Publications by authors named "Isabelle Lyothier"

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Discovery of Novel Aminopyrimidines as Selective EP2 Receptor Antagonists.
Isabelle Lyothier, Stefan Diethelm, Julien Pothier, Thierry Sifferlen, Davide Pozzi

ChemMedChem· June 2025

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Discovery of ACT-1002-4271 as a Dual Prostaglandin E2 Receptor 2/Prostaglandin E2 Receptor 4 Antagonist with In Vivo Anti-Tumor Efficacy.
Isabelle Lyothier, Stefan Diethelm, Julien Pothier, Thierry Sifferlen, Davide Pozzi

ChemMedChem· June 2025

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Design of Dual EP2/EP4 Antagonists through Scaffold Merging of Selective Inhibitors.
Olivier Corminboeuf, Stefan Diethelm, Cornelia Zumbrunn, Isabelle Lyothier, Nadja Niggli

ChemMedChem· January 2024

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Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration.
Edward K Dziadulewicz, Stuart J Bevan, Christopher T Brain, Paul R Coote, Andrew J Culshaw, Isabelle Lyothier

J Med Chem· August 2007

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The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide.
Víctor M Sánchez-Pedregal, Karel Kubicek, Jens Meiler, Isabelle Lyothier, Ian Paterson

Angew Chem Int Ed Engl· November 2006

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Iridium-catalyzed enantioselective synthesis of allylic alcohols: silanolates as hydroxide equivalents.
Isabelle Lyothier, Christian Defieber, Erick M Carreira

Angew Chem Int Ed Engl· September 2006

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Identification and biological characterization of 6-aryl-7-isopropylquinazolinones as novel TRPV1 antagonists that are effective in models of chronic pain.
Andrew J Culshaw, Stuart Bevan, Martin Christiansen, Prafula Copp, Andrew Davis, Isabelle Lyothier

J Med Chem· January 2006

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Development of a third-generation total synthesis of (+)-discodermolide: an expedient Still-Gennari-type fragment coupling utilizing an advanced beta-ketophosphonate.
Ian Paterson, Isabelle Lyothier

J Org Chem· July 2005

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A second-generation total synthesis of (+)-discodermolide: the development of a practical route using solely substrate-based stereocontrol.
Ian Paterson, Oscar Delgado, Gordon J Florence, Isabelle Lyothier, Matthew O'Brien

J Org Chem· January 2005

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Total synthesis of (+)-discodermolide: an improved endgame exploiting a Still-Gennari-type olefination with a C1-C8 beta-ketophosphonate fragment.
Ian Paterson, Isabelle Lyothier

Org Lett· December 2004

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1,6-asymmetric induction in boron-mediated aldol reactions: application to a practical total synthesis of (+)-discodermolide.
Ian Paterson, Oscar Delgado, Gordon J Florence, Isabelle Lyothier, Jeremy P Scott

Org Lett· January 2003

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