Publications by authors named "Jack Sadowsky"

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Effects of Pretargeting and FcRn Binding Abrogation on the Biodistribution of a One-Armed Antibody-Based T Cell Imaging Agent.
Danielle Mandikian, Lauren Sermeño, Rachana Ohri, Pragya Adhikari, Christopher W Davies, Jack D Sadowsky

Bioconjug Chem· August 2025

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On Demand Bioorthogonal Switching of an Antibody-Conjugated SPECT Probe to a Cytotoxic Payload: from Imaging to Therapy.
Pragya Adhikari, Guangmin Li, MaryAnn Go, Danielle Mandikian, Hanine Rafidi, Jack D Sadowsky

J Am Chem Soc· July 2024

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Site-Specific Dolasynthen Antibody-Drug Conjugates Exhibit Consistent Pharmacokinetic Profiles across a Wide Range of Drug-to-Antibody Ratios.
Susan M Clardy, Alex Uttard, Bingfan Du, Kalli C Catcott, Kelly L Lancaster, Jack Sadowsky

Mol Cancer Ther· January 2024

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The HER2-directed antibody-drug conjugate DHES0815A in advanced and/or metastatic breast cancer: preclinical characterization and phase 1 trial results.
Gail D Lewis, Guangmin Li, Jun Guo, Shang-Fan Yu, Carter T Fields, Jack Sadowsky

Nat Commun· January 2024

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LRRC15 myofibroblasts dictate the stromal setpoint to suppress tumour immunity.
Akshay T Krishnamurty, Justin A Shyer, Minh Thai, Vineela Gandham, Matthew B Buechler, Jack Sadowsky

Nature· November 2022

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A homogeneous high-DAR antibody-drug conjugate platform combining THIOMAB antibodies and XTEN polypeptides.
Neelie Zacharias, Vladimir N Podust, Kimberly K Kajihara, Douglas Leipold, Geoffrey Del Rosario, Jack Sadowsky

Chem Sci· March 2022

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Preclinical optimization of Ly6E-targeted ADCs for increased durability and efficacy of anti-tumor response.
Josefa Dela Cruz Chuh, MaryAnn Go, Yvonne Chen, Jun Guo, Hanine Rafidi, Jack Sadowsky

MAbs· October 2021

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Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties.
Peter S Dragovich, Thomas H Pillow, Robert A Blake, Jack D Sadowsky, Emel Adaligil

J Med Chem· March 2021

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Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy.
Peter S Dragovich, Thomas H Pillow, Robert A Blake, Jack D Sadowsky, Emel Adaligil

J Med Chem· March 2021

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Improved translation of stability for conjugated antibodies using an in vitro whole blood assay.
Aimee Fourie-O'Donohue, Phillip Y Chu, Josefa Dela Cruz Chuh, Robert Tchelepi, Siao Ping Tsai, Jack Sadowsky

MAbs· February 2021

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An Anti-CD22--CBI-Dimer Antibody-Drug Conjugate (ADC) for the Treatment of Non-Hodgkin Lymphoma That Provides a Longer Duration of Response than Auristatin-Based ADCs in Preclinical Models.
Shang-Fan Yu, Donna W Lee, Bing Zheng, Geoffrey Del Rosario, Douglas Leipold, Jack D Sadowsky

Mol Cancer Ther· February 2021

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Site-Specific Conjugation to Cys-Engineered THIOMAB™ Antibodies.
Pragya Adhikari, Neelie Zacharias, Rachana Ohri, Jack Sadowsky

Methods Mol Biol· January 2021

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Effect of Modulating FcRn Binding on Direct and Pretargeted Tumor Uptake of Full-length Antibodies.
Lidia Nazarova, Hanine Rafidi, Danielle Mandikian, Gregory Z Ferl, James T Koerber, Jack D Sadowsky

Mol Cancer Ther· April 2020

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Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα).
Peter S Dragovich, Pragya Adhikari, Robert A Blake, Nicole Blaquiere, Jinhua Chen, Jack D Sadowsky

Bioorg Med Chem Lett· February 2020

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Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity.
Thomas H Pillow, Pragya Adhikari, Robert A Blake, Jinhua Chen, Geoffrey Del Rosario, Jack D Sadowsky

ChemMedChem· January 2020

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Development of a Cysteine-Conjugatable Disulfide FRET Probe: Influence of Charge on Linker Cleavage and Payload Trafficking for an Anti-HER2 Antibody Conjugate.
Suzie J Scales, Siao Ping Tsai, Neelie Zacharias, Josefa Dela Cruz-Chuh, Gordy Bullen, Jack Sadowsky

Bioconjug Chem· December 2019

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Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody-Drug Conjugates.
Donglu Zhang, Aimee Fourie-O'Donohue, Peter S Dragovich, Thomas H Pillow, Jack D Sadowsky

Drug Metab Dispos· October 2019

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Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues.
Donglu Zhang, Peter S Dragovich, Shang-Fan Yu, Yong Ma, Thomas H Pillow, Jack D Sadowsky

Drug Metab Dispos· October 2019

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Site-specific conjugation allows modulation of click reaction stoichiometry for pretargeted SPECT imaging.
Danielle Mandikian, Hanine Rafidi, Pragya Adhikari, Priya Venkatraman, Lidia Nazarova, Jack Sadowsky

MAbs· June 2019

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An Anti-CLL-1 Antibody-Drug Conjugate for the Treatment of Acute Myeloid Leukemia.
Bing Zheng, Shang-Fan Yu, Geoffrey Del Rosario, Steven R Leong, Genee Y Lee, Jack Sadowsky

Clin Cancer Res· February 2019

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Development, Optimization, and Structural Characterization of an Efficient Peptide-Based Photoaffinity Cross-Linking Reaction for Generation of Homogeneous Conjugates from Wild-Type Antibodies.
Nicholas Vance, Neelie Zacharias, Mark Ultsch, Guangmin Li, Aimee Fourie, Jack Sadowsky

Bioconjug Chem· January 2019

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Modulating Antibody-Drug Conjugate Payload Metabolism by Conjugation Site and Linker Modification.
Dian Su, Katherine R Kozak, Jack Sadowsky, Shang-Fan Yu, Aimee Fourie-O'Donohue

Bioconjug Chem· April 2018

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Intratumoral Payload Concentration Correlates with the Activity of Antibody-Drug Conjugates.
Donglu Zhang, Shang-Fan Yu, S Cyrus Khojasteh, Yong Ma, Thomas H Pillow, Jack D Sadowsky

Mol Cancer Ther· March 2018

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Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody-Drug Conjugates with Phenol-Containing Payloads.
Donglu Zhang, Hoa Le, Josefa Dela Cruz-Chuh, Sudheer Bobba, Jun Guo, Jack D Sadowsky

Bioconjug Chem· February 2018

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Cathepsin B Is Dispensable for Cellular Processing of Cathepsin B-Cleavable Antibody-Drug Conjugates.
Niña G Caculitan, Josefa Dela Cruz Chuh, Yong Ma, Donglu Zhang, Katherine R Kozak, Jack Sadowsky

Cancer Res· December 2017

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