator condensation at super-enhancers links phase separation and gene control.
Benjamin R Sabari, Alessandra Dall'Agnese, Ann Boija, Isaac A Klein, Eliot L Coffey

Science· July 2018

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High-throughput sequencing reveals principles of adeno-associated virus serotype 2 integration.
Tyler Janovitz, Isaac A Klein, Thiago Oliveira, Piali Mukherjee, Michel C Nussenzweig

J Virol· August 2013

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53BP1 alters the landscape of DNA rearrangements and suppresses AID-induced B cell lymphoma.
Mila Jankovic, Niklas Feldhahn, Thiago Y Oliveira, Israel T Silva, Kyong-Rim Kieffer-Kwon, Isaac Klein

Mol Cell· February 2013

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Activation-induced cytidine deaminase in antibody diversification and chromosome translocation.
Anna Gazumyan, Anne Bothmer, Isaac A Klein, Michel C Nussenzweig, Kevin M McBride

Adv Cancer Res· July 2012

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Mouse model of endemic Burkitt translocations reveals the long-range boundaries of Ig-mediated oncogene deregulation.
Alexander L Kovalchuk, Camilo Ansarah-Sobrinho, Ofir Hakim, Wolfgang Resch, Helena Tolarová, Isaac Klein

Proc Natl Acad Sci U S A· July 2012

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DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes.
Ofir Hakim, Wolfgang Resch, Arito Yamane, Isaac Klein, Kyong-Rim Kieffer-Kwon

Nature· February 2012

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Translocation capture sequencing: a method for high throughput mapping of chromosomal rearrangements.
Thiago Y Oliveira, Wolfgang Resch, Mila Jankovic, Rafael Casellas, Michel C Nussenzweig, Isaac A Klein

J Immunol Methods· January 2012

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