Publications by authors named "Isabel Pappworth"

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The membrane attack complex drives thrombotic microangiopathy in complement mediated atypical hemolytic uremic syndrome.
Kate Smith-Jackson, Patrick Walsh, Wioleta M Zelek, Thomas Hoyler, Marianne M Martinic, Isabel Y Pappworth

Kidney Int· April 2025

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Determining the Potential of DNA Damage Response (DDR) Inhibitors in Cervical Cancer Therapy.
Santu Saha, Stuart Rundle, Ioannis C Kotsopoulos, Jacob Begbie, Rachel Howarth, Isabel Y Pappworth

Cancers (Basel)· September 2022

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Homodimeric Minimal Factor H: Tracking and Extended Dosing Studies in Factor H Deficient Mice.
Ola Kamala, Talat H Malik, Thomas M Hallam, Thomas E Cox, Yi Yang, Isabel Y Pappworth

Front Immunol· February 2022

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C3 Glomerulopathy and Related Disorders in Children: Etiology-Phenotype Correlation and Outcomes.
Edwin K S Wong, Kevin J Marchbank, Hannah Lomax-Browne, Isabel Y Pappworth, Harriet Denton

Clin J Am Soc Nephrol· November 2021

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Murine Factor H Co-Produced in Yeast With Protein Disulfide Isomerase Ameliorated C3 Dysregulation in Factor H-Deficient Mice.
Heather Kerr, Andrew P Herbert, Elisavet Makou, Dariusz Abramczyk, Talat H Malik, Isabel Y Pappworth

Front Immunol· October 2021

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Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice.
Kate Smith-Jackson, Yi Yang, Harriet Denton, Isabel Y Pappworth, Katie Cooke

J Clin Invest· March 2019

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A novel C3d-containing oligomeric vaccine provides insight into the viability of testing human C3d-based vaccines in mice.
Yong-Gang He, Isabel Y Pappworth, Andreas Rossbach, Joshua Paulin, Tarirai Mavimba

Immunobiology· January 2018

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Selectivity of C3-opsonin targeted complement inhibitors: A distinct advantage in the protection of erythrocytes from paroxysmal nocturnal hemoglobinuria patients.
Christoph Q Schmidt, Markus J Harder, Eva-Maria Nichols, Mario Hebecker, Markus Anliker, Isabel Y Pappworth

Immunobiology· April 2016

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An extended mini-complement factor H molecule ameliorates experimental C3 glomerulopathy.
Eva-Maria Nichols, Thomas D Barbour, Isabel Y Pappworth, Edwin K S Wong, Jeremy M Palmer

Kidney Int· December 2015

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Autoantibodies to CD59, CD55, CD46 or CD35 are not associated with atypical haemolytic uraemic syndrome (aHUS).
Rachael Watson, Emma Wearmouth, Amy-Claire McLoughlin, Arthur Jackson, Sophie Ward, Isabel Y Pappworth

Mol Immunol· February 2015

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Factor H autoantibodies in membranoproliferative glomerulonephritis.
Timothy H J Goodship, Isabel Y Pappworth, Tibor Toth, Mark Denton, Kris Houlberg

Mol Immunol· October 2012

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Factor I autoantibodies in patients with atypical hemolytic uremic syndrome: disease-associated or an epiphenomenon?
David Kavanagh, Isabel Y Pappworth, Holly Anderson, Christine M Hayes, Iain Moore

Clin J Am Soc Nephrol· March 2012

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Mice expressing human CR1/CD35 have an enhanced humoral immune response to T-dependent antigens but fail to correct the effect of premature human CR2 expression.
Isabel Y Pappworth, Christine Hayes, Jason Dimmick, B Paul Morgan, V Michael Holers

Immunobiology· February 2012

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Complement factor h autoantibodies and age-related macular degeneration.
Baljean Dhillon, Alan F Wright, Adnan Tufail, Isabel Pappworth, Caroline Hayward

Invest Ophthalmol Vis Sci· November 2010

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Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome.
Iain Moore, Lisa Strain, Isabel Pappworth, David Kavanagh, Paul N Barlow

Blood· January 2010

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Defective B cell ontogeny and humoral immune response in mice prematurely expressing human complement receptor 2 (CR2, CD21) is similar to that seen in aging wild type mice.
Jason P Twohig, Isabel Y Pappworth, Baalasubramanian Sivasankar, Liudmila Kulik, Melanie Bull

Mol Immunol· June 2009

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Increased B cell deletion and significantly reduced auto-antibody titre due to premature expression of human complement receptor 2 (CR2, CD21).
Isabel Y Pappworth, Liudmila Kulik, Catherine Haluszczak, Jason W Reuter, V Michael Holers

Mol Immunol· March 2009

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The switch from latent to productive infection in epstein-barr virus-infected B cells is associated with sensitization to NK cell killing.
Isabel Y Pappworth, Eddie C Wang, Martin Rowe

J Virol· January 2007

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Impaired transporter associated with antigen processing-dependent peptide transport during productive EBV infection.
Maaike E Ressing, Sinéad E Keating, Daphne van Leeuwen, Danijela Koppers-Lalic, Isabel Y Pappworth

J Immunol· June 2005

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