Publications by authors named "Isao Yoshimura"

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Optimal patch application time in the evaluation of skin irritation.
Hiromi Kanto, Kumiko Washizaki, Masatoshi Ito, Kayoko Matsunaga, Hirohiko Akamatsu, Isao Yoshimura

J Dermatol· May 2013

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Sample size calculation through the incorporation of heteroscedasticity and dependence for a penalized t-statistic in microarray experiments.
Akihiro Hirakawa, Chikuma Hamada, Isao Yoshimura

J Biopharm Stat· May 2012

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Validation study of the in vitro skin irritation test with the LabCyte EPI-MODEL24.
Hajime Kojima, Yoko Ando, Kenji Idehara, Masakazu Katoh, Tadashi Kosaka, Isao Yoshimura

Altern Lab Anim· March 2012

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Inter-laboratory validation of the modified murine local lymph node assay based on 5-bromo-2'-deoxyuridine incorporation.
Hajime Kojima, Masahiro Takeyoshi, Takashi Sozu, Takumi Awogi, Kazunori Arima, Isao Yoshimura

J Appl Toxicol· January 2011

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Statistical screening method for genetic factors influencing susceptibility to common diseases in a two-stage genome-wide association study.
Yasunori Sato, Nan Laird, Hideki Suganami, Chikuma Hamada, Naoto Niki, Isao Yoshimura

Stat Appl Genet Mol Biol· March 2010

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Application of the improved BALB/c 3T3 cell transformation assay to the examination of the initiating and promoting activities of chemicals: the second interlaboratory collaborative study by the non-genotoxic carcinogen study group of Japan.
Toshiyuki Tsuchiya, Makoto Umeda, Noriho Tanaka, Ayako Sakai, Hiroshi Nishiyama, Isao Yoshimura

Altern Lab Anim· March 2010

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A note on estimating treatment effect for time-to-event data in a literature-based meta-analysis.
Tadashi Hirooka, Chikuma Hamada, Isao Yoshimura

Methods Inf Med· August 2009

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Optimal two-stage designs allowing flexibility in number of subjects for phase II clinical trials.
Nobuyuki Masaki, Tatsuki Koyama, Isao Yoshimura, Chikuma Hamada

J Biopharm Stat· July 2009

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Technical modification of the Balb/c 3T3 cell transformation assay: the use of serum-reduced medium to optimise the practicability of the protocol.
Kumiko Hayashi, Kiyoshi Sasaki, Shin Asada, Toshiyuki Tsuchiya, Makoto Hayashi, Isao Yoshimura

Altern Lab Anim· December 2008

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Interlaboratory validation of the modified murine local lymph node assay based on adenosine triphosphate measurement.
Takashi Omori, Kenji Idehara, Hajime Kojima, Takashi Sozu, Kazunori Arima, Isao Yoshimura

J Pharmacol Toxicol Methods· October 2008

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[Improvement of precision in pharmacological studies using the non-linear regression method: estimation of enzyme inhibition constants as an example].
Akiko Yamazaki, Eisuke Kume, Sumiko Tanaka, Chikuma Hamada, Isao Yoshimura

Nihon Yakurigaku Zasshi· March 2008

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A new test statistic based on shrunken sample variance for identifying differentially expressed genes in small microarray experiments.
Akihiro Hirakawa, Yasunori Sato, Chikuma Hamada, Isao Yoshimura

Bioinform Biol Insights· February 2008

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Estimating the false discovery rate using mixed normal distribution for identifying differentially expressed genes in microarray data analysis.
Akihiro Hirakawa, Yasunori Sato, Takashi Sozu, Chikuma Hamada, Isao Yoshimura

Cancer Inform· January 2008

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Criteria revision and performance comparison of three methods of signal detection applied to the spontaneous reporting database of a pharmaceutical manufacturer.
Yasuyuki Matsushita, Yasufumi Kuroda, Shinpei Niwa, Satoshi Sonehara, Chikuma Hamada, Isao Yoshimura

Drug Saf· October 2007

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A method for therapeutic dose selection in a phase II clinical trial using contrast statistics.
Akira Wakana, Isao Yoshimura, Chikuma Hamada

Stat Med· February 2007

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Influence of SNPs in cytokine-related genes on the severity of food allergy and atopic eczema in children.
Takaharu Negoro, Kanami Orihara, Tomoko Irahara, Hiroshi Nishiyama, Kanae Hagiwara, Isao Yoshimura

Pediatr Allergy Immunol· December 2006

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The confidence interval of allelic odds ratios under the Hardy-Weinberg disequilibrium.
Yasunori Sato, Hideki Suganami, Chikuma Hamada, Isao Yoshimura, Hiromi Sakamoto, Kimio Yoshimura

J Hum Genet· November 2006

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Minimization method for balancing continuous prognostic variables between treatment and control groups using Kullback-Leibler divergence.
Akira Endo, Fumio Nagatani, Chikuma Hamada, Isao Yoshimura

Contemp Clin Trials· October 2006

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Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy: the 3-year, multicenter, comparative Aldose Reductase Inhibitor-Diabetes Complications Trial.
Nigishi Hotta, Yasuo Akanuma, Ryuzo Kawamori, Kempei Matsuoka, Yoshitomo Oka, Isao Yoshimura

Diabetes Care· July 2006

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Existence of a no effect level for MeIQx hepatocarcinogenicity on a background of thioacetamide-induced liver damage in rats.
Jin Seok Kang, Hideki Wanibuchi, Keiichirou Morimura, Yukari Totsuka, Isao Yoshimura

Cancer Sci· June 2006

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Effective number of subjects and number of raters for inter-rater reliability studies.
Yuki Saito, Takashi Sozu, Chikuma Hamada, Isao Yoshimura

Stat Med· May 2006

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Mouse lymphoma thymidine kinase gene mutation assay: follow-up meeting of the International Workshop on Genotoxicity Testing--Aberdeen, Scotland, 2003--Assay acceptance criteria, positive controls, and data evaluation.
Martha M Moore, Masamitsu Honma, Julie Clements, George Bolcsfoldi, Brian Burlinson, Isao Yoshimura

Environ Mol Mutagen· January 2006

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An inter-laboratory collaborative study by the Non-Genotoxic Carcinogen Study Group in Japan, on a cell transformation assay for tumour promoters using Bhas 42 cells.
Kiyomi Ohmori, Makoto Umeda, Noriho Tanaka, Hiroki Takagi, Isao Yoshimura

Altern Lab Anim· December 2005

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Fluorescent compounds from the cultured mycobiont of Amygdalaria panaeola.
Kaoru Kinoshita, Yoshikazu Yamamoto, Kazuhiko Takatori, Kiyotaka Koyama, Kunio Takahashi, Isao Yoshimura

J Nat Prod· December 2005

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Antioxidants and photoprotection in a lichen as compared with its isolated symbiotic partners.
Ilse Kranner, W John Cram, Margret Zorn, Sabine Wornik, Isao Yoshimura

Proc Natl Acad Sci U S A· February 2005

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