Publications by authors named "Julien Pothier"

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Cellular Potency Optimization of Novel Heme-Binding Imidazo[5,1-]thiazoles, Imidazo[1,5-]pyridines and Pyrazines as Potent IDO1 Inhibitors Devoid of Cytochrome P450 Inhibition.
Sylvaine Cren, Carina Lotz-Jenne, Thierry Kimmerlin, Julien Pothier, Philippe Risch

J Med Chem· October 2025

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Discovery of Novel Aminopyrimidines as Selective EP2 Receptor Antagonists.
Isabelle Lyothier, Stefan Diethelm, Julien Pothier, Thierry Sifferlen, Davide Pozzi

ChemMedChem· June 2025

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Discovery of ACT-1002-4271 as a Dual Prostaglandin E2 Receptor 2/Prostaglandin E2 Receptor 4 Antagonist with In Vivo Anti-Tumor Efficacy.
Isabelle Lyothier, Stefan Diethelm, Julien Pothier, Thierry Sifferlen, Davide Pozzi

ChemMedChem· June 2025

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Discovery of the Potent, Selective, Orally Available CXCR7 Antagonist ACT-1004-1239.
Sylvia Richard-Bildstein, Hamed Aissaoui, Julien Pothier, Gabriel Schäfer, Carmela Gnerre

J Med Chem· December 2020

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Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968).
Philippe Risch, Thomas Pfeifer, Jerome Segrestaa, Heinz Fretz, Julien Pothier

J Med Chem· October 2015

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Identification of 2-(2-(1-naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic acid (setipiprant/ACT-129968), a potent, selective, and orally bioavailable chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) antagonist.
Heinz Fretz, Anja Valdenaire, Julien Pothier, Kurt Hilpert, Carmela Gnerre

J Med Chem· June 2013

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Evolution of novel tricyclic CRTh2 receptor antagonists from a (E)-2-cyano-3-(1H-indol-3-yl)acrylamide scaffold.
Anja Valdenaire, Julien Pothier, Dorte Renneberg, Markus A Riederer, Oliver Peter

Bioorg Med Chem Lett· February 2013

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Novel 2-(2-(benzylthio)-1H-benzo[d]imidazol-1-yl)acetic acids: discovery and hit-to-lead evolution of a selective CRTh2 receptor antagonist chemotype.
Julien Pothier, Markus A Riederer, Oliver Peter, Xavier Leroy, Anja Valdenaire

Bioorg Med Chem Lett· July 2012

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