Publications by authors named "Jacintha Shenton"

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Accelerating adoption of new approach methodologies in regulatory decision making: an industry perspective.
Andrew S Robertson, Nahid Latif, Imein Bousnina, Donna Boyce, Kevin Carl, Jacintha Shenton

Nat Rev Drug Discov· June 2025

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Opportunities and insights from pharmaceutical companies on the current use of new approach methodologies in nonclinical safety assessment.
Jacintha Shenton, Imein Bousnina, Michael Oropallo, Rhiannon David, Lucinda Weir

Drug Discov Today· April 2025

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JNJ-78306358, a first-in-class bispecific T cell engaging antibody targeting CD3 and HLA-G.
Nataša Obermajer, Adam Zwolak, Kelly van de Ven, Shana Versmissen, Krista Menard, Jacintha Shenton

iScience· March 2025

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Current nonclinical approaches for immune assessments of immuno-oncology biotherapeutics.
Christine Grimaldi, Alex Ibraghimov, Andrea Kiessling, Benno Rattel, Changhua Ji, Jacintha Shenton

Drug Discov Today· February 2023

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FDA and industry collaboration: Identifying opportunities to further reduce reliance on nonhuman primates for nonclinical safety evaluations.
David Ackley, Joanne Birkebak, Jorg Blumel, Todd Bourcier, Christina de Zafra, Jacintha Shenton

Regul Toxicol Pharmacol· February 2023

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Comprehensive BCMA Expression Profiling in Adult Normal Human Brain Suggests a Low Risk of On-target Neurotoxicity in BCMA-targeting Multiple Myeloma Therapy.
Mathieu Marella, Xiang Yao, Vinicius Carreira, Marta F Bustamante, H Brent Clark, Jacintha Shenton

J Histochem Cytochem· April 2022

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Nonclinical safety assessment of engineered T cell therapies.
Herve Lebrec, Curtis C Maier, Kazushige Maki, Rafael Ponce, Jacintha Shenton

Regul Toxicol Pharmacol· December 2021

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Summary of a workshop on preclinical and translational safety assessment of CD3 bispecifics.
Cris Kamperschroer, Jacintha Shenton, Hervé Lebrec, John K Leighton, Paul A Moore

J Immunotoxicol· December 2020

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The T-cell-dependent antibody response assay in nonclinical studies of pharmaceuticals and chemicals: study design, data analysis, interpretation.
Hervé Lebrec, Brigitte Molinier, Darrell Boverhof, Mark Collinge, Wendy Freebern, Jacintha Shenton

Regul Toxicol Pharmacol· June 2014

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Monoclonal antibody therapeutics: history and future.
Nicholas A P S Buss, Simon J Henderson, Mary McFarlane, Jacintha M Shenton, Lolke de Haan

Curr Opin Pharmacol· October 2012

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Developmental immunotoxicity (DIT) testing of pharmaceuticals: current practices, state of the science, knowledge gaps, and recommendations.
Mark Collinge, Leigh Ann Burns-Naas, Gary J Chellman, Thomas T Kawabata, Wendy J Komocsar, Jacintha Shenton

J Immunotoxicol· September 2012

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Immunomodulatory effects of dietary potassium perfluorooctane sulfonate (PFOS) exposure in adult Sprague-Dawley rats.
David E Lefebvre, Ivan Curran, Cheryl Armstrong, Laurie Coady, Monique Parenteau, Jacintha Shenton

J Toxicol Environ Health A· October 2008

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Study of the sequence of events involved in nevirapine-induced skin rash in Brown Norway rats.
Marija Popovic, Jeff L Caswell, Baskar Mannargudi, Jacintha M Shenton, Jack P Uetrecht

Chem Res Toxicol· September 2006

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Evidence of an immune-mediated mechanism for an idiosyncratic nevirapine-induced reaction in the female Brown Norway rat.
Jacintha M Shenton, Marija Popovic, Jie Chen, Mary Jane Masson, Jack P Uetrecht

Chem Res Toxicol· December 2005

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Animal models of idiosyncratic drug reactions.
Jacintha M Shenton, Jie Chen, Jack P Uetrecht

Chem Biol Interact· November 2004

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Investigation of the involvement of macrophages and T cells in D-penicillamine-induced autoimmunity in the Brown Norway rat.
Mary Jane Masson, Munehiro Teranishi, Jacintha M Shenton, Jack P Uetrecht

J Immunotoxicol· April 2004

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Characterization of a potential animal model of an idiosyncratic drug reaction: nevirapine-induced skin rash in the rat.
Jacintha M Shenton, Munehiro Teranishi, Mones S Abu-Asab, Julie A Yager, Jack P Uetrecht

Chem Res Toxicol· September 2003

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