Publications by authors named "Jack D Scott"

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Discovery of sulfone containing metallo-β-lactamase inhibitors with reduced bacterial cell efflux and histamine release issues.
Frank Bennett, Yuhua Huang, Shuzhi Dong, Jinlong Jiang, David Hunter, Jack D Scott

Bioorg Med Chem Lett· December 2024

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Structure Guided Discovery of Novel Pan Metallo-β-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration.
Shuzhi Dong, Zhiqiang Zhao, Haiqun Tang, Guoqing Li, Jianping Pan, Scott R Pollack, Jack D Scott

J Med Chem· March 2024

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Synthesis of DNA-Encoded Macrocyclic Peptides via Nitrile-Aminothiol Click Reaction.
Lijun Fan, Yang Yu, Charles Jayne, John R Frost, Jack D Scott

Org Lett· November 2023

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Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease.
David A Candito, Vladimir Simov, Anmol Gulati, Solomon Kattar, Ryan W Chau, Jack D Scott

J Med Chem· December 2022

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Optimization of brain-penetrant picolinamide derived leucine-rich repeat kinase 2 (LRRK2) inhibitors.
Anmol Gulati, Charles S Yeung, Blair Lapointe, Solomon D Kattar, Hakan Gunaydin, Jack D Scott

RSC Med Chem· July 2021

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Development of DNA-compatible hydroxycarbonylation reactions using chloroform as a source of carbon monoxide.
Wentao Liu, Wei Huang, Qian Lin, Mei-Hsuan Tsai, Rui Zhang, Jack D Scott

Bioorg Med Chem· May 2021

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Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity.
Jack D Scott, Duane E DeMong, Thomas J Greshock, Kallol Basu, Xing Dai

J Med Chem· April 2017

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Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer's Disease.
Jack D Scott, Sarah W Li, Andrew P J Brunskill, Xia Chen, Kathleen Cox

J Med Chem· December 2016

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The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patients.
Matthew E Kennedy, Andrew W Stamford, Xia Chen, Kathleen Cox, Jared N Cumming, Jack D Scott

Sci Transl Med· November 2016

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MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition.
Matthew J Fell, Christian Mirescu, Kallol Basu, Boonlert Cheewatrakoolpong, Duane E DeMong, Jack D Scott

J Pharmacol Exp Ther· December 2015

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Characterization of a novel vasopressin V1b receptor antagonist, V1B-30N, in animal models of anxiety-like and depression-like behavior.
Robert A Hodgson, Deborra Mullins, Sherry X Lu, Mario Guzzi, Xiaoping Zhang, Jack D Scott

Eur J Pharmacol· May 2014

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Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor that Affords Robust CNS Aβ Reduction.
Andrew W Stamford, Jack D Scott, Sarah W Li, Suresh Babu, Dawit Tadesse

ACS Med Chem Lett· November 2012

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Diaryl piperidines as CB1 receptor antagonists.
Jack D Scott, Sarah W Li, Hongwu Wang, Yan Xia, Charles L Jayne

Bioorg Med Chem Lett· February 2010

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Tetrahydroquinoline sulfonamides as vasopressin 1b receptor antagonists.
Jack D Scott, Michael W Miller, Sarah W Li, Sue-Ing Lin, Henry A Vaccaro

Bioorg Med Chem Lett· November 2009

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Chemistry and biology of the tetrahydroisoquinoline antitumor antibiotics.
Jack D Scott, Robert M Williams

Chem Rev· May 2002

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Total synthesis of (-)-tetrazomine. Determination of the stereochemistry of tetrazomine and the synthesis and biological activity of tetrazomine analogues.
Jack D Scott, Robert M Williams

J Am Chem Soc· March 2002

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Total Synthesis of (-)-Tetrazomine and Determination of Its Stereochemistry.
Jack D Scott, Robert M Williams

Angew Chem Int Ed Engl· April 2001

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Total Synthesis of (-)-Tetrazomine and Determination of Its Stereochemistry This work was supported by the National Institutes of Health (Grant CA85419). We are grateful to Yamanouchi Pharmaceutical Co. for providing a generous gift of natural tetrazomine.
Jack D. Scott, Robert M. Williams

Angew Chem Int Ed Engl· April 2001

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