Publications by authors named "Isabelle Brun-Heath"

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Systematic study of hybrid triplex topology and stability suggests a general triplex-mediated regulatory mechanism.
Vito Genna, Guillem Portella, Alba Sala, Montserrat Terrazas, Israel Serrano-Chacón, Isabelle Brun-Heath

Nucleic Acids Res· February 2025

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An integrated machine-learning model to predict nucleosome architecture.
Alba Sala, Mireia Labrador, Diana Buitrago, Pau De Jorge, Federica Battistini

Nucleic Acids Res· September 2024

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Rational optimization of a transcription factor activation domain inhibitor.
Shaon Basu, Paula Martínez-Cristóbal, Marta Frigolé-Vivas, Mireia Pesarrodona, Michael Lewis, Isabelle Brun-Heath

Nat Struct Mol Biol· December 2023

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Histone H3 serine-57 is a CHK1 substrate whose phosphorylation affects DNA repair.
Nikolaos Parisis, Pablo D Dans, Muhammad Jbara, Balveer Singh, Diane Schausi-Tiffoche, Isabelle Brun-Heath

Nat Commun· August 2023

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Controlled sulfur-based engineering confers mouldability to phosphorothioate antisense oligonucleotides.
Vito Genna, Javier Iglesias-Fernández, Laura Reyes-Fraile, Nuria Villegas, Kevin Guckian, Isabelle Brun-Heath

Nucleic Acids Res· June 2023

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Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway.
Lorena González, Lucía Díaz, Joan Pous, Blazej Baginski, Anna Duran-Corbera, Isabelle Brun-Heath

Nat Commun· June 2023

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A method for multiplexed full-length single-molecule sequencing of the human mitochondrial genome.
Ieva Keraite, Philipp Becker, Davide Canevazzi, Cristina Frias-López, Marc Dabad, Isabelle Brun-Heath

Nat Commun· October 2022

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MiOS, an integrated imaging and computational strategy to model gene folding with nucleosome resolution.
Maria Victoria Neguembor, Juan Pablo Arcon, Diana Buitrago, Rafael Lema, Jürgen Walther

Nat Struct Mol Biol· October 2022

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Mechanism of reaction of RNA-dependent RNA polymerase from SARS-CoV-2.
Juan Aranda, Milosz Wieczór, Montserrat Terrazas, Isabelle Brun-Heath, Modesto Orozco

Chem Catal· May 2022

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Molecular basis of Arginine and Lysine DNA sequence-dependent thermo-stability modulation.
Benjamin Martin, Pablo D Dans, Milosz Wieczór, Nuria Villegas, Isabelle Brun-Heath

PLoS Comput Biol· January 2022

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The Impact of the HydroxyMethylCytosine epigenetic signature on DNA structure and function.
Federica Battistini, Pablo D Dans, Montserrat Terrazas, Chiara L Castellazzi, Guillem Portella, Isabelle Brun-Heath

PLoS Comput Biol· November 2021

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Bioactivity descriptors for uncharacterized chemical compounds.
Martino Bertoni, Miquel Duran-Frigola, Pau Badia-I-Mompel, Eduardo Pauls, Modesto Orozco-Ruiz, Isabelle Brun-Heath

Nat Commun· June 2021

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Impact of DNA methylation on 3D genome structure.
Diana Buitrago, Mireia Labrador, Juan Pablo Arcon, Rafael Lema, Oscar Flores

Nat Commun· May 2021

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Bioactivity Profile Similarities to Expand the Repertoire of COVID-19 Drugs.
Miquel Duran-Frigola, Martino Bertoni, Roi Blanco, Víctor Martínez, Eduardo Pauls, Isabelle Brun-Heath

J Chem Inf Model· December 2020

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Nucleosome Dynamics: a new tool for the dynamic analysis of nucleosome positioning.
Diana Buitrago, Laia Codó, Ricard Illa, Pau de Jorge, Federica Battistini

Nucleic Acids Res· October 2019

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Author Correction: Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor.
Bahareh Eftekharzadeh, Varuna C Banduseela, Giulio Chiesa, Paula Martínez-Cristóbal, Jennifer N Rauch, Isabelle Brun-Heath

Nat Commun· October 2019

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Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor.
Bahareh Eftekharzadeh, Varuna C Banduseela, Giulio Chiesa, Paula Martínez-Cristóbal, Jennifer N Rauch, Isabelle Brun-Heath

Nat Commun· August 2019

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Oncogenic mutations at the EGFR ectodomain structurally converge to remove a steric hindrance on a kinase-coupled cryptic epitope.
Laura Orellana, Amy H Thorne, Rafael Lema, Johan Gustavsson, Alison D Parisian, Isabelle Brun-Heath

Proc Natl Acad Sci U S A· May 2019

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A multifunctional toolkit for target-directed cancer therapy.
Montserrat Terrazas, Dani Sánchez, Federica Battistini, Núria Villegas, Isabelle Brun-Heath

Chem Commun (Camb)· January 2019

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Regulation of Androgen Receptor Activity by Transient Interactions of Its Transactivation Domain with General Transcription Regulators.
Eva De Mol, Elzbieta Szulc, Claudio Di Sanza, Paula Martínez-Cristóbal, Carlos W Bertoncini, Isabelle Brun-Heath

Structure· January 2018

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Efficient siRNA-peptide conjugation for specific targeted delivery into tumor cells.
Albert Gandioso, Anna Massaguer, Núria Villegas, Cándida Salvans, Dani Sánchez, Isabelle Brun-Heath

Chem Commun (Camb)· March 2017

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Rational design of novel N-alkyl-N capped biostable RNA nanostructures for efficient long-term inhibition of gene expression.
Montserrat Terrazas, Ivan Ivani, Núria Villegas, Clément Paris, Cándida Salvans, Isabelle Brun-Heath

Nucleic Acids Res· May 2016

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Whole-genome bisulfite sequencing of two distinct interconvertible DNA methylomes of mouse embryonic stem cells.
Ehsan Habibi, Arie B Brinkman, Julia Arand, Leonie I Kroeze, Hindrik H D Kerstens, Isabelle Brun-Heath

Cell Stem Cell· September 2013

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Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia.
Marta Kulis, Simon Heath, Marina Bibikova, Ana C Queirós, Alba Navarro, Isabelle Brun-Heath

Nat Genet· November 2012

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Differential expression of the bone and the liver tissue non-specific alkaline phosphatase isoforms in brain tissues.
Isabelle Brun-Heath, Myriam Ermonval, Elodie Chabrol, Jinsong Xiao, Miklós Palkovits

Cell Tissue Res· March 2011

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