Publications by authors named "Iyassu Sebhat"

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Gut enteroendocrine cell activation using a combination of GPR119 and GPR40 agonists results in synergistic hormone secretion in mice and humans.
Iyassu K Sebhat, Monika J M Murphy, Shuqin Zheng, Robert J Lovelett, Maja Engelstoft

Cell Metab· December 2025

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AMPK Activation by MK-8722 Measured with [F]FDG-PET Imaging in Rodents and Non-Human Primates.
Daniel J Rubins, Xiangjun Meng, Shubing Wang, Hyking Haley, Diane Posavec, Iyassu K Sebhat

Mol Imaging Biol· December 2025

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Discovery of Gut-Targeted GPR40 Agonist K-757 and GPR119 Agonist K-833, a Combination Treatment for Metabolic Disorders.
Christopher R Moyes, Shuwen He, Simon Mathieu, Sara L Lehman, Macrina T Francisco, Iyassu K Sebhat

J Med Chem· August 2025

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Annotated Bibliography of Dr. Arthur A. Patchett.
Ravi Nargund, Matthew Wyvratt, Songnian Lin, Iyassu Sebhat, William Greenlee

J Med Chem· December 2023

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Molecular Profiling Reveals a Common Metabolic Signature of Tissue Fibrosis.
Ji Zhang, Eric S Muise, Seongah Han, Peter S Kutchukian, Philippe Costet, Iyassu K Sebhat

Cell Rep Med· July 2020

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Pharmacological AMPK activation induces transcriptional responses congruent to exercise in skeletal and cardiac muscle, adipose tissues and liver.
Eric S Muise, Hong-Ping Guan, Jinqi Liu, Andrea R Nawrocki, Xiaodong Yang, Iyassu K Sebhat

PLoS One· December 2019

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PAN-AMPK Activation Improves Renal Function in a Rat Model of Progressive Diabetic Nephropathy.
Xiaoyan Zhou, Eric S Muise, Robin Haimbach, Iyassu K Sebhat, Yonghua Zhu

J Pharmacol Exp Ther· October 2019

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Discovery of MK-8722: A Systemic, Direct Pan-Activator of AMP-Activated Protein Kinase.
Danqing Feng, Tesfaye Biftu, F Anthony Romero, Ahmet Kekec, James Dropinski, Iyassu K Sebhat

ACS Med Chem Lett· January 2018

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Hit-to-Lead Optimization and Discovery of 5-((5-([1,1'-Biphenyl]-4-yl)-6-chloro-1H-benzo[d]imidazol-2-yl)oxy)-2-methylbenzoic Acid (MK-3903): A Novel Class of Benzimidazole-Based Activators of AMP-Activated Protein Kinase.
Ping Lan, F Anthony Romero, Dariusz Wodka, Andrew J Kassick, Qun Dang, Iyassu K Sebhat

J Med Chem· November 2017

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Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy.
Robert W Myers, Hong-Ping Guan, Juliann Ehrhart, Aleksandr Petrov, Srinivasa Prahalada, Iyassu K Sebhat

Science· August 2017

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Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).
Sylvain Celanire, Iyassu Sebhat, Juergen Wichmann, Stanislas Mayer, Stephan Schann

Expert Opin Ther Pat· January 2015

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A new class of prolylcarboxypeptidase inhibitors, part 1: discovery and evaluation.
Thomas H Graham, Wensheng Liu, Andreas Verras, Iyassu K Sebhat, Yusheng Xiong

Bioorg Med Chem Lett· April 2012

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Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist.
Qingmei Hong, Raman K Bakshi, Brenda L Palucki, Min K Park, Zhixiong Ye, Iyassu K Sebhat

Bioorg Med Chem Lett· April 2011

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Antiobesity effect of MK-5046, a novel bombesin receptor subtype-3 agonist.
Xiao-Ming Guan, Joseph M Metzger, Liming Yang, Kate A Raustad, Sheng-Ping Wang, Iyassu Sebhat

J Pharmacol Exp Ther· February 2011

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Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity.
Iyassu K Sebhat, Christopher Franklin, Michael M-C Lo, David Chen, James P Jewell

ACS Med Chem Lett· January 2011

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Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesity.
Shuwen He, Zhixiong Ye, Peter H Dobbelaar, Raman K Bakshi, Qingmei Hong, Iyassu K Sebhat

Bioorg Med Chem Lett· November 2010

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Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands.
Qingmei Hong, Raman K Bakshi, James Dellureficio, Shuwen He, Zhixiong Ye, Iyassu K Sebhat

Bioorg Med Chem Lett· August 2010

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Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity.
Shuwen He, Zhixiong Ye, Peter H Dobbelaar, Iyassu K Sebhat, Liangqin Guo

Bioorg Med Chem Lett· August 2010

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Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists.
Liangqin Guo, Zhixiong Ye, Jian Liu, Shuwen He, Raman K Bakshi, Iyassu K Sebhat

Bioorg Med Chem Lett· August 2010

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Synthesis and SAR of heterocyclic carboxylic acid isosteres based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity.
Mark Hadden, Allan Goodman, Cheng Guo, Peter R Guzzo, Alan J Henderson, Iyassu K Sebhat

Bioorg Med Chem Lett· May 2010

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Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist.
Shuwen He, Zhixiong Ye, Peter H Dobbelaar, Iyassu K Sebhat, Liangqin Guo

Bioorg Med Chem Lett· April 2010

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Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity.
Jian Liu, Shuwen He, Tianying Jian, Peter H Dobbelaar, Iyassu K Sebhat

Bioorg Med Chem Lett· April 2010

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Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists.
Shuwen He, Peter H Dobbelaar, Jian Liu, Tianying Jian, Iyassu K Sebhat

Bioorg Med Chem Lett· March 2010

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Synthesis and SAR of potent and orally bioavailable tert-butylpyrrolidine archetype derived melanocortin subtype-4 receptor modulators.
Liangqin Guo, Zhixiong Ye, Feroze Ujjainwalla, Heather L Sings, Iyassu K Sebhat

Bioorg Med Chem Lett· June 2008

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Melanocortin subtype 4 receptor agonists: structure-activity relationships about the 4-alkyl piperidine core.
Iyassu K Sebhat, Yingjie Lai, Khaled Barakat, Zhixiong Ye, Rui Tang

Bioorg Med Chem Lett· October 2007

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