Publications by authors named "Matthew Wyvratt"

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A
Arthur A. Patchett Memorial Issue.
Matthew Wyvratt, William Greenlee

J Med Chem· December 2023

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Annotated Bibliography of Dr. Arthur A. Patchett.
Ravi Nargund, Matthew Wyvratt, Songnian Lin, Iyassu Sebhat, William Greenlee

J Med Chem· December 2023

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Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum.
Akhil B Vaidya, Joanne M Morrisey, Zhongsheng Zhang, Sudipta Das, Thomas M Daly, Matthew Wyvratt

Nat Commun· November 2014

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Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain.
Harry R Chobanian, Yan Guo, Ping Liu, Marc D Chioda, Selena Fung, Matthew J Wyvratt

ACS Med Chem Lett· June 2014

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1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia.
Petr Vachal, Shouwu Miao, Joan M Pierce, Deodial Guiadeen, Vincent J Colandrea, Matthew J Wyvratt

J Med Chem· April 2012

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Discovery of benzodiazepine sulfonamide-based bombesin receptor subtype 3 agonists and their unusual chirality.
Ping Liu, Thomas J Lanza, Marc Chioda, Carrie Jones, Harry R Chobanian, Matthew J Wyvratt

ACS Med Chem Lett· December 2011

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Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist.
Qingmei Hong, Raman K Bakshi, Brenda L Palucki, Min K Park, Zhixiong Ye, Matthew J Wyvratt

Bioorg Med Chem Lett· April 2011

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Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity.
Iyassu K Sebhat, Christopher Franklin, Michael M-C Lo, David Chen, James P Jewell, Matthew J Wyvratt

ACS Med Chem Lett· January 2011

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Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesity.
Shuwen He, Zhixiong Ye, Peter H Dobbelaar, Raman K Bakshi, Qingmei Hong, Matthew J Wyvratt

Bioorg Med Chem Lett· November 2010

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Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands.
Qingmei Hong, Raman K Bakshi, James Dellureficio, Shuwen He, Zhixiong Ye, Matthew J Wyvratt

Bioorg Med Chem Lett· August 2010

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Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity.
Shuwen He, Zhixiong Ye, Peter H Dobbelaar, Iyassu K Sebhat, Liangqin Guo, Matthew J Wyvratt

Bioorg Med Chem Lett· August 2010

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Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists.
Liangqin Guo, Zhixiong Ye, Jian Liu, Shuwen He, Raman K Bakshi, Matthew J Wyvratt

Bioorg Med Chem Lett· August 2010

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Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist.
Shuwen He, Zhixiong Ye, Peter H Dobbelaar, Iyassu K Sebhat, Liangqin Guo, Matthew J Wyvratt

Bioorg Med Chem Lett· April 2010

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Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity.
Jian Liu, Shuwen He, Tianying Jian, Peter H Dobbelaar, Iyassu K Sebhat, Matthew J Wyvratt

Bioorg Med Chem Lett· April 2010

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Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists.
Shuwen He, Peter H Dobbelaar, Jian Liu, Tianying Jian, Iyassu K Sebhat, Matthew J Wyvratt

Bioorg Med Chem Lett· March 2010

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Discovery of the development candidate N-tert-butyl nodulisporamide: a safe and efficacious once monthly oral agent for the control of fleas and ticks on companion animals.
Peter T Meinke, Steven L Colletti, Michael H Fisher, Matthew J Wyvratt, Thomas L Shih

J Med Chem· June 2009

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Synthesis and biological activity of anticoccidial agents: 2,3-diarylindoles.
Andrew Scribner, Joseph A Moore, Gilles Ouvry, Michael Fisher, Matthew Wyvratt

Bioorg Med Chem Lett· March 2009

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Synthesis and biological activity of anticoccidial agents: 5,6-diarylimidazo[2,1-b][1,3]thiazoles.
Andrew Scribner, Susan Meitz, Michael Fisher, Matthew Wyvratt, Penny Leavitt

Bioorg Med Chem Lett· October 2008

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Synthesis and biological activity of imidazopyridine anticoccidial agents: Part II.
Andrew Scribner, Richard Dennis, Shuliang Lee, Gilles Ouvry, David Perrey, Matthew Wyvratt

Eur J Med Chem· June 2008

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Synthesis and SAR of potent and orally bioavailable tert-butylpyrrolidine archetype derived melanocortin subtype-4 receptor modulators.
Liangqin Guo, Zhixiong Ye, Feroze Ujjainwalla, Heather L Sings, Iyassu K Sebhat, Matthew J Wyvratt

Bioorg Med Chem Lett· June 2008

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N-alkyl-4-piperidinyl-2,3-diarylpyrrole derivatives with heterocyclic substitutions as potent and broad spectrum anticoccidial agents.
Gui-Bai Liang, Xiaoxia Qian, Dennis Feng, Michael Fisher, Tami Crumley, Matthew Wyvratt

Bioorg Med Chem Lett· March 2008

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3-Amino-1,5-benzodiazepinones: potent, state-dependent sodium channel blockers with anti-epileptic activity.
Scott B Hoyt, Clare London, Matthew J Wyvratt, Michael H Fisher, Doreen E Cashen

Bioorg Med Chem Lett· March 2008

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Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines.
Dooseop Kim, Jennifer E Kowalchick, Linda L Brockunier, Emma R Parmee, George J Eiermann, Matthew J Wyvratt

J Med Chem· February 2008

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Discovery of a novel class of benzazepinone Na(v)1.7 blockers: potential treatments for neuropathic pain.
Scott B Hoyt, Clare London, David Gorin, Matthew J Wyvratt, Michael H Fisher

Bioorg Med Chem Lett· August 2007

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Synthesis and SAR studies of potent imidazopyridine anticoccidial agents.
Gui-Bai Liang, Xiaoxia Qian, Dennis Feng, Michael Fisher, Christine M Brown, Matthew Wyvratt

Bioorg Med Chem Lett· July 2007

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