Publications by authors named "Mark Collinge"

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Application of Immunocompetent Microphysiological Systems in Drug Development: Current Perspective and Recommendations.
Xiaoting Wang, Anna K Kopec, Mark Collinge, Rhiannon David, Christian Grant

ALTEX· October 2025

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mRNA-LNPs induce immune activation and cytokine release in human whole blood assays across diverse health conditions.
Hong-My Nguyen, Kristin E Alexander, Mark Collinge, James C Hickey, Thomas A Lanz

Mol Ther· June 2025

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Relationship between lymphocyte count and risk of infection in Japanese rheumatoid arthritis patients treated with tofacitinib.
Yoshiya Tanaka, Tsutomu Takeuchi, Hernan Valdez, Mark Collinge, Samuel H Zwillich

Mod Rheumatol· October 2024

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Challenges and gaps in immunosafety evaluation of therapeutics: An IQ DruSafe survey.
Mark Collinge, Haley Neff-LaFord, Surekha Akella, Birgit Fogal, Kathryn Fraser

Regul Toxicol Pharmacol· June 2024

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Current approaches to evaluate the function of cytotoxic T-cells in non-human primates.
Cris Kamperschroer, Brendon Frank, Caroline Genell, Hervé Lebrec, Shermaine Mitchell-Ryan, Mark Collinge

J Immunotoxicol· December 2023

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A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6 T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation.
Wei Li, Kimberly K Crouse, Jennifer Alley, Richard K Frisbie, Susan C Fish, Mark Collinge

J Pharmacol Exp Ther· July 2023

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Microphysiological systems in early stage drug development: Perspectives on current applications and future impact.
Anna K Kopec, Ryuji Yokokawa, Nasir Khan, Ikuo Horii, James E Finley, Mark Collinge

J Toxicol Sci· September 2021

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Cross-company evaluation of the human lymphocyte activation assay.
Mark Collinge, Patricia Schneider, Dingzhou Li, Stanley Parish, Carolyne Dumont

J Immunotoxicol· December 2020

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T cell LFA-1-induced proinflammatory mRNA stabilization is mediated by the p38 pathway kinase MK2 in a process regulated by hnRNPs C, H1 and K.
Gautham K Rao, Albert Wong, Mark Collinge, Joseph Sarhan, Timur O Yarovinsky

PLoS One· January 2019

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Reversibility of peripheral blood leukocyte phenotypic and functional changes after exposure to and withdrawal from tofacitinib, a Janus kinase inhibitor, in healthy volunteers.
Kent J Weinhold, Jack F Bukowski, Todd V Brennan, Robert J Noveck, Janet S Staats, Mark Collinge

Clin Immunol· June 2018

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Immunologic effects of chronic administration of tofacitinib, a Janus kinase inhibitor, in cynomolgus monkeys and rats - Comparison of juvenile and adult responses.
Mark Collinge, Douglas J Ball, Christopher J Bowman, Andrea L Nilson, Zaher A Radi

Regul Toxicol Pharmacol· April 2018

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Evaluation of a novel delayed-type hypersensitivity assay to Candida albicans in adult and neonatal rats.
Mitchell Thorn, Adam W Hudson, John Kreeger, Thomas T Kawabe, Christopher J Bowman, Mark Collinge

J Immunotoxicol· May 2016

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Comparative nonclinical assessments of the proposed biosimilar PF-05280586 and rituximab (MabThera®).
Anne M Ryan, Sharon A Sokolowski, Chee-Keng Ng, Norimitsu Shirai, Mark Collinge

Toxicol Pathol· October 2014

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Validation of a Candida albicans delayed-type hypersensitivity (DTH) model in female juvenile rats for use in immunotoxicity assessments.
Mark Collinge, Mitchell Thorn, Vanessa Peachee, Kimber White

J Immunotoxicol· July 2014

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The T-cell-dependent antibody response assay in nonclinical studies of pharmaceuticals and chemicals: study design, data analysis, interpretation.
Hervé Lebrec, Brigitte Molinier, Darrell Boverhof, Mark Collinge, Wendy Freebern

Regul Toxicol Pharmacol· June 2014

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Challenges for inhaled drug discovery and development: Induced alveolar macrophage responses.
Ben Forbes, Raegan O'Lone, Philippa Pribul Allen, Anthony Cahn, Chris Clarke, Mark Collinge

Adv Drug Deliv Rev· May 2014

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Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis.
Lei Nie, Xiaojia Guo, Leila Esmailzadeh, Jiasheng Zhang, Abolfazl Asadi, Mark Collinge

J Clin Invest· December 2013

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Embryo-fetal transfer of bevacizumab (Avastin) in the rat over the course of gestation and the impact of neonatal Fc receptor (FcRn) binding.
Mitchell Thorn, Nicole Piche-Nicholas, Donald Stedman, Scott W Davenport, Ning Zhang, Mark Collinge

Birth Defects Res B Dev Reprod Toxicol· October 2012

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Developmental immunotoxicity (DIT) testing of pharmaceuticals: current practices, state of the science, knowledge gaps, and recommendations.
Mark Collinge, Leigh Ann Burns-Naas, Gary J Chellman, Thomas T Kawabata, Wendy J Komocsar

J Immunotoxicol· September 2012

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Macrophage β2 integrin-mediated, HuR-dependent stabilization of angiogenic factor-encoding mRNAs in inflammatory angiogenesis.
Jiange Zhang, Yasha Modi, Timur Yarovinsky, Jun Yu, Mark Collinge

Am J Pathol· April 2012

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Human lymphocyte activation assay: an in vitro method for predictive immunotoxicity testing.
Mark Collinge, Susan H Cole, Patricia A Schneider, Carol B Donovan, Cris Kamperschroer

J Immunotoxicol· June 2011

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Toxicopathology of the developing immune system: investigative and development strategies.
Daniel Weinstock, David B Lewis, George A Parker, Joseph Beyer, Mark Collinge

Toxicol Pathol· December 2010

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T cell LFA-1 engagement induces HuR-dependent cytokine mRNA stabilization through a Vav-1, Rac1/2, p38MAPK and MKK3 signaling cascade.
Vinod S Ramgolam, Scott D DeGregorio, Gautham K Rao, Mark Collinge, Sharmila S Subaran

PLoS One· December 2010

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Variant estrogen receptor-c-Src molecular interdependence and c-Src structural requirements for endothelial NO synthase activation.
Lei Li, Koji Hisamoto, Kyung Hee Kim, M Page Haynes, Philip M Bauer, Mark Collinge

Proc Natl Acad Sci U S A· October 2007

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LFA-1-dependent HuR nuclear export and cytokine mRNA stabilization in T cell activation.
Jin Gene Wang, Mark Collinge, Vinod Ramgolam, Oran Ayalon, Xinhao Cynthia Fan

J Immunol· February 2006

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